Cutting calories and eating at the right time of day leads to longer life in mice (35% longer life if only eating reduced calorie diet during most active part of the day)

Medical Xpress / Howard Hughes Medical Institute / Science ^ | May 5, 2022 | Victoria Acosta-Rodríguez et al

[ConservativeMind]

One recipe for longevity is simple to follow: eat less. Studies in a variety of animals have shown that restricting calories can lead to a longer, healthier life.

Now, new research suggests that the body's daily rhythms play a big part in this longevity effect. Eating only during their most active time of day substantially extended the lifespan of mice on a reduced-calorie diet, Joseph Takahashi and colleagues report.

In his team's study of hundreds of mice over four years, a reduced-calorie diet alone extended the animals' lives by 10 percent. But feeding mice the diet only at nighttime, when mice are most active, extended life by 35 percent. That combo—a reduced-calorie diet plus a nighttime eating schedule—tacked on an extra nine months to the animals' typical two-year median lifespan. For people, an analogous plan would restrict eating to daytime hours.

Scientists are just beginning to understand how calorie restriction slows aging at the cellular and genetic level. As an animal ages, genes linked to inflammation tend to become more active, while genes that help regulate metabolism become less active. Takahashi's new study found that calorie restriction, especially when timed to the mice's active period at night, helped offset these genetic changes as mice aged.

…Some of the mice could eat as much as they wanted, while others had their calories restricted by 30 to 40 percent. And those on calorie-restricted diets ate on different schedules. Mice fed the low-calorie diet at night, over either a two-hour or 12-hour period, lived the longest, the team discovered.

The results suggest that time-restricted eating has positive effects on the body, even if it doesn't promote weight loss. Takahashi points out that his study likewise found no differences in body weight among mice on different eating schedules—"however, we found profound differences in lifespan."

[ConservativeMind]

A reduced calorie, intermittent diet approach will increase your lifespan by 10% - 35%, depending on how you time it.

[ConservativeMind]

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[Wilderness Conservative]

Longevity doesnt have the appeal it is to have.

[Born in 1950]

Been doing intermittent fasting for years and I like it. Daily weights and vitamins for over 50 years. Highly recommend.

My advice is don't waste your time and effort unless you intend to keep it up forever. Being in shape five years ago does you no good.

Lol @ my advice, who the heck cares about my advice. Lol!!

[HenpeckedCon]

Tacked on nine months to a two year lifespan? Does that mean if I put the fork away I’ll like to 150?

[HenpeckedCon]

Tacked on nine months to a two year lifespan? Does that mean if I put the fork away I’ll make it to 150?

[Olog-hai]

Just what I always wanted: longer-lived mice.

[Robert DeLong]

Why should I cut calories and eat at the right time of day to length the lives of mice? 😋

Just joking.

[whitney69]

“A reduced calorie intake is not a workable product for diabetics or heart patients to use. Many times the recipients of diabetes when of advanced age can also add other problems inconsistent with a low calorie diet. The fad for keto and other starvation diets are not a sellable product for damaged bodies that can’t exercise to try to stay up with the fluctuation of weight, fitness, and stress caused by many of the more prevalent illnesses in today’s medical circumstances.

For instance, a diabetic either through stress, lack of sleep, common illnesses or even what you ate for dinner last night can cause huge differences in the preferred numbers the patient and their doctor are looking for. So this treatment like too many sells itself as a catchall and it won’t work for different people. And of course too high, hyper, or too low, hypo, can be dangerous and can cause death to many diabetic patients. Moderation is the tool used. But radical changes can be treacherous.

wy69

[sanjuanbob]

I care.

[moovova]

What the heck does me cutting calories and eating at the right time of day have to do with extending a mouse’s life?

[mass55th]

I always follow health care advice that is developed via testing on mice.

[allwrong57]

I actually prefer mice to have a shorter lifespan.

[ProtectOurFreedom]

“...no differences in body weight among mice on different eating schedules...but profound differences in lifespan.”

Now that is surprising, especially in light of all the articles you posted about excess body weight.

[Born in 1950]

Thanks for the smile, sanjuanbob. Best to you!

[aMorePerfectUnion]

Strange since it is normal to eat dinner in Spain at 10pm… and they are long-lived

[blam]

Calorie restricting diets, for decades, have been known to extend life. It's about the telomeres...the longer the telomeres at the end of the chromosomes, the longer you live.

Children born from young parents have longer telomeres than do children born from older parents, male and female and live longer lives too.

Now, I've found a way to extend my telomeres without starving:

Metformin: Anti-Aging Diabetes Drug Can Extend Life To 120 Years, Experts Say

People with diabetes on average live eight years less than people without diabetes. People with diabetes who take Metformin live longer than the people who do not have diabetes.

I take 2,000mg of Metformon everyday.