Stressed mitochondria help cells survive respiratory infections (Very low dose doxycycline causes “good” stress)

Medical Xpress / Ecole Polytechnique Federale de Lausanne / Journal of Clinical Investigation ^ | August 31, 2022

[ConservativeMind]

Many respiratory infections add significant stress to cells and organs, which can lead to acute respiratory distress syndrome (ARDS), which can cause death.

"Novel therapeutic strategies to address ARDS, instead of fighting the infectious agent, could elicit the tolerance of the host organism towards the inflammatory challenge by boosting its natural adaptive stress responses," says Professor Johan Auwerx.

Adrienne Mottis and her colleagues have shown that one such strategy can exploit a biological phenomenon known as "mitohormesis". Mitohormesis describes the fact that a mild stress to a cell's mitochondria can induce a series of responses that actually increase the cell's health and viability.

"A mild level of mitochondrial stress can therefore be beneficial overall for the cell since the positive effect of these stress responses can overcome the negative effect of the initial stressor," says Mottis.

Because mitochondria have evolved from bacteria, they are susceptible to antibiotics. Therefore, the researchers looked at various antibiotics that could stress mitochondria, and identified novel molecules in tetracyclines.

The researchers screened 52 tetracyclines and selected novel molecules, such as 9-tert-butyldoxycycline (9-TB), that are highly potent at triggering mitohormesis even when used at low doses, while having no antibiotic effect—that is, they do not disturb the host's microbiome.

"Most importantly, our study shows that the 9-TB-triggered mitochondrial responses activate the ATF4 signaling pathway, a well-described response to multiple cellular stressors, and also mobilizes signaling pathways of innate immunity, the so-called type I interferon response," adds Auwerx.

"9-TB improved the survival of mice subjected to a lethal influenza infection while it did not impact on the viral load. Resistant hosts fight infection by eliciting an immune response that reduces pathogen load, whereas tolerance refers to the mechanisms that limit the extent of organ dysfunction and tissue damage caused by infection, not necessarily impacting on pathogen load."

[ConservativeMind]

The actual study says both 9-tert-butyl doxycycline (9-TB) and standard doxycycline (Dox) did the same thing, but standard doxycycline can have an effect on bacteria that is sidestepped with the 9-TB form.

It doesn’t impact COVID or the flu, but it definitely impacts death from them, via ARDS.

[ConservativeMind]

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[mewzilla]

It had to be doxy...

[mewzilla]

For anyone wanting to geek out...

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

9-TB and doxy mentioned.

[EasySt]

Before more drugs, have a look at recharging mitochondria with light.

https://www.the-scientist.com/news-opinion/worms-live-longer-with-mitochondria-powered-by-light-preprint-70051

https://www.intechopen.com/chapters/72594

https://luxtherapy.com/mitochondria-atp-red-light-charging-the-powerhouse-of-the-cell/

~Easy

[Paperpusher]

Didn’t Trump say something about shining light inside blood vessels?

[Faith65]

Thanks.
bkmk

[EasySt]

"Didn’t Trump say something about shining light inside blood vessels?"

~~~~~~

He dared to talk about developments like this and how science is discovering the potential for certain carefully controled dosages of specific light wavelengths delivered internally, like for certain upper respiratory infections, or by precise appication to blood passed through such apparatus, are lately proving to be real "Science".

The Engines of cells, your Mitochondria can also be "recharged" by certain harmless wavelengths red and infrared light.

President Trump was right. (About everything.)

https://patents.google.com/patent/US20100168823A1/en

~Easy

[citizen]

The text recommends a low-dose doxycycline...like a low-dose aspirin, I am guessing.

[ptsal]

Bkmk

[ptsal]

Post 8-
Thanks for the info and link.