Posted on 09/21/2022 12:19:26 PM PDT by ConservativeMind
Scientists have shown that high-fat diets can cause rapid changes in the bone marrow of mice, driving the production of inflammatory immune cells.
The results may help explain how high-fat diets trigger inflammation, which can contribute to the development of insulin resistance, type 2 diabetes and other complications in individuals with obesity.
An invasion of inflammatory immune cells, called monocytes, into fat tissue is a hallmark of obesity. Many immune cells, including monocytes, are produced in the bone marrow, which is very sensitive to environmental changes. Scientists have already shown that fat cells in the bone marrow rapidly expand in response to a high-fat diet.
Klip and colleagues found that mice fed a high-fat diet begin to experience metabolic disturbances throughout their body and in the bone marrow within three weeks. Fat cells in the bone marrow multiply and take on white fat cell characteristics. Metabolic changes in the monocytes at the bone marrow cells also occur—they use less oxygen to break down sugar into energy, and lactic acid builds up in the cells and surrounding fluid. The team also found that mitochondria, cellular factories that break down sugar into energy, break apart into fragments within the monocytes and become less efficient. This process of mitochondrial fragmentation is associated with insulin resistance.
"These results show that high-fat diets can cause remodeling in bone marrow fat cells that disrupt the normal balance of monocytes, and can subsequently lead to invasive Ly6Chigh monocytes spilling into the body," continues Klip.
The team further demonstrated that white fat tissue can spur these changes in experiments using cell samples from mice fed a high-fat diet. They also found that brown fat tissue, which is more abundant in leaner people, can cause a shift towards the non-invasive Ly6Clow monocytes.
(Excerpt) Read more at medicalxpress.com ...
I will say a hallmark of the white fat tissue issue is having a lot of carbs with fat, though.
The mice were normally fed from birth to nine weeks, followed by either a 10% fat or 60% fat diet. The 60% fat diet had 20% protein and 20% carbs. The major fat was lard, with a pretty minor portion as soybean oil.
It seems keto is the best way to go when having higher fat intake, in light of this study, but note it was only performed on mice.
Likely disingenuous, with agenda.
Is this report about “immune cells that are inflamed,” or is it about cells that are immune to inflammation?” I’m confused by the stated description.
20% carbs is a high carb diet for someone on keto. 20g of carbs for most folks is max, or sub 4% carb calories in a keto diet. After that, you are no longer in keto for most folks.
bkmk
Yeah...maybe it was the CARBS?
I agree.
More junk “science”.
There’s a lot of literature out there that seed and vegetable oils like soybean oil will wreck your cardiovascular system as much as sugar.
So I’m not so sure that we have an apples to apples comparison here.
The soybean oil was 9% of the fat and lard was 91% of it.
Lemme put you in a cage and force feed you 60% lard diet. Something might go wrong.
I’ll take just a bit more moderation with mine, please.
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