Posted on 07/19/2021 7:08:19 AM PDT by CondoleezzaProtege
A comprehensive analysis of adverse events during clinical trials and over the course of mass vaccinations with the Sputnik V vaccine coronavirus showed that there were no cases of cerebral venous sinus thrombosis (CVST).
All vaccines based on adenoviral vector platform are different and not directly comparable. In particular, AstraZeneca’s ChAdOx1-S vaccine uses chimpanzee adenovirus to deliver the antigen, consisting of S-protein combined with leader sequence of tissue-type plasminogen activator. The vaccine from Johnson&Johnson uses human adenovirus serotype Ad26 and full-length S-protein stabilized by mutations. In addition, it is produced using the PER.C6 cell line (embryonic retinal cells), which is not widely represented among other registered products.
Sputnik V is a two-component vaccine in which adenovirus serotypes 5 and 26 are used. A fragment of tissue-type plasminogen activator is not used, and the antigen insert is an unmodified full-length S-protein. Sputnik V vaccine is produced with the HEK293 cell line, which has long been safely used for the production of biotechnological products.
Thus, all of the above vaccines based on adenoviral vectors have significant differences in their structure and production technology. Therefore, there is no reason and no justification to extrapolate safety data from one vaccine to safety data from other vaccines.
The quality and safety of Sputnik V are, among other things, assured by the fact that, unlike other vaccines, it uses a 4-stage purification technology that includes two stages of chromatography and two stages of tangential flow filtration. This purification technology helps to obtain a highly purified product that goes through mandatory control including the analysis of free DNA presence. In addition, the volume of nucleic acid is several dozen times lower in adenoviral vectors compared to Pfizer and Moderna vaccines (1 to 2 mcg vs 50 to 100 mcg, correspondingly).
A study published in The New England Journal of Medicine on April 9, 2021, discusses that the cause of the thrombosis in some patients vaccinated with other vaccines could be insufficient purification that leads to the emergence of significant quantities of free DNA. Insufficient purification or use of very high doses of target DNA/RNA can result in adverse interaction of a patient’s antibodies that activate thrombocytes with elements of the vaccine itself and/or free DNA/RNA, which can form a complex with the PF4 factor.
Link to the study:
https://www.nejm.org/doi/full/10.1056/NEJMoa2104840?query=featured_home
The Gamaleya Center is ready to share its purification technology with other vaccine producers in order to help them minimize the risk of adverse effects during vaccination.
Sputnik V - (double dose) consists of two different adenoviruses that require delivery by two separate vaccinations. Both doses contain non-replicating viral vectors. The first uses adenovirus type 26 (AD26), and the second — contains adenovirus type 5 (AD5).
Sputnik Light - (single dose) is the first component (recombinant human adenovirus serotype number 26 (rAd26)) of Sputnik V
Ping!
Thank You for posting!
The difference between Russia and us is that while we are dumb enough to embrace the population culling agenda Russia will not.
EpiVacCorona - Peptide-based vaccine.
CoviVac - Inactivated whole COVID-19 virus.
Thanks what have been the responses and reactions to the other 2?
From my perspective, Sputnik Light is a great option for the great mass of people without co-morbidities and strong immune systems. It’s a shame that it’s not an option here in the US. :(
I trust Russian vaccines as much as I trust Appalachian gas station sushi
If anyone has the “Russian Covid Vaccine for Dummies” version, I wouldn’t complain if you posted it.
They beat us by 3 months.
They have the biggest global market share.
Their vaccine costs less than half, and US pharma is already planning on jacking up the price even more.
Now they’re basically claiming that it’s a safer vaccine too.
Sure, this is an add... But I’d claim they spanked us.
But no worries. The pharma/health care industry is the world’s most protectionist. Unless you’re in some place like Mexico, your choice “in this free market” will be Pfizer, Moderna or Johnson and Johnson. What you want doesn’t matter. Someone else decides for you. You just need to pay up.
LOL. You win the thread!
“Sputnik V vaccine”
C’mon man, tell me that they didn’t really named their vaccine “Sputnik V”.
V-—GER envy.
Even Cuba isn’t taking this Shiite.
“CoviVac - Inactivated whole COVID-19 virus“
I had not heard of this one, thank you. Glad to see someone trying a traditional type vaccine, instead of the new systems that were not so great in trials pre covid.
I still believe covid never rose to the level of needing a rushed traditional vaccine much less an experimental one.
America wants to push the vax, and none of them are a traditional attenuated virus vaccine. You would think there may be a market for the traditional type vaccine.
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