Eucalyptus compound effective at treating lung damage in sheep model (Pinocembrin, also in propolis and honey, “striking” results)

Medical Xpress / PLOS ONE ^ | Dec. 3, 2021 | Habtamu B. Derseh et al

[ConservativeMind]

University of Melbourne-led research has shown the flavonoid pinocembrin, derived from Australian eucalyptus trees, has strong anti-inflammatory properties and could be safe and effective at treating lung fibrosis in sheep, a large animal model for human lung disease.

Pinocembrin, a flavonoid found in several different type of trees including pine trees and eucalyptus, has been reported to have antioxidant, anti-inflammatory, anti-microbial and anti-cancer properties.

Researchers from the University of Melbourne, Monash University, Swinburne University of Technology and industry partner Gretals Australia, set out to test the anti-inflammatory and anti-fibrosis properties of pinocembrin in 10 sheep, to see whether the compound could be effective at treating lung fibrosis.

In the study, the fibrosis was induced in two localized lung segments in each of the sheep. One of the segments was treated with 7mg of pinocembrin once weekly for four weeks, while the other segment was left untreated.

Co-lead author on the study, Dr. Habamu Derseh, from the Melbourne Veterinary School in the Faculty of Veterinary and Agricultural Sciences at the University of Melbourne said the results were "striking."

"We found that pinocembrin improved lung function, attenuated lung inflammation, and decreased overall pathology scores compared to damaged lungs that were untreated," Dr. Derseh said.

"We saw striking anti-inflammatory effects and modest anti-fibrotic remodeling after four weeks of administering pinocembrin."

Co-lead author Professor Ken Snibson, also from the Melbourne Veterinary School, explained there was a 50 percent reduction in certain inflammatory cells in the lungs.

"In lung fluid samples, inflammatory cells called neutrophils dropped from 7.4 percent of total cells to 3.7 percent in the pinocembrin-treated bleomycin-injured lung segments."

The chemical for this trial was isolated from the leaves of eucalyptus saplings at the University of Melbourne.

[ConservativeMind]

I could not find the pure extract, but other sources point to propolis and honey as having it as an accompanying compound.

[ConservativeMind]

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[Pajamajan]

Interesting.

[The Duke]

Ivermectin also has strong anti-inflammatory properties (do a search).

[matthew fuller]

Is there any of the substance in Eucalyptus oil?

[FreedomPoster]

When this all settles out, I am actually tempted to get on the same Ivermectin prophylaxis schedule as my dogs (monthly).

[The Duke]

I sent some Iver to I woman I know who had suffered with chronic pain for 30 years. She started taking a little every day as a preventative, and for the first time in all those years her pain subsided. So, she swears by it now.

As always, your mileage may vary. But I would say it’s worth trying.

[FreedomPoster]

That’s quite interesting. Daily would seem a bit of overkill for Covid prophylaxis, based on what I’m seeing. And I took some as well for that, during the two big spikes last Winter and this late Summer/early Fall.

My earlier comment was driven by an observation I saw that all mammals that humans commonly interact with are typically on a deworming schedule - but humans are not!

And with Ivermectin, it pretty much can’t hurt. The safety profile is at the level of aspirin, and substantially better than Tylenol.

Lots of good Ivermectin links:

https://freerepublic.com/focus/bloggers/4017132/posts?page=19#19