Posted on 02/09/2022 11:32:32 AM PST by MeneMeneTekelUpharsin
The most widely used methods for transdermal administration of the drugs are hypodermic needles, topical creams, and transdermal patches. The effect of most of the therapeutic agents is limited due to the stratum corneum layer of the skin, which serves as a barrier for the molecules and thus only a few molecules are able to reach the site of action. A new form of delivery system called the microneedles helps to enhance the delivery of the drug through this route and overcoming the various problems associated with the conventional formulations. The primary principle involves disruption of the skin layer, thus creating micron size pathways that lead the drug directly to the epidermis or upper dermis region from where the drug can directly go into the systemic circulation without facing the barrier. This review describes the various potential and applications of the microneedles.
The various types of microneedles can be fabricated like solid, dissolving, hydrogel, coated and hollow microneedles. Fabrication method selected depends on the type and material of the microneedle. This system has increased its application to many fields like oligonucleotide delivery, vaccine delivery, insulin delivery, and even in cosmetics. In recent years, many microneedle products are coming into the market. Although a lot of research needs to be done to overcome the various challenges before the microneedles can successfully launch into the market.
(Excerpt) Read more at sciencedirect.com ...
I’m still waiting for my thorazine patch so I can tolerate network news programs.
this came up early on in Covid
one of the things to try was glutathione which is sold for skin whitening
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7076458/
Looking for knowledgeable commentary on this system. A company is developing this to treat headaches. Thought that was very interesting.
there is someone here who is in the medical profession as is his wife. I think the alias was something like PA Engineer.
He is the one that told me about these kind of micro needle patches..so worth using if you want to try that kind of thing.
How soon before they find tens of trillions of micro needles have polluted every square inch of Mother Earth and we have the biggest environmental calamity ever?
Not so fast. There is a company developing treatment for headaches with that technology and my wife has bad headaches. I don’t think the microneedles will be a problem. Can’t stick someone in the head with a hypodermic needle.
Recent research finding trillions of bits of micro plastic in every corner of the globe. It’s going into our food and water supply. Is it a health concern or hazard? Who knows, but it wasn’t there before.
I’m just saying beware of unintended consequences.
The headlong rush to EVs powered by wind and solar is fraught with many such unintended consequences that we are ignoring and will pay dearly for in the future. Problems range from the loss of our vistas to hazardous waste to soaring power prices making food unaffordable, to dependence on China. It won’t end well.
Also handy for storing data under the skin
https://news.mit.edu/2019/storing-vaccine-history-skin-1218
The research was funded by the Bill and Melinda Gates Foundation and the Koch Institute Support (core) Grant from the National Cancer Institute.
mine was 1966
Still have fond, fond memories (nightmares) of those lines and the ensuing pain.
“Still have fond, fond memories (nightmares) of those lines and the ensuing pain.”
Orlando opened in 1968. Standing in formation on the asphalt under the hot December sun, starving. Then single file through.
Blood streaming due to cuts from the injectors as we only slowed to get the shots.
Modern acupuncture?
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