Mutations in R.1 found in other variants. Those in red are unique to R.1. ACCESS HEALTH INTERNATIONAL
Posted on 09/23/2021 6:34:07 PM PDT by SeekAndFind
A new variant has been detected in a Kentucky nursing home, infecting 45 residents and health care personnel. Many of these infections arose in fully vaccinated individuals. The variant, which originated in Japan, has over 10,000 entries in the GISAID SARS-CoV-2 database. The variant contains five mutations previously noted in variants of concern or interest, two of which are in the Spike protein (Figure 1). It also contains many unique mutations. Here we describe the potential effects of each mutation on replication, immune evasion, and pathogenesis.
Mutations in R.1 found in other variants. Those in red are unique to R.1. ACCESS HEALTH INTERNATIONAL
The R.1 variant shares a common origin with all variants of interest or concern. They are marked by what I call the Triad, three mutations, one the 5’ untranslated region: C241U, a second in the viral polymerase NSP12: P323L, and the third D614G in the exterior S1 domain of the spike protein. The D614G mutation increases the infectivity. The contribution of the other two members of the Triad remains a mystery. Together these three mutations characterize the first major variant first observed in early 2020. That virus soon displaced almost all of the original Wuhan isolates. The Triad virus is the parent of all variants of concern or, interest including Alpha, Beta, Gamma, Delta, Lambda, and Mu. Only two currently circulating variants, A.30 and A.23.1, both of East Africa origin, lack the Triad and are most likely independent descendants of the original Wuhan virus.
The spike protein of SARS-CoV-2 binds the host ACE2 receptor and initiates infection. The R.1 variant contains three Spike mutations, two of which are previously noted in other variants the other which is unique.
(Excerpt) Read more at forbes.com ...
More fear porn.
Better question...thanks.
Disturbing just to you or the universe?
We need to drop a super variant in China like they did us.
If it was a variant it would have a Greek letter assigned ... R.1?
My post was one of Darth Vader’s famous lines from ‘Star Wars’. Remember?
Well, if the triad is the parent, and most variants have that triad, or two of the three, then wouldn't immunity towards Delta do the trick in protection since Delta is the harshest of the above ?
Got to keep up the fear porn at all costs. Humanity is now afraid of life and living.
Lol..sorry..I didn’t remember that. Flew right over my head lol.
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