(A) So the mRNA can be encapsulated in the lipid nanoparticles for protection from enzymatic degradation. A positively charged lipid nanoparticle favors localization of mRNA at the negatively charged cell membrane, including subsequent endocytosis into the cytosol. In order to be transcribed, the mRNA must escape both the lipid nanoparticle and the endosome.
(B) Extracellular proteins based vaccines are endocytosed in a similar manner, but do not need to escape from the endosome to be presented on MHC Class II molecules which are a class of major histocompatibility complex molecules normally found only on professional antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. These cells are important in initiating immune responses.
But answer me this; why did they say that hydroxychloroquine, & ivermectin were not only ancedotal, but dangerous to use, when they knew damn well that they both were not only safe, but also effective against coronaviruses?
Furthermore, why are they in such a push to vaccinate 100% of the population?
While you may think that lipid nanoparticles can only be used for good, you better do further research. Anything that has a positive, always has a negative associated with it also.
Lastly, why have they not given these vaccines their stamp of approval if they are safe and effective? How many have to die before we slow down the vaccination process? If they say that the vaccines are not the cause, where are the autopsies?
Money is the main motivation. They trashed what could have been a cheap & effective tool to combat this novel coronavirus. If they give these vaccines FDA approval, then the manufactures can be sued, so they will not do that right now. But their reasons go far beyond just the money aspects. One we can all agree on was to use the virus to interfere in an election process to take down a president both parties didn't like, and they had to do it so clumsily that enough people saw it and complained. The big tech entities also assisted in many ways, such as controlling the flow of information, as well as, millions in money illegally infused into the voting process.
There is also good reasons for fearing vaccines that have caused many deaths worldwide, while deaths from the virus, while dangerous to some, barely register with the majority of people. They used the virus to destroy world economies. So what are they going to do with the many people now suffering, not from the virus, but from a storm of epic proportions with supply chains falling apart, and food supplies rapidly becoming an issue.
Like I said you are not nearly as smart as you believe yourself to be. Besides that you are a hypocrite of epic proportions. By being condescending towards me of something I posted that may or may not (most likely not) a valid concern. That is what discussion is about, and that is how we learn.
However, when I treat you in kind as you treated me, you then further beat your chest stating you are intelligent and I am nothing more than a tinfoil wearing idiot. You better look in the mirror to see who the real idiot is here.
I can answer all of your questions. However, it has been my experience with those who are opposed to the mRNA vaccine to find some flaw in my wording and use it to destroy the entire narrative. This is what is called the composition fallacy: something is true of the whole from the fact that it is true of some part of the whole. A trivial example might be: “This tire is made of rubber, therefore the vehicle of which it is a part is also made of rubber.
You asked: “why did they say that hydroxychloroquine, & ivermectin were not only ancedotal, but dangerous to use, when they knew damn well that they both were not only safe, but also effective against coronaviruses? , & ivermectin were not only ancedotal, but dangerous to use, when they knew damn well that they both were not only safe, but also effective against coronaviruses?”
Answer: When people first began using HCQ and Ivermectin for COVID infection, both were being used for treatments for other diseases. Those diseases were not viral infections. HCQ works by killing the organisms that cause malaria and it also to treat rheumatoid arthritis and systemic lupus erythematosus by decreasing the activity of the immune system. Even though it showed promise in treating COVID not much was understood how zinc played an important part in its effectiveness against COVID.
Medical science is very methodical and each step of the analyses must be thoroughly made. People on the outside can get very frustrated when the answers seem so obvious. In my mind, HCQ allowed a pathway for the zinc to enter the cell where it interfered with the transcription process. HCQ may also interfere with the docking process with the ACE-II receptor. That had to happen early on in the infection, before the virus was able to trigger the cytokine storm, which kills the victim. All the workings of HCQ had to be understood perfectly, so they can know how to use it. And everyone wanted FDA approval for it at warp speed. I am not sure, even now, if my doctor knows what the proper dose I should take if I ever needed it for Covid.
The U.S. government should have financed the clinical trials for HCQ and Ivermectin early on, but they trusted that the vaccine producers could have a better solution with their vaccines. Ivermectin is now in clinical trials. It is just that methodical thinking which many don’t understand.
I talked to my doctor about Ivermectin. He said I could not get a prescription for it through the Kaiser Permanente system. None of the doctors would prescribe it because it is still in clinical trials. How can that be? Ivermectin is having miraculous results in other parts of the world. Medical science is very methodical. They learned during the 80s when the malpractice lawsuits were epidemic, that increased caution in medical treatment was essential. Malpractice insurance went sky high. I suspect that lawsuits against Phizer and Moderna are in the works right now.
No, I am not a Dem. I have been a Republican since Richard Nixon. I have been an elected Republican Precinct Officer for 17 years and have risen to be GOP Vice Chair of my legislative district. My understanding of the virus and the vaccines has been a self-taught hobby. I still have a lot to learn. Nothing is 100% perfect for me. The harsh treatment I get when FReepers get mad because it is not in line with the anti-vaxx narrative is a good thing. When I am fighting against the Leftnicks in the Seattle area, I need to be tough.
Why do they want a 100% vaccination of the population?
Answer: They want to take the virus to the same place that they took Measles, Mumps, Smallpox, Polio, Chicken Pox,Tetanus, Hepatitis B (soon to be eliminated in the U.S.), Hepatitis A (soon to be eliminated in the U.S.), Rubella, Haemophilus influenzae type b (Hib), Whooping Cough, Pneumococcal Disease, Haemophilus influenzae type b, and Diphtheria. Vaccines have been one of the greatest accomplishments of mankind. I can hardly wait to see how this mRNA/lipid nanoparticle technology plays out in personalized cancer vaccines and other diseases, now in clinical trials.
The Covid vaccines have shown their effectiveness with the New Delta Variant striking only unvaccinated people. I could have used the word “mostly” but this is how it is being described. If this new strain lacks the morbidity, that would be good because of the natural immunity effect.