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Finland study: Antibodies present more than one year after COVID-19 infection [pre-print]
Outbreaknewstoday.com ^ | 22 Jul 2021 | NewsDesk

Posted on 07/30/2021 7:15:57 PM PDT by blueplum

...As many as 97% of subjects had IgG antibodies recognizing the coronavirus peak protein one year after infection. Although antibodies were detected in many, their levels after one year were about one-third lower than they had been six months after infection.

....A total of 1292 individuals were tested for antibodies six months after infection and 367 individuals one year later. Fifteen percent of those surveyed after six months and 13 percent of those surveyed after one year had had a serious coronavirus infection requiring hospitalization....

...Patients with severe disease requiring hospitalization had significantly higher levels of antibodies than those with mild disease. All patients with severe disease still had neutralizing antibodies after one year....

....The study also looked at the ability of the antibodies to neutralize altered viral forms. The amount of neutralizing antibodies against the Alpha variant was slightly lower compared to the virus strain and significantly lower against the Beta and Delta variants. Especially in patients with mild disease, the level of antibodies against viral variants was reduced....

(Excerpt) Read more at outbreaknewstoday.com ...


TOPICS: Chit/Chat; Health/Medicine
KEYWORDS: ccpvirus; covid; covidimmunity; finland; pandemic

1 posted on 07/30/2021 7:15:57 PM PDT by blueplum
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To: blueplum

pre-print:
https://www.medrxiv.org/content/10.1101/2021.07.13.21260426v1.full#T3


2 posted on 07/30/2021 7:16:16 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: blueplum

from the study narrative:
“ A previous study found that patients older than 60 years had fewer memory B cells secreting total IgG and RBD-specific IgG than patients under 60 years old nine months after infection (8). In this study we observed that IgG concentrations declined from six to twelve months more substantially in subjects ≥60 years compared to younger age groups. Similar more rapid decline in neutralizing antibody concentrations was observed among elderly compared to younger subjects who were followed up to six months following vaccination (43). The results of our study support previous findings indicating that protection against infection mediated by neutralizing antibodies may be impaired against the variants of concern, especially after a mild disease”


3 posted on 07/30/2021 7:20:52 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: blueplum

“The protection against serious disease that results from infection or vaccination is based not only on antibodies but also on cell-mediated immunity and memory cells that activate and produce antibodies when they encounter a pathogen,” Melin explains.

That’s the take home.

Good to see more study of natural infection immunity.
Been a few studies that showed it’s very good, and greatly enhanced by vaccination either before or after the infection, but the more the better.


4 posted on 07/30/2021 7:30:03 PM PDT by mrsmith (US MEDIA: " Every 'White' cop is a criminal! And all the 'non-white' criminals saints!")
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To: blueplum

“The protection against serious disease that results from infection or vaccination is based not only on antibodies but also on cell-mediated immunity and memory cells that activate and produce antibodies when they encounter a pathogen,” Melin explains.

That’s the take home.

Good to see more study of natural infection immunity.
Been a few studies that showed it’s very good, and greatly enhanced by vaccination either before or after the infection, but the more the better.


5 posted on 07/30/2021 7:30:04 PM PDT by mrsmith (US MEDIA: " Every 'White' cop is a criminal! And all the 'non-white' criminals saints!")
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To: blueplum

So to keep your immunity up you need exposure to the virus? Sounds a lot like what veterinarians call heard immunity. Just today I spoke to a retired professor of veterinary medicine about this subject. He was lead of one of the the largest clinic of its kind in the nation. He doesn’t believe anything in the news anymore because it’s all propaganda. He trusts nothing from Washington. Natural immunity is real and not being counted by the undereducated idiots on MSDNC, Fox, CNN, See BS etc. It’s a con job.

You really don’t need to respond because most of you see through the BS anyhow.


6 posted on 07/30/2021 7:32:36 PM PDT by packagingguy (Kit)
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To: blueplum
their levels after one year were about one-third lower than they had been six months after infection.

Shouldn't this be expected? I would need explanation from someone trained in the field but I thought for the most part the lasting immunity comes from memory T-cells that remember how to create antibodies, not specifically just from antibodies present in the blood. My understanding was that the antibodies show a positive reaction to infection, but the body remembers it long after the antibodies leave. I am open to corrections or clarifications.

7 posted on 07/30/2021 7:32:42 PM PDT by monkeyshine (live and let live is dead)
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To: blueplum

This is exactly why I got vaxxed 6 months after a mild case. I did not get the 2nd dose because I believe that they are spaced too close together and that’s why the 2nd dose has a high level of complications and complaints.

I plan to get a 2nd one at 6 months as a booster. Unless, of course, Delta fizzles into nothing leaving the CDC looking like the morons they are.


8 posted on 07/30/2021 7:35:53 PM PDT by Valpal1
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To: monkeyshine

You have it correct. The body retains a memory to respond as necessary but doesn’t register detectable anti-bodies beyond the year-long study from Finland.

T-cells may but have a similar testing regimen under the same timeframe.

Most Americans have natural immunity. Estimates are fully one-third already had the virus whether they are aware or not.

Avoid the vax. It’s experimental, demonstrates problems with blood clotting and smaller ones undetected are even more problematic long term.

The damage to the hearts of young people is especially tragic. It’s permanent.

Again, do not take the vax.


9 posted on 07/30/2021 8:22:23 PM PDT by romanesq (TRUSTY THE PLAN! ChiCom Joe is the Plan? Que magnificent! 👹)
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To: romanesq

Ok...I’ve not had the shot...and thru giving blood, the tests the Red Cross did say (over the past year 3x) “negative” (or not detectable)...sooo...how do I get some antibodies?...I’m not a recluse...mingle around stores, restaurants, etc.


10 posted on 07/30/2021 8:40:45 PM PDT by goodnesswins (The issue is never the issue. The issue is always the revolution." -- Saul Alinksy)
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To: monkeyshine

It should and I think this study upholds that view.

It also tentatively adds to the position severe disease means higher future immunity than mild/asymptomatic disease and that even wild acquired immunity (age-dependent and possibly sex dependent) has reduced resistance to stronger variants, that is, no apparent advantage for prior asymptomatic infection over vaccines.

” higher mean N-IgG, SFL-IgG and IgG-RBD concentrations in subjects who had recovered from severe disease than in those with mild disease six months after infection (p<0.001; Figure 3). The difference was 2.0 to 7.4-fold, depending on the age group, and persisted for at least twelve months after infection” Further down it says that it was males in the mild infection category that saw the largest drop.

“the subjects recovered from severe disease had overall 2.1 to 3.0-fold NAb titers compared to those with mild disease “

“Even though NAbs persist relatively long in most subjects, neutralization efficiency against Alpha (B.1.1.7), Beta (B.1.351) and Delta (B.1.617.2) variants was decreased compared to the wild-type virus. This was emphasized in subjects who had recovered from mild disease which is concerning since mild symptomatic individuals represent the majority of COVID-19 cases (1). Indeed, NAbs may not be developed in mild symptomatic or asymptomatic individuals and may also wane relatively quickly after infection (31).


11 posted on 07/30/2021 9:10:09 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: goodnesswins

In all likelihood, if you are healthy, under 65 and avoid the highest risk factors: obesity, diabetes and heart/lung issues, you can beat it.

You likely as the majority of Americans have natural immunity. You may have had the ChiCom Virus and like money never knew it.

This is vastly on the whole a nursing home disease. But, even there, it’s a 94% survival rate.

Everyone else, it’s about 99.8%.


12 posted on 07/30/2021 9:11:11 PM PDT by romanesq (TRUSTY THE PLAN! ChiCom Joe is the Plan? Que magnificent! 👹)
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To: mrsmith

better off without the death shot

but that kinda goes without saying


13 posted on 07/30/2021 9:22:34 PM PDT by Secret Agent Man (Gone Galt; Not Averse to Going Bronson.)
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To: blueplum

And 50 years later, the antibodies won’t show up, but if exposed to the virus the body will crank ‘em up!


14 posted on 07/31/2021 9:42:32 AM PDT by JimRed (TERM LIMITS, NOW! Militia to the border! TRUTH is the new HATE SPEECH.)
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