[ckilmer]

I thought the statement below was negative on NAC. But judging by your follow up comment —the statement was postive on NAC.

“Other than using them in equal doses, a COVID document describing 600 mg a day for prevention of issues, the knowledge that as we age, we create a bigger deficit, and that antioxidants or other therapies that reduce or help generate glutathione can help offset the benefit of NAC, I don’t.
I do know NAC can interfere with processes other antioxidants perform.”

[ConservativeMind]

Honestly, I have no knowledge I've come across that speaks authoritatively to more than 600 mg/day under normal occasions. The GlyNAC of studies is simply the same amount of glycine as NAC, so that would mean 600 mg/day of glycine.

You can just do the NAC and see how much glycine your body makes (we make some each day), but taking the glycine at the same time assures it's all there with the NAC. You could get the Jarrow time release NAC, which we have, and that helps it get absorbed over a number of hours, which also helps it glom onto glycine as it's made. However, we are primarily using a powder form of both. NAC capsules and a very inexpensive glycine powder. I have glycine capsules waiting to be used, simply because it's more convenient in that form, but it's also over double the cost per mg.

If you come across a study claiming higher dosages, please be sure to ping me.

[ConservativeMind]

Also, some supplements conserve glutathione and others help encourage glutathione to be made through other processes, so these minimize how much glutathione generation we could require.