Nuclear translocation of spike mRNA and protein is a novel pathogenic feature of SARS

1Department of Biomedical Sciences, University of North Dakota School of Medicine & Health 6 Science ^ | 9/27/2022 | Sarah Sattar1#, Juraj Kabat2#, Kailey Jerome1 , Friederike Feldmann3 , Kristina Bailey4 , and 4 Masf

[RideForever]

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 causes severe pathophysiology in vulnerable older populations and appears to be highly pathogenic and more transmissible than SARS-CoV or MERS-CoV [1, 2]. The spike (S) protein appears to be a major pathogenic factor that contributes to the unique pathogenesis of SARS-CoV-2. Although the S protein is a surface transmembrane type 1 glycoprotein, it has been predicted to be translocated into the nucleus due to the novel nuclear localization signal (NLS) “PRRARSV”, which is absent from the S protein of other coronaviruses. Indeed, S proteins translocate into the nucleus in SARS-CoV-2-infected cells. To our surprise, S mRNAs also translocate into the nucleus. S mRNA colocalizes with S protein, aiding the nuclear translocation of S mRNA. While nuclear translocation of nucleoprotein (N) has been shown in many coronaviruses, the nuclear translocation of both S mRNA and S protein reveals a novel pathogenic feature of SARS-CoV-2.

Author Summary - One of the novel sequence insertions resides at the S1/S2 boundary of Spike (S) protein and 34 constitutes a functional nuclear localization signal (NLS) motif “PRRARSV”, which may supersede the importance of previously proposed polybasic furin cleavage site "RRAR". Indeed, S protein’s NLS-driven nuclear translocation and its possible role in S mRNA’s nuclear translocation reveal a novel pathogenic feature of SARS-CoV-2.

[RideForever]

This is too new to be peer-reviewed yet.

[Wuli]

“the nuclear translocation of both S mRNA and S protein reveals a novel pathogenic feature of SARS-CoV-2”

Fauxi approved “gain of function” research is a valid suspect for that.

[NonValueAdded]

they built it real good. Gain of Function is a crime against humanity.

[jimwatx]

There is a peer reviewed study back in February showing the spike protein can be reverse-transcribed and integrated into the genome of human cells.

https://www.mdpi.com/1467-3045/44/3/73/htm

Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues

https://www.pnas.org/doi/abs/10.1073/pnas.2105968118

So basically you would have to be insane to take this vax.

[thepoodlebites]

Josef Mengele would proud of Fauxi. Behold the new Angel of Death.

[ifinnegan]

You messed up the source, you put first author affiliation as source.

This is the link to use.

https://www.biorxiv.org/content/10.1101/2022.09.27.509633v1