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High-dose vitamin D (up to 80,000 IU)
Retarded. Excess vitamin D reduces vitamin K. People with low vitamin K do worse against the wuhan coronavirus.
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Good find, thanks.
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Instead of giving out free shots, why not give every American a free 30 day supply of HCQ and Ivermectin?
Of course no where in this is the perfect antibiotic that has been known thousands of years mentioned. Colloidal silver. The silver ion
The silver and doesn’t discriminate and kills all single celled organisms of which all pathogens are it has been documented to kill 650 known such
Here’s just one technical paper
idisciplinary Digital Publishing Institute (MDPI)
Antibacterial Activity of Colloidal Silver against Gram-Negative and Gram-Positive Bacteria
Andrea Vila Domínguez, Rafael Ayerbe Algaba, [...], and Younes Smani
Additional article information
Abstract
Due to the emergence of antimicrobial resistance, new alternative therapies are needed. Silver was used to treat bacterial infections since antiquity due to its known antimicrobial properties. Here, we aimed to evaluate the in vitro activity of colloidal silver (CS) against multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria. A total of 270 strains (Acinetobacter baumannii (n = 45), Pseudomonas aeruginosa (n = 25), Escherichia coli (n = 79), Klebsiella pneumoniae (n = 58)], Staphylococcus aureus (n = 34), Staphylococcus epidermidis (n = 14), and Enterococcus species (n = 15)) were used. The minimal inhibitory concentration (MIC) of CS was determined for all strains by using microdilution assay, and time–kill curve assays of representative reference and MDR strains of these bacteria were performed. Membrane permeation and bacterial reactive oxygen species (ROS) production were determined in presence of CS. CS MIC90 was 4–8 mg/L for all strains. CS was bactericidal, during 24 h, at 1× and 2× MIC against Gram-negative bacteria, and at 2× MIC against Gram-positive bacteria, and it did not affect their membrane permeabilization. Furthermore, we found that CS significantly increased the ROS production in Gram-negative with respect to Gram-positive bacteria at 24 h of incubation. Altogether, these results suggest that CS could be an effective treatment for infections caused by MDR Gram-negative and Gram-positive bacteria.
Keywords: multidrug-resistant bacteria, colloidal silver, Gram-negative bacteria, Gram-positive bacteria
1. Introduction
Infections caused by multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter, Staphylococcus spp., and Enterococcus spp. represent an increasing worldwide problem [1]. Currently, the appearance of MDR bacteria makes it impossible to find an effective drug to treat certain infectious diseases [2]. Therefore, there is an urgent need to find new therapeutic approaches in order to achieve better success in the bacterial infection treatment.
In this context, colloidal silver gained renewed interest. It was reported that colloidal silver can significantly reduce the duration and severity of many bacterial infections such as septic wounds [3]. This suspension of submicroscopic silver particles does not attack the bacteria directly, but causes a deactivation of enzymes responsible for their respiration, multiplication, and metabolism [4]. One of the main characteristics of silver is its oligodynamic effect, which is defined as the high microbicidal capacity of silver ions in water at a very low concentration (one part per million) [5]. Silver is an inert metal in its metallic form; however, it is biologically active when it is in the ionic monoatomic state (Ag+) soluble in an aqueous environment (water or tissue fluids) [6]. This activated ion shows a strong affinity for sulfhydryl groups and protein residues present in cell membranes [6].
Previous studies established four main mechanisms of action of silver ions: (i) destabilization of the cell membrane through the binding of silver ions to the sulfur atoms present in sulfhydryl groups of proteins and enzymes located on the bacterial cell surface [6,7,8], (ii) production of reactive oxygen species (ROS)
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