GlyNAC improves multiple defects in aging to boost strength and cognition in older humans (Some defects “reversed to the levels found in young adults” - eGFR up 15%, IL-6 down 77%, TNFa down 40%, Fasting Insulin down 55%, etc.)

Medical Xpress / Baylor College of Medicine / Clinical and Translational Medicine ^ | March 29, 2021 | Premranjan Kumar et al

[ConservativeMind]

A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione—could improve many age-associated defects in older humans.

The results of this study show that older humans taking GlyNAC for 24 weeks saw improvements in many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, genomic toxicity, muscle strength, gait speed, exercise capacity and cognitive function. The benefits declined after stopping supplementation for 12 weeks. GlyNAC supplementation was well tolerated during the study period.

Animal studies conducted in the Sekhar lab have shown that restoring glutathione levels by providing GlyNAC reverses glutathione deficiency, reduces oxidative stress and fully restores mitochondrial function in aged mice.

"We worked with eight older adults 70 to 80 years of age, comparing them with gender-matched younger adults between 21 and 30 years old," Sekhar said. "We measured glutathione in red-blood cells, mitochondrial fuel-oxidation, plasma biomarkers of oxidative stress and oxidant damage, inflammation, endothelial function, glucose and insulin, gait-speed, muscle strength, exercise capacity, cognitive tests, gene-damage, glucose-production and muscle-protein breakdown rates and body composition. Before taking GlyNAC, all these measurements were abnormal in older adults when compared with those in younger people."

The older participants took GlyNAC for 24 weeks, and then stopped it for 12 weeks.

"We are very excited by the results," Sekhar said. "After taking GlyNAC for 24 weeks, all these defects in older adults improved and some reversed to the levels found in young adults." The researchers also determined that older adults tolerated GlyNAC well for 24 weeks. The benefits, however, declined after stopping GlyNAC supplementation for 12 weeks.

[ConservativeMind]

I wanted to tell everyone here that Nestle’s GlyNAC capsules are sold as a serving with 600 mg of glycine and 600 mg of NAC, but that they want you to take that twice a day, meaning 1,200 mg of glycine and 1,200 mg of NAC a day.

They have a drinkable formula that is already 1,200 mg of each in a packet.

Of course, you can double your own combination of these ingredients, as you see fit, more inexpensively.

[MarMema]

Thanks. Seems like when I take these in the morning I sweat more, talk more, and feel jittery.
I wonder if it could be potentiating my thyroid...ever heard of anything like that?

[ConservativeMind]

Did you buy the Nestle Celltrient form or are you merging from two other sources? If the latter, what did you get and how much are you taking?