Using paracetamol for protecting kidneys in patients with severe malaria (Acetaminophen protects kidneys against damage from severe cases of ruptured red blood cells)

Medical Xpress / Clinical Infectious Diseases / Menzies School of Health Research ^ | Mar. 3, 2022 | Daniel J Cooper et al

[ConservativeMind]

Paracetamol is used in many illnesses for the relief of pain and fever, but a study just published in Clinical Infectious Diseases has shown that it may also help protect against kidney damage in patients with malaria.

The study led by former Menzies Ph.D. student Daniel Cooper with A/Professors Bridget Barber, Matthew Grigg, and Professor Nick Anstey, with partners in Malaysia, found that for patients with severe malaria caused by the malaria parasite Plasmodium knowlesi (the most common cause of malaria in Malaysia), taking paracetamol regularly for 3 days led to improvements in kidney function when tested one week later.

Dr. Daniel Cooper said the findings are important because they will help provide the best possible treatment to patients with severe malaria.

"Even minor kidney injury can have long-term effects, so anything we can do to minimize kidney injury from malaria will be beneficial for these patients' long-term outcomes," Dr. Cooper said.

In collaboration with international partners, the study involved 396 people with knowlesi malaria in Sabah, Malaysia.

A/Prof Bridget Barber said that in severe malaria, red blood cells can rupture, releasing hemoglobin which can have a toxic effect on kidneys, and it's now believed that paracetamol can help to protect against these toxic effects.

"These results are consistent with other studies conducted in patients with other forms of malaria, including in adults in Bangladesh, and in children in Africa. Importantly, these findings also suggest that paracetamol may help to protect the kidneys in other conditions that are also associated with rupture of red blood cells," A/Prof Barber said.

[ConservativeMind]

There are a lot of conditions in which red blood cells rupture, so this could be a good adjunct treatment until the issue subsides.

It only used “normal” doses.

[ConservativeMind]

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[sauropod]

Bkmk

[algore]

for people in the USA

Paracetamol, also known as acetaminophen is mostly refereed to as Tylenol.

I will not keep that crap in my house.

I do have some aspirin (and yes I know that the 1918 flu was exacerbated by aspirin overdose) but used properly I think it can a good thing

I think I have some Ibuprofen that came with my emergency triage med kit.

I would never take doses for more than a few days in a month.

[algore]

Tylenol, a first gen painkiller designed by man

Natural Painkiller designed by God

Synthetic stuff designed to make profit on pain