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New microfluidic device delivers mRNA nanoparticles a hundred times faster
Phys.org ^ | JULY 7, 2021 | Evan Lerner, University of Pennsylvania

Posted on 07/07/2021 5:00:17 PM PDT by BenLurkin

Because any desired mRNA sequence can be synthesized in massive quantities, one of the biggest hurdles in a variety of mRNA therapies is the ability to package those sequences into the lipid nanoparticles that deliver them into cells.

The researchers' advance stems from their design of a proof-of-concept microfluidic device containing 128 mixing channels working in parallel. The channels mix a precise amount of lipid and mRNA, essentially crafting individual lipid nanoparticles on a miniaturized assembly line.

This increased speed may not be the only benefit; more precisely controlling the nanoparticles' size could make treatments more effective. The researchers tested the lipid nanoparticles produced by their device in a mouse study, showing they could deliver therapeutic RNA sequences with four-to-five times greater activity than those made by conventional methods.

This platform technology, called Very Large Scale Microfluidic Integration (VLSMI), allows tens of thousands of microfluidic units to be incorporated into a single three-dimensionally etched silicon-and-glass wafer.

These parallelized mixing channels allow VLSMI to have the potential to achieve the liter-per-hour production rates necessary for vaccine manufacture. Flow resistors ensure that every mixing channel receives the same flow conditions and ratio of lipids and RNAs across the device, producing the uniform nanoparticles critical for vaccine and therapeutic applications...

(Excerpt) Read more at phys.org ...


TOPICS: Health/Medicine
KEYWORDS: microfluidic; mrna; nanoparticles; scamdemic

1 posted on 07/07/2021 5:00:17 PM PDT by BenLurkin
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To: BenLurkin

Well, it won’t take “Ten Percent for the Big Guy” long to make sure this developing intellectual property to the ChiComs.


2 posted on 07/07/2021 5:08:22 PM PDT by House Atreides
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To: BenLurkin

Just like how the Borg assimilate people.


3 posted on 07/07/2021 5:12:54 PM PDT by mikey_hates_everything
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To: BenLurkin

Invasion of the Body Snatchers comes to mind.


4 posted on 07/07/2021 5:16:26 PM PDT by E. Pluribus Unum ("Communism is not love. Communism is a hammer which we use to crush the enemy." ― Mao Zedong)
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To: BenLurkin

Screws you up 100 times faster.


5 posted on 07/07/2021 5:37:32 PM PDT by beethovenfan (Mene, Mene, Tekel, Upharsin)
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To: All

Oh, goodie! I was afraid that turning everyone into zombies would take decades!!!


6 posted on 07/07/2021 5:38:46 PM PDT by LegendHasIt
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To: beethovenfan

Instant

Zombie


7 posted on 07/07/2021 5:39:07 PM PDT by BenLurkin (The above is not a statement of fact. It is either opinion, or satire. Or both.)
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To: BenLurkin

Like the Dean Koontz book where scientists accidentally un-bind DNA and it starts drifting between people, animals and plants.


8 posted on 07/07/2021 10:40:12 PM PDT by \/\/ayne (I regret that I have but one subscription cancellation notice to give to my local newspaper)
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To: BenLurkin

Isn’t this the same sort of stuff that has been found in the so-called vax?


9 posted on 07/07/2021 11:15:11 PM PDT by LastDayz (A blunt and brazen Texan. I will not be assimilated.)
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To: BenLurkin

Civilizations crash and burn when knowledge gets too far ahead of wisdom. We came close with the development of nuclear technology. It’s not clear we’ll survive the early days of genetic reprogramming technology. Especially not with this sort of attitude.


10 posted on 07/08/2021 2:53:01 PM PDT by AustinBill (consequence is what makes our choices real)
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