Researchers discover intake of FDA-approved drug modulates disease progression in Alzheimer's disease model (Time-release niacin)

Medical Xpress / Indiana University School of Medicine / Science Translational Medicine ^ | Mar. 23, 2022 | Miguel Moutinho et al

[ConservativeMind]

This used a prescription time release form of niacin.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

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[Osage Orange]

https://www.youtube.com/watch?v=fyZQf0p73QM

Opened my mind..........

[packagingguy]

Was it Niaspan? Had a friend who used to be a rep for that drug.

Fenchol from basil leaves was recently identified as possibly helpful also.

[FrankRizzo890]

I predict another study soon talking about how toxic time-released niacin is. After all, this HAS to be a cheap drug, and as everyone knows, we can’t have THAT now can we?

[Norski]

. . . However, this was news . . .

” , ,3) There is a chemical found in quantity in the bodies of schizophrenic persons. It is an indole called adrenochrome.

Adrenochrome (which is oxidized adrenalin) has an almost LSD-like effect on the body. That might well explain their behavior.

Niacin serves to reduce the body’s production of this toxic material. . . .”

[CrazyCatChick]

The niacin flush is REAL, y’all.

[ConservativeMind]

I do appreciate the things you add to the threads, but if you could, try to edit down what you post in long free form.

I spend time editing down my threads to keep thing as easy to read as possible. Long inserts of apparent books with a tables of content is probably best for a thread of its own. A link and brief write up is much more digestible for readers.

[Pilgrim's Progress]

They should find something . . . after all, they have a 24/7 lab rat living in the White House that is fully insured.

[Norski]

Sorry. Apologise. Will take care so to do so in future. Thank you for posting these.

Was quite startled at the article’s mention of adrenochrome in schizophrenics.

If all the pizzagate/blood drinking horror rumours about celebrities are true, this would be a viable explanation for their bizarre behaviors.

[gleeaikin]

I agree this post by Norski was quite long, and I am not totally innocent of posting content. What I do with a really long comment of interest is print it for later study. Reading such a post I find easier than doing all the research and information mining included in such a long post. I suspect if someone is really interested they will read it. If not they will skip over it. I am unclear on whether the rest of the comment is from the link given at the beginning. If the rest of the comment pertained to several sources, then perhaps additional links could have been included and somewhat less writing included in the comment.

[Faith65]

bkmk

[TangoLimaSierra]

Niacin ping

[Pete from Shawnee Mission]

CM thank you for posting!

Would Benfoetemine work??

[Norski]

Dear Mods:

Please be so kind as to pull this post.

Need to re-post in a shorter format for better use, as per request. Thank you. Norski

[Norski]

Will be reposting in shorter format in future as per post #16.
We do what we can to promote and maintain cordial exchange of information and opinions. Thank you, Norski

[ConservativeMind]

I could find nothing that mapped mechanisms of benfotiamine to HCAR2.

However, this supplement appears somewhat close to the one used:

“ENDUR-ACIN Niacin - Vitamin B3 500mg Extended Release & Low-Flush”

The prescription one uses a specific, very slightly different, form of nicotinic acid that in not the standard nicotinic acid, but the general behavior is likely similar.

[Norski]

Of hopeful note to those having loved ones with Alzheimer’s:

“

ALZHEIMER’S DISEASE: NUTRITIONAL THERAPIES

by Andrew W. Saul

First, some very good news:

Niacin halts and reverses Alzheimer’s disease.
The human dose equivalent of 2,000 to 3,000 mg/day of vitamin B3 was given to mice with Alzheimer’s.
One of the researchers reported, “Cognitively, they were cured. They performed as if they’d never developed the disease.”
http://orthomolecular.org/resources/omns/v04n25.shtml

Also see:
Reversal of Alzheimer’s Disease and Optimization of Brain Health with Orthomolecular Medicine, by Benjamin I. Brown, ND. Journal of Orthomolecular Medicine 2019, 34:1. https://isom.ca/article/reversal-alzheimers-disease-optimization-brain-health-orthomolecular-medicine/

Vitamins Help Prevent Alzheimer’s Disease: News Media Ignores Supplement Benefits . . .Again. Orthomolecular Medicine News Service, December 20, 2013 http://orthomolecular.org/resources/omns/v09n30.shtml

Choline
AD patients have a deficiency of the neurotransmitter acetylcholine because they are deficient in the enzyme, choline acetyltransferase, needed to make it. This results in curtailed manufacture and presence of acetylcholine in the brain. But there is a way around this: increasing dietary choline raises blood and brain levels of acetylcholine. Choline is readily available in cheap, non-prescription lecithin.

A large quantity of choline (from lecithin) is necessary for clinical results. Lecithin is non-toxic. [Little, et al (1985) A double-blind, placebo controlled trial of high dose lecithin in Alzheimer’s disease. J Neurology, Neurosurgery and Psychiatry, 48: 736-742.]

[steve86]

The usual cautions about adding niacin if you are taking statins. An interaction can cause increased risk of rhabdomyolysis, but minimally with smaller niacin doses.