Gallic acid and stretching decrease osteoarthritis markers in cartilage cells (Tea, blueberries, & walnuts are sources)

Medical Xpress / Washington State University / Experimental Cell Research ^ | Dec. 15, 2021 | Sara Zaske / Haneen A. Abusharkh et al

[ConservativeMind]

A healthy diet and a little exercise appear to be good for arthritis, even on the cellular level.

A team led by Washington State University researchers used gallic acid, an antioxidant found in green tea and other plants, and applied a stretching mechanism to human cartilage cells taken from arthritic knees that mimics the stretching that occurs when walking. The combination not only decreased arthritis inflammation markers in the cells but improved the production of desired proteins normally found in healthy cartilage.

The laboratory tests suggested gallic acid as the most effective antioxidant for neutralizing the free radicals in the osteoarthritic cartilage cells. The researchers then applied the gallic acid and added stretching, using a cytostretcher developed by the company Curi Bio Inc. They set stretching to 5%, a level that matches the stretch in human knees when walking.

The combination decreased inflammation markers known as matrix metalloproteinases. It increased the deposition of collagen and glycosaminoglycans, which are compounds that give connective tissue its integrity, tensile strength and resistance to compressive forces from body weight on the joints. The stretching and gallic acid also increased the expression of two other cartilage-specific proteins.

Osteoarthritis, the most common musculoskeletal disorder in the world, destroys cartilage in joints causing pain and limiting movement. As of yet there is no complete cure, and treatments range from prescribing pain killers to replacing the joint surgically with a synthetic one, but even the surgery does not allow the patient to return to a full range of motion.

[ConservativeMind]

Strawberries, black currants, avocados, apples, bananas, and mulberries are other gallic acid sources.

[ConservativeMind]

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[Bob434]

have you run across anything on mitochondrial dysfunction or chronic fatigue/fibromyalgia?

[ConservativeMind]

Definitely.

https://freerepublic.com/focus/search?m=all;o=time;q=quick;s=mitochondria

Additionally, mushrooms (especially oyster) have ergothioneine, which our cells need and have retained ion channels only for delivering that to our mitochondria. It is a long-lived antioxidant (nearly four weeks, once in the mitochondria) and it quenches free radical damage that bring a shorter life to them. A supplement called MitoQ does something similar, but only lives a day or two, is expensive, and can have drawbacks.

A supplement called “PQQ” spontaneously generates new mitochondria in cells.

There are other ways to help our cells’ energy producers, “mitochondria,” but this should be a start, and, it should be its own thread.

[Bob434]

Thanks, i will check into that- i have to be careful of things that can stimulate immune system though-

[[here are other ways to help our cells’ energy producers, “mitochondria,” but this should be a start, and, it should be its own thread.]]

Agreed- it’s an important topic=-

[Bob434]

as well as have to be careful with kidney problems

[nutmeg]

.