A man who boosted his Pfizer COVID-19 vaccine with a shot from Moderna said his side effects were a 'little more severe' the third time round

Business Insider ^ | June 19 2021 | Hilary Bruseck

[CondoleezzaProtege]

Hyser is one of the first Americans to participate in a groundbreaking COVID-19 mix-and-match study, aimed at assessing whether boosters work, and whether different COVID-19 shots are safe — and possibly more effective — when they're mixed together.

For now, the study is boosting only with a single dose of Moderna's vaccine, whether participants' first shots were from Moderna, or from Pfizer or Johnson & Johnson — the other two US-authorized vaccines. Other combinations of the vaccines, and which order they're taken in, will be added in to the study later on.

Study participants will get routine blood draws (Hyser already had his first), and initial results could be ready within months.

A big question this study will explore is whether boosting people who've had J&J's one-shot adenovirus vaccine with Moderna's mRNA shot might make the performance similar.

While Hyser's Moderna side effects were a little more intense, he said they faded with some ibuprofen and a day of rest.

"I did, for Pfizer, have a little bit of chills, a little bit of muscle ache, but nothing that prevented me from conducting my normal day to day activities," he said, remembering how the day after his second shot in January he did some work, went grocery shopping, and made a pot of chili.

"With the booster, it was a little bit more severe," he said, describing waking up the day afterwards feeling "like I had done a very rigorous gym workout," with chills and arm soreness like he'd gotten a "hard punch in the shoulder." He popped some ibuprofen, which helped ease the aches, and by the following day, he felt like himself again

[2aProtectsTheRest]

Right you are! That particular scene with the rooftop party was Los Angeles. Great memory. It’s been a long time since I’ve actually seen this one.

[StAnDeliver]

"I live in a very liberal part of Houston and have never once had anyone yell at me when I’m outside without a mask."

Oh, in Houston. Got it. Like Pasadena lofl. Schadenfreude.

There's the door. Show yourself out.