Posted on 11/01/2021 7:45:40 PM PDT by ConservativeMind
Chronic inflammatory bowel disease (IBD) are inflammations of the gastrointestinal tract which flare up in phases and are accompanied by bloody bowel movements, diarrhea and severe impairment of the quality of life. IBD patients exhibit an increased risk of developing colorectal cancer. This is facilitated by the fact that DNA in the intestinal mucosa cells (intestinal epithelium) is damaged by chronic inflammatory processes. Upon DNA damage, a cell in a healthy state protects itself from accumulation of a defective genome by not dividing further. However, these protective mechanisms are suspended under inflammatory conditions, which promotes the development of bowel cancer. It is not yet understood why these protective mechanisms become dysfunctional in the event of chronic inflammation.
Potential therapeutic approach
In medicine, the mTOR signaling pathway has long been used as a therapeutic target for other diseases, and could provide a new early access for cancer treatment. The researchers treated mice and cell systems that display increased DNA damage and a defective XBP1 gene with a specific inhibitor of the mTOR pathway, the pharmacological substance Rapamycin. "In our models, Rapamycin significantly reduced the increased cell division and the resulting damage to the intestinal epithelium," reported Aden.
"Although we have known for a long time that cancer can arise from chronic intestinal inflammation, we only know relatively little about the underlying processes. Our results now provide a new link between inflammation, disturbed cell division and repair of genetic material," reported senior author Professor Philip Rosenstiel.
(Excerpt) Read more at medicalxpress.com ...
So.when you all say no wheat, is it just the gluten or no wheat period? Does gluten free stuff get me to where I want to be? I swear gluten free stuff is becoming better tasting than the regular. First time in my life that something taste better than the unatural, synthetic, boxed, packaged, non fresh,processed food that my body has craved from the day I was born!
I have never had any sensitivity to gluten at all, but I appreciate what you're saying.
It has nothing to do with gluten sensitivity. The wheat grown today is nothing like the wheat grown 50 years ago which was nothing like the wheat grown 100 years before that. The agricultural industry (think: Monsanto) is modifying wheat regularly to produce a product that is disease resistant, insect resistant, drought tolerant, fast growing, and high yield, but each modification isn’t tested in a lab for how it impacts humans. It’s not even tested on animals. It’s just assumed to be okay because the product that comes out looks, smells, and tastes like wheat.
I highly recommend “Wheat Belly” by Dr. William Davis. It will likely shock you.
OK, fine. Thank you for riffing off my original snarky comment on this thread, but all well and good.
Look, I’m 60 years old, my stomach is made of iron. I eat anything that is offered me, to include cobra, crocodile, and ant eggs. My bowels work great, thanks.
If the street food here doesn’t kill me, eating a pizza every couple of weeks won’t either.
“Somehow I doubt this very much.”
I read the info in an article about bananas not that long ago, but of course I can’t find it now. It stuck in my head, because I thought it was pretty weird that there could be a difference. That’s why I mentioned it. I did another search, and found other articles that say there is no difference, other than unripened bananas have less sugar in them than ripened. I’m diabetic, and don’t think I mistook potassium levels for sugar levels when I read that article. I ended up in the hospital back in 2016 because my electrolytes were all screwed up. My potassium, magnesium, and sodium levels were very low. I was on a prescribed potassium pill at the time, but for some reason that level was very low. They never figured out what caused it. They took me off the potassium pill, because they said too much potassium can be as dangerous as too little.
Just rechecked and found that there is no difference between ripened and unripened bananas when it comes to potassium. I swear I read that there was, not very long ago, and wondered about it. There's less sugar in an unripened banana than a ripened one, but I don't believe I mistook sugar levels with potassium levels, because I'm diabetic, and I would have made a note of that when I read that original article. Can't find it now though. I posted this in another reply to someone else:
"I ended up in the hospital back in 2016 because my electrolytes were all screwed up. My potassium, magnesium, and sodium levels were very low. I was on a prescribed potassium pill at the time, but for some reason that level was very low. They never figured out what caused it. They took me off the potassium pill, because they said too much potassium can be as dangerous as too little."
If we drink water low in minerals, it can absorb minerals from the intestine.
If vitamin d is higher than normal, the intestine might receive a small amount of calcium and magnesium. That can cause a reduction of the potassium content of the intestine.
A reduction of potassium in the intestine will cause a reduction of potassium in the blood.
Thanks for your response and info.
I am not diabetic, but before I received my new(to me) liver, I occasionally would have a low blood sugar episode, as my old liver was too damaged to filter my blood properly. They told me it wasn’t unusual for that to happen with end stage liver disease. I would be at home, at work, or at the store and start getting hot, sweaty from head to foot, and rubber-legged. At least at the store I could hang onto the shopping cart until I could sit down and scarf down a candy bar or drink some orange juice. At work I went to the break room and did same. At home my wife, God Bless her, would run and get me something.
At first I thought “I should eat a better breakfast”, but after a while, it didn’t matter, a candy bar or a bottle of orange juice went to work with me every day,
just in case….
After my transplant, no more episodes.
I can’t take my transplant meds until AFTER having the blood draw, that would throw everything off.
As my body gets used to it’s new tenant, my meds have to get tweaked from time to time, and if any results are way off, it could mean rejection.
I retired a year ago last June. I wanted to work a couple more years, but the edema in my feet and legs made that impossible, since I was on my feet all day.
People like you and me have our histories- it sure makes our lives anything but boring!😎
Since I’ve been on oral diabetic medication, I’ve had to carry hard candy around with me, just in case. I had to stop eating Kellogg’s Corn Flakes, which I used to sweeten with Splenda, because the cereal spiked my blood sugar. I have to make sure I eat within a certain time after I’ve taken my morning pills, or I’ll end up with low sugar. I can usually tell when it’s coming on, and avoid it getting too bad. Good luck with your new liver. Has the edema at least gone away or diminished since you got the transplant? You’ve been through a lot, and I will keep you in my prayers.
Thanks for the info. My doctor prescribed Vitamin D once a week, but I don’t believe I was on it at the time of my hospitalization. At first they thought the electrolyte problem was caused by a bladder infection that my Urologist claimed I had, but when the hospital checked my urine, they found no infection. I’d had my gall bladder out the fall before (2015), so I’m not sure if that could have had anything to do with it. I also have an underactive thyroid, and an overactive parathyroid, which causes me to have high calcium levels.
Yes, the edema went away, with the help of water pills. The first day after surgery, my right arm and hand swelled up, which they have never done before. They were back to normal by the time I was discharged.
My labs came back, everything seems to look good.
I’m sorry you have to do so much monitoring of your health. It seems like a lot of work. I’ll keep you in my prayers, as well.
The good thing is, I won't have to do that after I'm dead 😁
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