Weight loss and lifestyle program cuts severity of sleep apnea (45% of participants off CPAP @8 week end, 62% @6 month point & 29% had complete remission)

Medical Xpress / Healthday / JAMA Network Open ^ | Apr. 28, 2022 | Almudena Carneiro-Barrera, Ph.D. et al

[ConservativeMind]

An interdisciplinary weight loss and lifestyle intervention is associated with clinically meaningful and sustainable improvements in obstructive sleep apnea (OSA) severity and health-related quality of life, according to a study published online April 22 in JAMA Network Open.

Almudena Carneiro-Barrera, Ph.D., from the University of Granada in Spain, and colleagues randomly assigned 89 men (aged 18 to 65 years) with moderate-to-severe OSA and body mass index ≥25 kg/m² who were receiving continuous positive airway pressure (CPAP) therapy to an eight-week interdisciplinary weight loss and lifestyle intervention plus usual care or usual care alone.

The researchers found that the intervention group had a greater decrease in the apnea-hypopnea index (AHI; 51 percent reduction; −21.2 events/hour) than the control group (change, 2.5 events/hour). The reduction in AHI at six months postintervention was 57 percent in the intervention group, with a mean between-group difference of −23.8 events/hour. At the end point, 18 of 40 participants in the intervention group no longer required CPAP therapy and six achieved complete OSA remission, while at six months, 21 of 34 participants no longer required CPAP therapy and 10 achieved complete remission. Greater improvements in body weight were seen in the intervention group versus control group (change, −7.1 kg versus −0.3 kg); greater improvements were also seen for change in fat mass (−2.9 kg versus 1.4 kg), cardiometabolic risk, and health-related quality of life.

"This approach may therefore be considered as a central strategy to address the substantial impact of this increasingly common sleep-disordered breathing condition," the authors write.

[ConservativeMind]

The therapy that worked in just eight weeks?

From the abstract:

“8-week weight loss and lifestyle intervention involving nutritional behavior change, aerobic exercise, sleep hygiene, and alcohol and tobacco cessation combined with usual care.”

Folks, you can completely reverse Obstructive Sleep Apnea, even to the point of total remission and perfect O2, as if you were young again, if you do such simple steps, even at 65 years of age, the oldest in this trial, but I would bet it helps those even higher in age.

[ConservativeMind]

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[sauropod]

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[refermech]

Amazing, live a healthy lifestyle and you’ll likely have fewer maladies!

[Owen]

Something amiss with this. This is only 14 pounds lost and BMI was 25, the top end of normal. Just barely overweight.

The magnitude of apnea events appears huge. These guys must have been at 40+ per hour to get 20some improvement in just 14 pounds.

I doubt it. They may have just started sleeping on their side, which by itself decreases events.

My impression is most elderly with sleep apnea are not facing 40 AHI events. More like 10 or 15 the top end of mild. Sub 5 is difficult.

So my problem is the weight loss is mild. 14 pounds in a 6 foot man is about 2 BMI levels. Hard to imagine those 14 were what was closing passages.

[cherry]

well I rarely drink and I don’t smoke so that’s the easy part.

[thinden]

Sleep apnea info. Circle back

[Faith65]

Thanks.
BKMK