Posted on 01/20/2022 8:43:37 AM PST by ConservativeMind
A research team discovered that orally administrated bismuth drug colloidal bismuth subcitrate (CBS) together with N-acetyl cysteine (NAC) could be a broad-spectrum anti-coronavirus cocktail therapy.
Oral administration of the cocktail suppresses the replication cycle of the virus, reduces viral loads in the lung and ameliorates virus-induced pneumonia in a hamster infection model. Not only could NAC stabilize bismuth-containing metallodrugs at stomach-like conditions but also enhance the uptake of bismuth drugs in tissues (e.g. lung) and antiviral potency through oral administration. Bismuth subsequently suppressed virus replication of a panel of clinically relevant coronaviruses, including Middle East respiratory syndrome-related coronavirus (MERS-CoV), Human coronavirus 229E (hCoV-229E) and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its alpha variant (B.1.1.7) by inactivating multiple essential viral enzymes.
RBC, as well as other related bismuth drug(s), e.g., colloidal bismuth subcitrate (CBS) and bismuth salicylate (BSS), acts to precipitate in gastric juice and form a protective coating on the gastric wall, which leads to a hindered absorption in gastrointestinal tract. The findings revealed that NAC could prevent the hydrolysis of CBS in simulated gastric juice buffer (pH 1.2) and sodium bicarbonate buffer (pH 9.2), which form a highly stable and water-soluble Bi(III) thiolate complex, [Bi(NAC)3]. The combined use of NAC could significantly enhance the permeability of bismuth in parallel artificial membrane model, the human intestinal epithelial cancer cell line (Caco-2) model, and a modified ex vivo everted rat gut sac model. The in vivo pharmacokinetics data also consistently demonstrate that compared with the administration of CBS in the absence of NAC, the co-administration of CBS with NAC led to a remarkably improved bismuth uptake profile in both blood and lung tissues.
The therapeutic dosage of drugs induced only reversible nephrotoxicity and no systematic toxicities.
(Excerpt) Read more at medicalxpress.com ...
Not that I could find.
I know some people who will take glycine but substitute alpha-lipoic-acid for NAC. I did take ALA until recently. I saw a youtube in which it was stated that ALA is good for diabetics but not so good for for people without diabetes.
You can’t find NAC on amazon because they recently took it off. Why? There were no clinical reasons for it. Rather, there was a regulatory rule change.
Amazon confirmed this week it’s in the process of removing from its website dietary supplements containing NAC (N-acetyl-L-cysteine). FDA last year asserted in warning letters that NAC couldn’t be lawfully marketed in dietary supplements because it was first studied as a drug in 1963.May 6, 2021
https://www.naturalproductsinsider.com/regulatory/amazon-confirms-plans-removing-nac-supplements
I’m not sure I understand your issues with NAC. Can you provide a bit more color?
Recoil's a beeyutch!
I am not sure what you are referring to when you suggest that I have “issues” with NAC.
I’ve posted more stories on the benefits of NAC than practically any other Freeper, so I’m curious.
yeah i couldn’t find it either- lots of med articles about it, but nothing i saw about over the counter-
I thought the statement below was negative on NAC. But judging by your follow up comment —the statement was postive on NAC.
“Other than using them in equal doses, a COVID document describing 600 mg a day for prevention of issues, the knowledge that as we age, we create a bigger deficit, and that antioxidants or other therapies that reduce or help generate glutathione can help offset the benefit of NAC, I don’t.
I do know NAC can interfere with processes other antioxidants perform.”
You can just do the NAC and see how much glycine your body makes (we make some each day), but taking the glycine at the same time assures it's all there with the NAC. You could get the Jarrow time release NAC, which we have, and that helps it get absorbed over a number of hours, which also helps it glom onto glycine as it's made. However, we are primarily using a powder form of both. NAC capsules and a very inexpensive glycine powder. I have glycine capsules waiting to be used, simply because it's more convenient in that form, but it's also over double the cost per mg.
If you come across a study claiming higher dosages, please be sure to ping me.
Also, some supplements conserve glutathione and others help encourage glutathione to be made through other processes, so these minimize how much glutathione generation we could require.
“I saw a youtube in which it was stated that ALA is good for diabetics but not so good for for people without diabetes.”
Can you elaborate on that? I take ALA also; at times am pre-diabetic.
What provoked me to this conversation was a youtube by Michael Lustgarden. He’s one of a dozen or so youtubes I follow on longevity. His work is very detailed. Please do review it. The test involved 6 grams —but I’m not sure that it was six grams each of glycine and NAC or 6 grams altogether. The studies he cites also seemed to show that 6 grams of gylcine and NAC will get you to normal levels of glutathione within a couple weeks. But lower doses of glycine and NAC will get you to youthful levels of glutathione if they’re takin over longer periods of time.
I found the study to be convincing but I’d like to hear your take.
https://www.youtube.com/watch?v=XaxY7LpuSFo
Here’s a pubmed article that makes similar points.
https://pubmed.ncbi.nlm.nih.gov/33783984/
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