Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Nature ^ | 09/09/2020 | Wen Shi Lee, Adam K. Wheatley, Brandon J. DeKosky

[Jan_Sobieski]

[…]

Conclusion

ADE has been observed in SARS, MERS and other human respiratory virus infections including RSV and measles, which suggests a real risk of ADE for SARS-CoV-2 vaccines and antibody-based interventions. However, clinical data has not yet fully established a role for ADE in human COVID-19 pathology. Steps to reduce the risks of ADE from immunotherapies include the induction or delivery of high doses of potent neutralizing antibodies, rather than lower concentrations of non-neutralizing antibodies that would be more likely to cause ADE.

Going forwards, it will be crucial to evaluate animal and clinical datasets for signs of ADE, and to balance ADE-related safety risks against intervention efficacy if clinical ADE is observed. Ongoing animal and human clinical studies will provide important insights into the mechanisms of ADE in COVID-19. Such evidence is sorely needed to ensure product safety in the large-scale medical interventions that are likely required to reduce the global burden of COVID-19…

[blueplum]

well, I’d dispute they’re a reaction to the vaccine since the most dangerous strains originated where there was no vaccine or only home remedies, contrary to the fearprofiteers claim. For instance there’s a CA, TX, NYC strain but they fizzled in the face of vaccination with only Delta able to get thru. Also, with nursing homes in the US being first vaccinated, with unvaccinated workers, thaat would logically be the first place for variants created by vaccinated to catch hold in the unprotected workers, but we’re not seeing that - just good old delta and not even a stronger version.

I will agree for sure that the mRNA vaccine is not optimal but then again the MMR childhood vaccine is 88% or so and that’s considered ok. China tried the ‘inactive’ virus route and that bombed bigtime. JJ and AZ use the adenovirus route and that’s not as good as mRNA. So mRNA is what we’re stuck with until we can find something else or move beyond the vaccine - maybe like monoclonals only a 6 day pill treatment like an antibiotic? I’m trying to stay optimistic that this pandemic will burn out and not become a thing where we even need to vaccinate. If the recovered stay at 80% immune and the vaccinated get to 80% (which I think we are close thanks to the old folks), we’ve got a good chance of wiping it out.

[Texas Fossil]

Your information sources and mine are worlds apart.

The solution will not come from the mRNA vaccines. First those using it don't want it to be over, they are using it to bring about their agenda.

The virus is man made. Fauci was/is involved.

Censorship is the enemy not the path to ending this virus. The Censorship is being boosted by Pure State Run Propaganda.

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“For instance there's a CA, TX, NYC strain but they fizzled in the face of vaccination with only Delta able to get thru.”

I don't believe that is true. The virus simply mutated. The vaccination never stopped it.

Where are you getting that information?

[Wuli]

“But it can’t all be blamed on vaccinated “

I did not blame it all on the vaccinated. What I did do was not “excuse” the vaccinated just because they are vaccinated because we know (a) the vaccinated ARE getting reinfected and (b) the vaccinated are, when reinfected, becoming infectious to others.

“ADE is a non-issue right now”. We do not know that at this time. There has not been enough study yet on how ADE may be part of why the vaccinated are getting reinfected, and it is important to identify that, and the sooner the better. Waiting for further developments is a wrong delay for that research.