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Diseased male livers undergo sex change (Men with fatty liver get sleep issues, which helps the body make estrogens to protect the liver)
Medical Xpress / University of Queensland / Proceedings of the National Academy of Sciences ^ | Feb. 22, 2022 | Dr. Frederic Gachon et al

Posted on 02/23/2022 8:47:27 AM PST by ConservativeMind

The livers of men diagnosed with hepatic diseases change sex as part of a potential self-protective mechanism, according to University of Queensland research.

Institute for Molecular Bioscience (IMB) lead researcher, associate professor Frederic Gachon said the surprise discovery was made during an investigation into why disruption of the body's circadian clock is associated with obesity, type 2 diabetes and liver diseases.

"When a high-fat diet was fed to mice that had their circadian clock gene turned off, we expected them to develop diabetes or non-alcoholic fatty liver disease (NAFLD) like the control mice, but they didn't," Dr. Gachon said.

"We also found that the liver of the obese male mice had been feminized probably due in part to the protective nature of the female sex hormone, estrogen."

Like reproductive organs, the liver is sexually dimorphic, which means there are significant differences between the metabolic function of male and female livers.

The team then went on to study human samples and got the same results.

"The more advanced the disease, the more feminization we saw in the liver tissue," Dr. Gachon said.

"It appears that the disruption of circadian rhythms might be protecting the liver by influencing the levels of hormones such as growth hormone, estrogen and testosterone."

The internal body clock controls many biological functions including sleep, hormone secretion, body temperature and metabolism.

NAFLD is far more prevalent in men and affects 25% of the adult population, while sleep disorders are known symptoms of the disease.

"This study suggests that the disruption of the circadian clock gives the body flexibility in metabolic pathways that can help to slow down disease progression," Dr. Gachon said.

"In light of these findings, we are investigating whether behavioral and hormonal interventions are possible treatments for liver disease."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
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Extra estrogen helps male livers survive.
1 posted on 02/23/2022 8:47:27 AM PST by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Please email or private message me if you want on or off of this list.

2 posted on 02/23/2022 8:47:48 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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They also become irrational and forget how to do math


3 posted on 02/23/2022 8:50:11 AM PST by dsrtsage ( Complexity is just simple lacking imagination)
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To: ConservativeMind

That explains the menstrual cramps I’ve been having lately.


4 posted on 02/23/2022 8:52:10 AM PST by dfwgator (Endut! Hoch Hech!)
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To: ConservativeMind

Interesting. Thanks for posting.


5 posted on 02/23/2022 8:52:43 AM PST by DannyTN
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To: ConservativeMind

Bkmk


6 posted on 02/23/2022 8:55:40 AM PST by sauropod (Whom the gods would destroy they first make mad. Life is risk, your highness.)
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To: ConservativeMind

Distorting the meaning of words.
NO, livers do not change sex. Sex is a characteristic of the entire organism.


7 posted on 02/23/2022 8:57:36 AM PST by I want the USA back (Government is to be feared much more than the chicom virus.)
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To: ConservativeMind

Or, one could eat healthy, exercise, and not be a drunk and be a superior male.


8 posted on 02/23/2022 8:57:56 AM PST by EEGator
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To: ConservativeMind

Explosive headline that is as false as it can be


9 posted on 02/23/2022 9:02:31 AM PST by Nifster (I’m see puppy dogs in the clouds)
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To: ConservativeMind

As long as I don’t become a blond . . . it’s all good.


10 posted on 02/23/2022 9:08:45 AM PST by Pilgrim's Progress (http://www.baptistbiblebelievers.com/BYTOPICS/tabid/335/Default.aspx D)
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To: ConservativeMind
Extra estrogen helps male livers survive.

And could possibly be a root cause of rampant ED? Who can say.

11 posted on 02/23/2022 9:25:28 AM PST by Bloody Sam Roberts (Imagine, if you will, a vaccine so safe you have to be threatened to take it. )
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To: I want the USA back

Thank you for this nugget of truth. Estrogen is present in males as much as testosterone is present in females. It’s not the existence but the predominance of one over the other in utero that drives sex characteristics, but that’s all they are: characteristics. Your gender is determined at conception, period.

That said, gynecomastia is a real, growing problem among men. We are pumping our boys full of foods replete with phytoestrogens that are changing their development from a young age. Girls are also seeing problems in the form of earlier menses, rapid breast development resulting in very large breasts which in turn cause developmental issues such as back problems and can also lead to long term issues such as breast and uterine cancers.


12 posted on 02/23/2022 9:28:50 AM PST by rarestia (“A nation which can prefer disgrace to danger is prepared for a master, and deserves one.” -Hamilton)
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To: rarestia

Correction: “Your gender is determined at conception, period.” should be “Your sex is determined at conception, period.” Words have a gender, humans have a sex.


13 posted on 02/23/2022 9:34:29 AM PST by curious7
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To: ConservativeMind

That doesn’t change their SEX


14 posted on 02/23/2022 9:39:42 AM PST by Skywise
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To: dsrtsage

Lol


15 posted on 02/23/2022 9:45:23 AM PST by dinodino ( )
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To: ConservativeMind
BS.

They do not have a "sex change".

The human body NATURALLY produces both estrogen and testosterone.

In different quantities naturally depending if you are a man or a women but your body naturally produces both and both are needed.

16 posted on 02/23/2022 9:49:36 AM PST by Harmless Teddy Bear (It is better to light a single flame thrower then curse the darkness. A bunch of them is better yet)
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To: ConservativeMind

The more advanced the disease, the more feminization we saw in the liver tissue,” Dr. Gachon said.

“It appears that the disruption of circadian rhythms might be protecting the liver by influencing the levels of hormones such as growth hormone, estrogen and testosterone.”

—-

This may be true to a certain extent.It’s a well known fact that the liver can heal itself, but only so far. If it’s too badly damaged, scar tissue forms, and scar tissue does not do anything. It doesn’t function, other than to get in the way of the normal function of living tissue, and THAT is Cirrhosis.
I don’t think any amount of estrogen is going to reverse scarring and reproduce healthy tissue in anybody’s liver.


17 posted on 02/23/2022 9:59:45 AM PST by telescope115 (Proud member of the ANTIFAuci movement. )
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To: ConservativeMind

so the female livers dint change at all then...


18 posted on 02/23/2022 10:27:18 AM PST by Chode (there is no fall back position, there's no rally point, there is no LZ... we're on our own. #FJB)
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To: ConservativeMind

Are we gonna have to listen to idiots announcing their hepatic pronouns now?


19 posted on 02/23/2022 11:08:31 AM PST by TangoLimaSierra (⭐⭐Public hangings will wake 'em up.⭐⭐)
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To: ConservativeMind
The liver matabolizes estrogen removing it from the body. If the liver is under-performing, estrogen levels will be high.

That is all.

20 posted on 02/23/2022 11:17:03 AM PST by disclaimer
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