Widely used nausea drugs linked to heightened risk of stroke (Up to 362% increase with antidopaminergic antiemetics)

Medical Xpress / British Medical Journal ^ | Mar. 23, 2022 | Stéphanie Debette et al

[ConservativeMind]

Drugs known as antidopaminergic antiemetics (ADAs) that are widely used to relieve nausea and vomiting caused, for instance, by migraine, chemotherapy or radiotherapy, and after surgery are associated with an increased risk of ischaemic stroke, finds a study published by The BMJ today.

The results show that all three ADAs studied (domperidone, metopimazine, and metoclopramide) were associated with an increased risk, especially in the first days of use, but the highest increase was found for metopimazine and metoclopramide. The researchers suggest that the potential action of ADAs on blood flow to the brain could explain this higher risk.

Like antipsychotics, ADAs are antidopaminergic drugs—they work by blocking dopamine activity in the brain. Antipsychotics have been associated with an increased risk of ischaemic stroke, but whether this risk could extend to other antidopaminergics including ADAs is not known.

They identified 2,612 patients from the nationwide French reimbursement healthcare system database (SNDS) with a first ischaemic stroke between 2012 and 2016 and at least one reimbursement for domperidone, metopimazine or metoclopramide in the 70 days before their stroke.

After taking account of potentially influential factors, the researchers found that new users of ADA could be at a 3-fold increased risk of stroke shortly after treatment started.

Further analyses by age, sex, and history of dementia showed similar results, with men at highest (a 3.59-fold increased) risk.

The risk appeared to increase for all ADAs, the highest increase being found for metopimazine (a 3.62-fold increase) and metoclopramide (a 3.53-fold increase), both of which are drugs that cross the blood-brain barrier.

And although further causal inference research is needed to confirm this association in other settings, they suggest that "the higher risk found for drugs crossing the blood-brain barrier suggests a potential central effect, possibly through an action on cerebral blood flow."

[ConservativeMind]

Consider lowering doses of these drugs, or falling back to a different type of drug, to evade the stroke risk.

[ConservativeMind]

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[iontheball]

They’ve got to blame the vax strokes/deaths on anything but the jab.

[aMorePerfectUnion]

Come, come, come…

This drug is FDA approved and passed scientific study!

This is modern “science-based medicine.”

[farming pharmer]

Consider lowering doses of these drugs, or falling back to a different type of drug, to evade the stroke risk.

The dose makes the poison in many instances.

In my experience, Reglan (metoclopramide) use is way down compared to 10-15 years ago. Post op ondansetron (Zofran) is what's used these days.

[Tennessee Conservative]

I have two dogs that take metoclopramide on an as needed basis for acid reflux. It’s also been widely used for dogs for a long time due to its safety. I have changed those two over to a homemade diet in hopes of eliminating any meds. My Vet swears it’s extremely safe and I trust the Vet more than any human doctor.

[the OlLine Rebel]

Actually these are rather aged drugs.

But it proves the point again that FDA-approved drugs DO get pulled at later dates.

[the OlLine Rebel]

The “meto” is Reglan, used for gastroparesis (paralyzed stomach, i.e., slow lazy stomach, which can lead to vomiting). I tried it and within the week I had to go to the ER for pounding, racing heart, in the middle of the night! It did not fully subside for months.

[aMorePerfectUnion]

Actually these are rather aged drugs.

Kind of makes it even worse, that they were prescribed by doctors claiming to be "evidence-based doctors" and they were harming patients.

[vetvetdoug]

Ginger is readily available, has a long history of effectivity, and is cheap.

[the OlLine Rebel]

Indeed, but nothing is perfect. I’m willing to accept imperfection. But it happens, and we should know that, and not be in total thralldom to the FDA or NIH or CDC. “Science” changes as more experience accrues. Biology is the worst for it. So many variables and no good way to squeeze anything down to a nice formula.

[mdmathis6]

Reduced cerebral blood flow....yes metoclopromide or reglan does reduce blood pressure and anything that reduces BP can bring on TIA’s or ischemic strokes...Has been known for years. Then again BP meds do the same thing.

Medical Expose is also responsible for calling for the removal of aspirin for MI and clot prophylaxis.

It is a nutty regressive website with questionable motives....I think more in line with population control advocates!

[ConservativeMind]

Medical Xpress posts the best source of current study write ups, but it unfortunately has its share of crazy studies and added poop from “The Conversation,” which is a site that never produces studies—it’s a liberal echo chamber from which someone creates “articles.”

I wade through the crud to get the legit stuff from journals and university press releases.