Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US

jamanetwork.com/journals ^ | December 28, 2021 | Jing Sun, MD, MPH, PhD1; Qulu Zheng, MS1; Vithal Madhira, MS2; et al

[ransomnote]

[H/T Dalberg-Acton ]

Key Points

Question  Is immune dysfunction associated with an increased risk for COVID-19 breakthrough infection after SARS-CoV-2 vaccination?

Findings  In this cohort study of 664 722 patients who received at least 1 dose of a SARS-CoV-2 vaccine, those with immune dysfunction, such as HIV infection, rheumatoid arthritis, and solid organ transplant, had a higher rate for COVID-19 breakthrough infection and worse outcomes after full or partial vaccination, compared with persons without immune dysfunction.

Meaning  The findings suggest that persons with immune dysfunction are at much higher risk for contracting a breakthrough infection and thus should use nonpharmaceutical interventions (eg, mask wearing) and alternative vaccination approaches (eg, additional dose or immunogenicity testing) even after full vaccination.

ransomnote: abstract and full article available (includes download) at link 

 

Association Between Immune Dysfunction and COVID-19 Breakthrough Infection After SARS-CoV-2 Vaccination in the US | HIV | JAMA Internal Medicine | JAMA Network

 

[ransomnote]

PING

[humblegunner]

Well HELL YEAH!

Who among us doesn’t know and trust Jing Sun, MD, MPH, PhD1; Qulu Zheng, MS1; Vithal Madhira, MS2;.

They are the very cornerstones of trustworthiness.

Collectively, they are the A-Team of American Solidity.
There’s no doubting them, household names each and every one.

Why, just the other day I told my wife that she needed to
shut right the hell up and trust Qulu Zheng. And the plan.

[Delta 21]

So the shot makes you more susceptible to getting the virus?

[CatHerd]

Actually, for once, we have a legit study posted here, from the peer-reviewed Journal of the American Medical Association. Findings are what one would expect: those with autoimmune diseases (such as HIV and rheumatoid arthritis) are more likely to get “breakthrough” cases because their immune systems do not mount as strong a reaction to the vaccines.

Nothing weird or scary.

[ptsal]

Ransomenote, what a blessing to have you bird-dogging this topic. Thanks.

[CatHerd]

No. Read the study posted and my #5.

I left this bit out: those with compromised immune systems are not only more likely to get “breakthrough” infections, they also get sicker when they get said “breakthrough cases” than those who do not have compromised immune systems.

[ETCM]

People with a breakthrough infection after full vaccination were more likely to be older and women. People with HIV infection (AIRR, 1.33; 95% CI, 1.18-1.49), rheumatoid arthritis (AIRR, 1.20; 95% CI, 1.09-1.32), and solid organ transplant (AIRR, 2.16; 95% CI, 1.96-2.38) had a higher rate of breakthrough infection.

Who could possibly have predicted that older and/or immune compromised people would be more susceptible to breakthrough infections? Paging Dr. Obvious.

[jacquej]

I thought autoimmune diseases like rheumatoid arthritis, lupus, Hashimoto’s, etc are because the immune system is overactive - targeting bodily systems, not underactive.

Am I misguided?

[Prole]

You are of your father, Satan, just as Jesus mentioned in John 8:44.

Receive the Holy Spirit before it’s too late.

[Republican Wildcat]

Who could possibly have predicted that older and/or immune compromised people would be more susceptible to breakthrough infections? Paging Dr. Obvious.

It is interesting how breakthrough infections can occur for a virus that doesn't exist. This same poster posts article saying the virus does not and never existed, then also posts articles like this. Also posts articles stating that the vaccine will suppress the immune system, then posts other articles saying it will make the immune system overactive.

[humblegunner]

You are of your father, Satan

And your dad was a geek in a sideshow.

[Prole]

Like I said, John 8:44 says it all about you.

Receive the Holy Spirit before it’s too late.

[Texas Fossil]

Part of the A-Team (5,000 doctors are involved)

Here are some who are noted:

Texas COVID-19 Summit: Dr. Peter McCullough ‘Vaccines, Treatment, and Covid-19’
https://rumble.com/vpnz0g-texas-covid-19-summit-dr.-peter-mccullough-vaccines-treatment-and-covid-19.html

Texas COVID-19 Summit: Dr. Ryan Cole ‘Vaccines, Treatment, and Covid-19’
https://rumble.com/vpnxqm-texas-covid-19-summit-dr.-ryan-cole-vaccines-treatment-and-covid-19.html

Texas COVID-19 Summit: Dr. Bryan Ardis ‘Vaccines, Treatment, and Covid-19’
https://rumble.com/vpnxw6-texas-covid-19-summit-dr.-bryan-ardis-vaccines-treatment-and-covid-19.html

Dr. David Martin: Who “They” Are: “The Names and Faces of the People Who Are Killing Humanity (this one is being heavily filtered)
https://rumble.com/vpot5p-dr.-david-martin-who-they-are-the-names-and-faces-of-the-people-who-are-kil.html

[ETCM]

It’s probably an indirect correlation, caused by the immunosuppressant drugs prescribed for arthritis rather than the arthritis itself. Same for the transplant recipients, as they are on even stronger immunosuppressants.

[humblegunner]

Like I said, John 8:44 says it all about you.

You don't know jack and you couldn't pick me out of a three-man line up.

Sit down and mind your own business.

[House Atreides]

Absolutely STUNNING news: PEOPLE WHO HAVE WEAK IMMUNE SYSTEMS ARE MORE SUSCEPTIBLE TO INFECTION than people with strong immune systems.

Who knew! Thank you for posting this REVELATION which nobody would have suspected.

[Texas Fossil]

Last night I watched this 3 hour interview with Doctor McCollough:

Dr. Peter A. McCullogh with Joe Rogan

https://odysee.com/@jackspirko:a/rogan-mccullough:6

It gets better the further you go listening to the interview.

[Prole]

Like I said, receive the Holy Spirit before it’s too late.

[humblegunner]

Well, I’m not interested enough to go and read any of that.

Are any of them folks believers in the magnetism or the AIDS or the little bionic sea monkeys?

Because if they are, then I can point out who the looneys are real quick.