A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice

NIH PMC ^ | 04/28/2021 | David Martinez and others

[Grandpa Drudge]

Abstract

SARS-CoV in 2003, SARS-CoV-2 in 2019, and SARS-CoV-2 variants of concern (VOC) can cause deadly infections, underlining the importance of developing broadly effective countermeasures against Group 2B Sarbecoviruses, which could be key in the rapid prevention and mitigation of future zoonotic events. Here, we demonstrate the neutralization of SARS-CoV, bat CoVs WIV-1 and RsSHC014, and SARS-CoV-2 variants D614G, B.1.1.7, B.1.429, B1.351 by a receptor-binding domain (RBD)-specific antibody DH1047. Prophylactic and therapeutic treatment with DH1047 demonstrated protection against SARS-CoV, WIV-1, RsSHC014, and SARS-CoV-2 B1.351infection in mice. Binding and structural analysis showed high affinity binding of DH1047 to an epitope that is highly conserved among Sarbecoviruses. We conclude that DH1047 is a broadly neutralizing and protective antibody that can prevent infection and mitigate outbreaks caused by SARS-like strains and SARS-CoV-2 variants. Our results argue that the RBD conserved epitope bound by DH1047 is a rational target for pan Group 2B coronavirus vaccines.

[Grandpa Drudge]

Promising "Real Science" research into an actual solution against Covid-19.

I hope it's really real...

[null and void]

I hope it's really real...

Only because you aren't making money from the sales )and kickbacks) that go away when the EUA is voided by an effective treatment...

[null and void]

Only because you aren't making money from the sales (and kickbacks) that go away when the EUA is voided by a officially recognized effective treatment...

[PMAS]

**

[Pete from Shawnee Mission]

Oh yah, this is REAL science, you mean more like real MARKETING

https://freerepublic.com/focus/f-bloggers/4012177/posts

Isn’t it amazing that HCQ, Ivermectin, and Pfizer’s PAXLOVID ($72per pill) all inhibit the same SARS 3CLpro enzyme to inhibit replication? twitter ^ | Nov 11th, 2021 | Clarke MD

Posted on 11/12/2021, 11:09:51 AM by Mount Athos

Weird that two are “snake oil” and the expensive one will get EUA {Emergency Use Authorization by the FDA}

[null and void]

new tagline

[Grandpa Drudge]

Another version of this story:

Duke, UNC scientists identify new antibody for COVID-19 and variants

https://uncnews.unc.edu/2021/11/02/covid-19-antibody/#:~:text=A%20research%20collaboration%20between%20scientists,as%20the%20original%20SARS%20illness.