Posted on 09/22/2022 9:01:39 PM PDT by ConservativeMind
A team of scientists led by Duke-NUS Medical School have identified an important pathway that gets disrupted in the advanced form of non-alcoholic fatty liver disease known as non-alcoholic steatohepatitis (NASH)—and intervening with a naturally-occurring compound known as spermidine partially fixes the problem.
"Currently, there is no pharmacological therapy for NASH, with several drugs showing only limited efficacy in clinical trials, so there is an urgent need to better understand the molecular mechanisms that underlie it," said the study's first author Dr. Zhou Jin.
Dr. Zhou, senior author Professor Paul Michael Yen from the CVMD Program, and their colleagues in Singapore, the U.S., the U.K. and China first studied liver enzymes involved in a specific pathway in people who were healthy or had non-alcoholic fatty liver disease. They next carried their studies over to a preclinical model of NASH.
They found a molecular pathway that was disrupted by the condition. Put simply, NASH leads to the reduction of an enzyme, called deoxyhypusine hydroxylase, that is necessary for attaching the hypusine residue from spermidine to a critical protein involved in translating genetic code from RNA onto protein, called EIF5A.
Disruption of the pathway decreased the synthesis of proteins for the cell's energy powerhouse, called mitochondria. It also decreased mitochondrial activity and fatty acid metabolism.
The scientists next added a naturally-occurring compound called spermidine to the cell cultures and preclinical model. They observed increased fatty acid metabolism and improved mitochondrial function. There was also less liver inflammation and scar tissue formation associated with NASH.
"Our findings that the dysregulation of mitochondrial protein synthesis can be rescued by spermidine provides novel mechanistic insights, a therapeutic target, and potential prevention agent for managing non-alcoholic fatty liver disease," said Prof Yen.
(Excerpt) Read more at medicalxpress.com ...
Supplements are available, with Double Wood offering one.
How much wheat germ is GMO?
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Fatty liver and insulin resistance creates a vicious cycle.
I am going to try dragon fruit. It is expensive so I am opting for frozen at the moment to see if it helps glucose numbers . I saw an article at daily mail recommending it . Have also seen it for fatty liver
Some jokes just write themselves.
Thanks for posting. I wonder if real whole wheat foods (like bulghur) contain spermidine.
</chuckle>
}{€££ I did better with humor on the cable identification Post.
Don’t forget to tip your waitress...
“...cable identification Post...”
I must have missed that one.
Link?
Wonder if Kamala volunteered to be a test subject...
ICK...
I didn’t want breakfast today anyway but that’s just a conformation.
Wondering if anyone knows what this end of a computer cable fits ? (Vanity)
https://freerepublic.com/focus/f-chat/4095156/posts
Ha!
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