Journal of Controlled ReleaseI wonder how much efficacy improvement you get by spray freeze drying versus normal pulverization. Could you crush tablets in a mortar and pestle and use that resulting powder with similar efficacy?
Volume 300, 28 April 2019, Pages 93-101Spray freeze drying: Emerging applications in drug delivery
By D. A. Vishali, J. Monisha, S.K. Sivakamasundari, J. A. Moses, and C. AnandharamakrishnanAbstract
Spray freeze drying is relatively a recent drying technique involving heterogeneous set of steps which includes droplet formation, freezing, and sublimation. It has proven benefits over other drying methods in terms of producing products with improved structural integrity, superior quality, and better shelf stability. With such merits, spray freeze drying has found numerous applications in the field of drug delivery. Spray freeze drying yields particles of sizes and densities that show higher stability in the lungs, nasal mucosa, intestine, and skin, as compared to other drying technologies. These particles also possess the vital trait of sustained release and specificity through various delivery routes as compared to conventional drying techniques.
