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Black cardamom bioactives effective against lung cancer cells
Medical Xpress / National University of Singapore / Journal of Ethnopharmacology ^ | August 1, 2022 | Pooja Makhija et al

Posted on 08/04/2022 8:12:38 AM PDT by ConservativeMind

The main challenges associated with existing lung cancer drugs are severe side effects and drug resistance. There is hence a constant need to explore new molecules for improving the survival rate and quality of life of lung cancer patients.

In Indian Ayurvedic medicine, black cardamom has been used in formulations to treat cancer and lung conditions. A team of researchers studied the scientific basis behind this traditional medicinal practice and provided evidence of the cytotoxic effect of black cardamom on lung cancer cells. The research highlighted the spice as a source of potent bioactives, such as cardamonin and alpinetin, which could be used in the treatment or prevention of lung cancer. The study is the first to report the association of black cardamom extract with oxidative stress induction in lung cancer cells, and compare the spice's effects on lung, breast and liver cancer cells.

Dichloromethane extract treated cells were found to be killed mainly by apoptotic pathway where the measure of live cells, dropped to less than an average of about 20 percent after 48 hours of contact with the black cardamom extracted using dichloromethane. Cell death was caused by apoptosis with cells displaying morphological changes, such as shape distortion and shrinkage, increased oxidative stress, and a failure in DNA damage repair.

After running the black cardamom extract though liquid chromatography mass spectrometry analysis, the researchers linked the presence of two well-researched bioactives, cardamonin and alpinetin, to the cytotoxic potential of black cardamom.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; lungcancer
Black cardamom is a more expensive form, but still available from stores and online.
1 posted on 08/04/2022 8:12:38 AM PDT by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

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2 posted on 08/04/2022 8:13:21 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

They spoke about extracting it and about a powdered form.

How is it taken? (I am hoping someone with a better understanding will understand that from having read the article.)


3 posted on 08/04/2022 8:22:08 AM PDT by Chicory
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To: ConservativeMind

Quite tasty. Great in baked goods and spice mixes. Grind it in your coffee grinder and don’t clean your grinder. Cardamom in coffee is a treat.


4 posted on 08/04/2022 8:26:38 AM PDT by ConservativeInPA (Scratch a leftist and you'll find a fascist )
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To: ConservativeMind

And it’s a great additive/ingredient for a proper Bloody Mary. So, drink up!


5 posted on 08/04/2022 8:39:36 AM PDT by Bloody Sam Roberts (Great minds drink alike...me and my baby havin' a hell of a night. - - BB King)
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To: Chicory

The most practical approach is to imply use black cardamom.

These two substances do not appear to be commonly available.


6 posted on 08/04/2022 9:38:21 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeInPA

I arrived on contract in Arabia feeling like something the cat left in the litter box. Feeling like death warmed over, I fell asleep in the line shack which Stateside was a serious offense for a contractor. One of the Arab pilots came in to make tea. Worried about sleeping I apologized, he said no problem. He asked if I was okay and when I told him about being sick he said here, chew on these, swallow the black seeds inside and spit out the husk. It was cardamom. He was right it settled my stomach a bit and we had cardamom tea. He said cardamom helps with many things but it is great for upset stomachs. We became friends and I was his PC for the next year. Been drinking cardamom tea and coffee ever since. Maybe scientists should have asked a Bedouin, they drink a strong tea made out of nothing but cardamom. They claimed it was good for you, guess they were right.


7 posted on 08/04/2022 10:02:11 AM PDT by OldGoatCPO (No Caitiff Choir of Angels will sing for me)
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To: ConservativeMind

Black cardamom is available on Amazon and online through numerous spice stores.


8 posted on 08/04/2022 10:06:47 AM PDT by OldGoatCPO (No Caitiff Choir of Angels will sing for me)
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To: ConservativeMind

Thanks! I just wasn’t too sure how it would get to the lungs... not being good at biology 😳


9 posted on 08/04/2022 4:12:36 PM PDT by Chicory
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To: ConservativeInPA

Great idea. Thanks!


10 posted on 08/13/2022 10:58:37 AM PDT by MarMema (No bugs for consumption)
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