Posted on 12/08/2021 1:46:06 PM PST by ConservativeMind
A study in mice has found that stress and tissue damage initiated by angiotensin II, a molecule that is known to increase blood pressure and stiffening in the linings of blood vessels, leads to cellular senescence, a process by which a cell ages and permanently stops dividing but does not die. Importantly, when the researchers eliminated senescent cells from the mice, tissues returned to a normal state in spite of a continued infusion of angiotensin II.
We've known that angiotensin II can lead to hypertension and cellular damage, but our findings show that chronic, stress-induced damage due to slightly elevated blood pressure could be reduced by eliminating senescent cells," says Irfan Khan, an MD/Ph.D. candidate.
The researchers chose angiotensin II as the tool to best induce chronic stress because they could regulate its administration and induce a measured stress level similar to that seen in people who see a slow rise in blood pressure over a lifetime. The researchers discovered that these effects are particularly pronounced in the kidneys.
"We can give people angiotensin lowering drugs to treat their high blood pressure. But they have to be given for a lifetime. "Essentially, we're building the biological basis for a new therapeutic approach to address the senescence aspect of disease. Eliminating senescent cells with a tolerable, short-term therapy could potentially alleviate chronic cardiovascular disease and reduce the need for a lifetime of therapy."
The researchers hope to be able to reverse some premature tissue damage. "A senescence drug would probably be a very short-term treatment, maybe just a few days to two weeks," Wellstein says. "Rather than constantly trying to dampen down high blood pressure, we propose getting rid of the senescent cells so that a physician could more easily treat the primary causes."
(Excerpt) Read more at medicalxpress.com ...
Fisetin is in strawberries, but you need a pound of strawberries to equal the amount of fisetin in a standard supplement.
Natural Senolytics: Dasatinib And Quercetin, Circumen, Fisetin Senolytic, And More
https://the-unwinder.com/science/senolytics-supplements/
An interesting picture here of two mice, one having taken this substance:
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