Skip to comments.Nuclear translocation of spike mRNA and protein is a novel pathogenic feature of SARS
Posted on 10/02/2022 8:59:18 AM PDT by RideForever
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 causes severe pathophysiology in vulnerable older populations and appears to be highly pathogenic and more transmissible than SARS-CoV or MERS-CoV [1, 2]. The spike (S) protein appears to be a major pathogenic factor that contributes to the unique pathogenesis of SARS-CoV-2. Although the S protein is a surface transmembrane type 1 glycoprotein, it has been predicted to be translocated into the nucleus due to the novel nuclear localization signal (NLS) “PRRARSV”, which is absent from the S protein of other coronaviruses. Indeed, S proteins translocate into the nucleus in SARS-CoV-2-infected cells. To our surprise, S mRNAs also translocate into the nucleus. S mRNA colocalizes with S protein, aiding the nuclear translocation of S mRNA. While nuclear translocation of nucleoprotein (N) has been shown in many coronaviruses, the nuclear translocation of both S mRNA and S protein reveals a novel pathogenic feature of SARS-CoV-2.
Author Summary - One of the novel sequence insertions resides at the S1/S2 boundary of Spike (S) protein and 34 constitutes a functional nuclear localization signal (NLS) motif “PRRARSV”, which may supersede the importance of previously proposed polybasic furin cleavage site "RRAR". Indeed, S protein’s NLS-driven nuclear translocation and its possible role in S mRNA’s nuclear translocation reveal a novel pathogenic feature of SARS-CoV-2.
(Excerpt) Read more at biorxiv.org ...
“the nuclear translocation of both S mRNA and S protein reveals a novel pathogenic feature of SARS-CoV-2”
Fauxi approved “gain of function” research is a valid suspect for that.
they built it real good. Gain of Function is a crime against humanity.
There is a peer reviewed study back in February showing the spike protein can be reverse-transcribed and integrated into the genome of human cells.
Reverse-transcribed SARS-CoV-2 RNA can integrate into the genome of cultured human cells and can be expressed in patient-derived tissues
So basically you would have to be insane to take this vax.
Josef Mengele would proud of Fauxi. Behold the new Angel of Death.
You messed up the source, you put first author affiliation as source.
This is the link to use.
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