Posted on 03/24/2022 2:50:05 PM PDT by ConservativeMind
A team reports that two drugs show promise in rejuvenating lung epithelial progenitor cells damaged by chronic obstructive pulmonary disease (COPD). In their study, the group identified certain proteins involved in epithelial generation for targeting with prostanoids and tested them under different scenarios.
COPD is a disease of the lungs that develops when the immune system overreacts to conditions, such as smoke inhalation, and damages epithelial progenitor cells in the lungs. The job of epithelial progenitor cells is to produce new cells lining the lungs to keep them healthy. In their absence, patients experience shortness of breath and excess mucus production. Therapies have been developed to reduce the symptoms of COPD, but there is no cure. In this new effort, the researchers have identified two drugs that show promise in rejuvenating lung epithelial progenitor cells.
The work involved obtaining and analyzing data from prior studies using human and mouse lung tissue damaged by COPD due to smoking. In comparing the data with similar data from healthy patients, the researchers were able to isolate genes that became less active due to damage, which resulted in less production of two proteins. They then conducted a search of existing drugs that might be used to restore normal levels of the two proteins. They found two: iloprost, which has been used to treat high blood pressure in arteries in the lungs, and mioprostol, which has been used to treat stomach ulcers.
Testing of the drugs in mice showed them both able to restore the regenerative capacity of the progenitor cells. The researchers suggest this is because they worked to restart the circadian clocks in the cells that had been disrupted by long-term exposure to smoke. More work is required to find out if the regenerated cells actually result in new cells lining the lungs.
(Excerpt) Read more at medicalxpress.com ...
I didn’t state that it was used on its own for abortion.
I just wrote that it is used to induce labor, and in abortion.
I was speaking to the various uses of the drug, I wasn’t making a political statement.
The change in my neuropathy was almost instant. Within three days I was able to use only a cream to bring the pain into the tolerable range.
I reported the change to my doctor, she didn’t bother trying anything else on me.
I’m taking the albuterol sulfate 0.083% twice daily. It seems to help.
I’m not too keen on some of the side effects listed for the other drugs. BUT, if I have to take my chances or die sooner I guess I’ll take my chances.
“So not near as severe as the covid vaxxes”
Yeah, the “sudden and unexpected death” part of the covid vax is a real butt kicker.
“I see no sanity in believing death is preferred over possible side effects, especially on something easily trialed for very little money and effort.”
There is where you get into the Quality of Life discussion with your doctors. I’ve known a few people who chose to die rather than endure more pain.
One, a 16 year old boy, had been fighting cancer since he was 10, over half of his life. He finally told his parents he wasn’t undergoing any more chemo. He was just beaten down by the pain and knowledge that he would have to endure the pain and effects of chemo every day of his life. An extreme case, but he made his choice based on the quality of life he could expect.
I, for better off worse have had a preview of my end. My wife passed away in 2016 from Interstitial Lung Disease. I don’t cherish the knowledge that I will slowly suffocate over a period of years.
Depending on the side effects and how the medication does in my particular case I may or may not use it.
What good is life if you’re miserable, in pain or can’t enjoy life?
I’m in my late 60’s. I’ve lived my life and quite frankly it sucks without my angel.
I’ll just take it day by day.
Same for me.
It’s an “emergency inhaler” mist, and works great 3-5x/day.
(I also take 37 Rx & OTC pills each day, for 7 co-morbidities; 21 in the morning, and 16 in the evening.)
Thanks.
BKMK
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