When it comes to obesity, the problem isn't an excess of fat but its loss of function (Lack of blood and oxygen supply makes fat cells dysfunctional)

Medical Xpress / Cell Press / Cell ^ | Feb. 3, 2022 | Sakers et al.

[ConservativeMind]

Obesity is known to cause cardiometabolic diseases like hypertension and diabetes but attributing these diseases to merely an overabundance of fat is a simplification. On a basic level, fat acts as a receptacle to store energy, but upon a closer look it is an essential actor in vital bodily processes like the immune response, the regulation of insulin sensitivity, and maintenance of body temperature. In a review published in the journal Cell on February 3rd, researchers argue that the negative health effects of obesity stem not simply from an excess of fat but from the decline in its ability to respond to changes, or in other words, its plasticity.

The makeup and functioning of this tissue changes in response to weight fluctuations and aging. As fat declines in plasticity due to aging and obesity, it loses its ability to respond to bodily cues. In the current model of this phenomenon, the rapid growth of adipose tissue outpaces its blood supply, depriving the fat cells of oxygen and causing the accumulation of cells that no longer divide. This leads to insulin resistance, inflammation, and cell death accompanied by the uncontrolled spill of lipids from these cells.

"The central role of adipose tissue dysfunction in disease and the incredible plasticity of fat tissue supports the promise of modulating fat tissue phenotypes for therapeutic purposes," write the authors, led by Claudio J. Villanueva. "Many questions and opportunities for future discovery remain, which will yield new insights into adipose tissue biology and hopefully lead to improved therapies for human disease."

[ConservativeMind]

We can literally outgrow our own ability to produce useful fat cells. In doing so, the cells behave in toxic ways, inflamed and causing inflammation issues throughout our body that create all sorts of problems seen in poor health.

[ConservativeMind]

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[fruser1]

And the solution is not eating less, but crapping more.

[Macoozie]

“an overabundance of fat is a simplification”

That’s just dumb.

If you weren’t FAT, you wouldn’t have the issues, now would ya?

I get it.
It’s nuance and Science and HopeyChangey and all that.

[Sergio]

bkmk

[antidemoncrat]

I’ve heard of dysfunctional brain cells but never dysfunctional fat cells.

[libh8er]

Saw this morning..

Overweight mother, 46, who was on the brink of type 2 diabetes at more than 105kg enters her first bodybuilding competition after shedding half her body weight

[stormhill]

Can they fund gain of function research for fat cells?
Dr. Fauci should look into it

[grey_whiskers]

Not Guilty!^TM

[wally_bert]

I’m impressed.

[wally_bert]

I’m bookmarking that story as it can be inspiring.

Today me, my wife and the physical therapy guy took a walk down the block and back. It’s the first time I went beyond the mailbox.

Zero problems and it was a pleasant morning.

For a few minutes, it felt like I was in a new world. I’ve only been home going on two weeks after a medical misadventure.