New drug combinations found for resistant cancers (Free open access tool lets people find more optimal combo cancer treatments)

Medical Xpress / Wellcome Trust Sanger Institute / Nature ^ | Feb. 25, 2022 | Jesse S. Boehm et al

[ConservativeMind]

Sanger researchers have created the world's largest novel resource using systematic drug testing and genetics analyses to show new potential drug combinations for breast, colon, and pancreatic cancer.

New analysis has highlighted multiple drug combinations that could be effective therapies for some types of hard-to-treat cancers.

The research tested combinations of cancer drugs that are already used to treat patients. Scientists then created the world's largest resource that shows possible effective combinations for further study.

The paper also linked biomarkers that could be used to identify patients that would benefit from the newly highlighted combinations to ensure that they are used in the most effective way.

This freely available resource starts to define how combinations of cancer drugs in specific molecular backgrounds work together, with the aims of avoiding resistance, minimizing toxic side effects, and finding new treatments for some of the hardest to treat cancers.

The researchers hope that other scientists can use this resource to aid the future clinical development of combination therapies.

There are hundreds of thousands of possible drug combinations and we don't know which ones will be effective.

To demonstrate that their analysis is effective in a real world application, the researchers verified a drug combination in mice using colon cancer cells with a specific double mutation. This combined a drug already used for colon cancer with another one that is in clinical development. The combination halted tumor growth in mice, showing the benefit of combining drugs that are in clinical development with existing chemotherapies.

Many drugs are safe but do not show clinical efficacy on their own. This analysis can help show how these drugs could be combined to have a greater efficacy and which group of patients would potentially benefit, accelerating the development of new therapies.

[ConservativeMind]

This resource covers many drugs for many cancers, most of which may not have been previously used together, but should have greater efficacy, once tried.

[ConservativeMind]

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[HollyB]

Here’s the page

https://gdsc-combinations.depmap.sanger.ac.uk/

[thinden]

Thanx a lot for digging this up for us

[Trillian]

ping

[Glinda Whatsit]

Bookmark

[ptsal]

double thanks for the link

ptsal

[ConservativeMind]

Thank you, HollyB, for the direct link.

[Laslo Fripp]

BFL

[HollyB]

You’re welcome.

[Irish Eyes]

Bookmark

[lurk]

The Israelis are the ones to watch in research advances.