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The Necessity of COVID-19 vaccination in previously infected individuals: Individuals who have recovered from SARS-CoV-2 infection are unlikely to benefit from COVID-19 vaccination
MedRxIV ^
| 06/08/2021
| View ORCID ProfileNabin K. Shrestha, Patrick C. Burke, Amy S. Nowacki, Paul Terpeluk, Steven M. Gord
Posted on 06/08/2021 9:12:20 PM PDT by SeekAndFind
ABSTRACT
Background The purpose of this study was to evaluate the necessity of COVID-19 vaccination in persons previously infected with SARS-CoV-2.
Methods Employees of the Cleveland Clinic Health System working in Ohio on Dec 16, 2020, the day COVID-19 vaccination was started, were included. Any subject who tested positive for SARS-CoV-2 at least 42 days earlier was considered previously infected. One was considered vaccinated 14 days after receipt of the second dose of a SARS-CoV-2 mRNA vaccine. The cumulative incidence of SARS-CoV-2 infection over the next five months, among previously infected subjects who received the vaccine, was compared with those of previously infected subjects who remained unvaccinated, previously uninfected subjects who received the vaccine, and previously uninfected subjects who remained unvaccinated.
Results Among the 52238 included employees, 1359 (53%) of 2579 previously infected subjects remained unvaccinated, compared with 22777 (41%) of 49659 not previously infected. The cumulative incidence of SARS-CoV-2 infection remained almost zero among previously infected unvaccinated subjects, previously infected subjects who were vaccinated, and previously uninfected subjects who were vaccinated, compared with a steady increase in cumulative incidence among previously uninfected subjects who remained unvaccinated. Not one of the 1359 previously infected subjects who remained unvaccinated had a SARS-CoV-2 infection over the duration of the study. In a Cox proportional hazards regression model, after adjusting for the phase of the epidemic, vaccination was associated with a significantly lower risk of SARS-CoV-2 infection among those not previously infected (HR 0.031, 95% CI 0.015 to 0.061) but not among those previously infected (HR 0.313, 95% CI 0 to Infinity).
Conclusions Individuals who have had SARS-CoV-2 infection are unlikely to benefit from COVID-19 vaccination, and vaccines can be safely prioritized to those who have not been infected before.
Summary Cumulative incidence of COVID-19 was examined among 52238 employees in an American healthcare system. COVID-19 did not occur in anyone over the five months of the study among 2579 individuals previously infected with COVID-19, including 1359 who did not take the vaccine.
Competing Interest Statement
The authors have declared no competing interest.
Funding Statement
There was no funding for this study.
Author Declarations
I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Yes
The details of the IRB/oversight body that provided approval or exemption for the research described are given below:
The study was approved by the Cleveland Clinic Institutional Review Board. A waiver of informed consent and waiver of HIPAA authorization were approved to allow access to personal health information by the research team, with the understanding that sharing or releasing identifiable data to anyone other than the study team was not permitted without additional IRB approval.
All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.
Yes
Data Availability
De-identified subject-level data and code to reproduce the results are available on a public data repository.
https://osf.io/k7wtv/
TOPICS: Health/Medicine; Science; Society
KEYWORDS: covax; covid19; naturalimmunity; sarscov2; vaccination
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To: SeekAndFind
2
posted on
06/08/2021 9:13:19 PM PDT
by
Salvavida
To: Salvavida
No sale on the conclusion....that pre-Covid people don’t need the vax? Or, no sale on the vax, period?
3
posted on
06/08/2021 9:15:59 PM PDT
by
Jane Long
(America, Bless God....blessed be the Nation ππ»πΊπΈ)
To: SeekAndFind
To: SeekAndFind
Current testing does not determine if a patient has T cell immunity. Even more important there is no test to determine a given individuals genetic susceptibility or resistance. Generally speaking an immunoligically competent individual does not get infected with the same virus twice. However if a virus has found sanctuary somewhere in the body ( as is the case with varicella or chicken pox), it can reappear in different clinical forms ( shingles in the case of chicken pox). In those cases vaccines have been useful in keeping the virus suppressed. In some patients with persistent symptoms post COVID infection such as “brain fog”,fatigue and cough, the symptoms in some patients resolved after receiving the vaccine.
There is still much to learn about this virus and the true scope of infection in affected individuals. Does it find sanctuaries and persist? Why do some people get exposed but have the genetic capability to totally resist infection? Why do some infected individuals have a very mild clinical course and others go into respiratory failure and die?
Know its not a popular position with some Freepers but given the fact that many of the variants are demonstrating enhanced infectivity, but thus far are stopped by the vaccines, strongly suggest that unvaccinated adults consider seriously getting the vaccine.
5
posted on
06/08/2021 9:35:23 PM PDT
by
allendale
To: Jane Long
No sale on the vax period. Primarily, it isn’t a vaccine. It is a technology that has killed every single animal in trials.
Secondly, the human body is the greatest virus killing machine....if you know how to tune it. There are safer effective options.
Third, why do they care if I am vaxed or not as long as they believe in the jab?
Forth, by their own guidance, this poison should have been pulled after 25 deaths. We are well past that.
Fifth. In a small state funded caregiving home for brain injuries my wife worked at, the amount of adverse reactions on residents and staff for such a small population was staggering.
Hard pass.
6
posted on
06/08/2021 9:38:05 PM PDT
by
Salvavida
To: Salvavida
Okay, good!
All the things MANY of us have been saying, for months, here.
(I was thinking maybe you meant no sale to the conclusion/headline :)
7
posted on
06/08/2021 9:41:21 PM PDT
by
Jane Long
(America, Bless God....blessed be the Nation ππ»πΊπΈ)
To: SeekAndFind
Does not matter. They still need to be forced to comply and submit (to the jab) to prove they are good citizens, and not be thought bad of by the indoctrinated CNN viewing crowd.
8
posted on
06/08/2021 9:41:27 PM PDT
by
Sir Bangaz Cracka
(Slamming dat white cracka'a head into dat sidewalk causin he be scared)
To: SeekAndFind
"95% CI 0 to Infinity"LOL. They are only 95% confident the real answer lies between zero and infinity? Are they paying too much attention to Buzz Lightyear "To infinity and BEYOND"? Is the other 5% beyond infinity?
I'm not sure about my own Confidence Interval for the research team that wrote that.
9
posted on
06/08/2021 9:41:32 PM PDT
by
ProtectOurFreedom
("Pour les vaincre il faut de l'audace, encore de l'audace, toujours de l'audace")
To: CondoleezzaProtege
Yes, even the variants.
More so than the experimental shots, anyway.
Worst case....keep Ivermectin on hand, but...being pre-infected/CV antibody positive, you likely wouldn’t need it.
Are you worried about the variants?
10
posted on
06/08/2021 9:43:03 PM PDT
by
Jane Long
(America, Bless God....blessed be the Nation ππ»πΊπΈ)
To: allendale
I am going in for my yearly check up on Thursday. My doctor's office charges 50% to 100% more for the same exact tests from the same exact lab than if I order them myself online. So since we live in a hotspot and I was exposed to Covid numerous times in the past year and a half, I paid an extra $59 for a Covid antibody test.
I was shocked that it came back negative. I have concluded from this that there are several explanations. Covid may not be not as contagious as we have been told. The test for antibodies may not be as sensitive as the over-sampled tests for active cases. Some people who are resistant may not develop antibodies despite having exposures.
I was one of the heads of a Hazmat Team for years. I have had multiple times more vaccinations than even most other firefighters. But after my mother nearly died after having the first Pfizer shot and still is an invalid months later... I wouldn't touch one of these experimental vaccines with a ten foot pole
To: Salvavida
“No sale on the vax period. Primarily, it isnβt a vaccine.”
Concur. In fact, there are numerous Virologists totally ignored by the MSM Worshipers of their hero Fauci that state that the “vaccines” that currently exist actually enhance the Wuhan Virus.
My wife and I just today received emails from our PCP telling us that the “vaccines” are now readily available and asking us to make an appt. to get the Jab.
I am Retired Military.
Our PCP is an active duty Military Doc. We both told him no thanks. We are Humans. With healthy immune systems. Not Guinea Pigs willing to be subjected to a Jab that to this very day is still classified as “EXPERIMENTAL”.
The response was, okay. Understood.
12
posted on
06/08/2021 10:01:49 PM PDT
by
ocrp1982
( Bibicly)
To: Jane Long
Yep, after all this time I cannot believe I haven’t been exposed to CV19. Odds are very in favor that I am now immune. So, for me, the risk that CV19 poses to me is far, far less than the risks of an experimental injection. Plus, I have HCQ and Ivermectin on hand. I rarely get sick, early sixties, can’t remember the last time I had a cold or flu, still refuse to get the annual flu shot.
13
posted on
06/08/2021 10:29:09 PM PDT
by
sageburn
To: Jane Long
I should also add I still stick to the old adage “if it ain’t broke, don’t fix it”. And jeez, I’m no expert, but daily more and more info is coming out that these “vaccines” are nasty stuff. I have much more confidence in my immune system than the crap in these experimental injections.
14
posted on
06/08/2021 10:33:58 PM PDT
by
sageburn
To: ocrp1982
To: Salvavida
What sort of adverse reactions did the residents and staff get from the shots?
Do those reactions get reported to the VAERS system?
16
posted on
06/08/2021 11:09:17 PM PDT
by
WildHighlander57
((WildHighlander57 returning after lurking since 2000))
To: Salvavida
Forth, by their own guidance, this poison should have been pulled after 25 deaths. We are well past that.
ββββββββββ-
The US and EU β reporting systemsβ have already -reported- 3,800 deaths in the US and 15,000 deaths by the jab in the EU....where is the outrage?
17
posted on
06/08/2021 11:29:59 PM PDT
by
delta7
To: WildHighlander57
Two nurses hospitalized. One with clots. One resident bleeding out the rear, another resident lost muscular control in the face and went cross-eyed, I guess a neurological issue.
One of the nurses was released, only to be hospitalized again one day later.
I know the nurses would have been reported. I am not sure about the residents because it appears the facility didn’t obtain permission from the parents/guardians to administer the jab. None of the residents have the mental capacity to consent to treatment. My wife suspects it was covered up for liability reasons.
To: Salvavida
β Fifth. In a small state funded caregiving home for brain injuries my wife worked at, the amount of adverse reactions on residents and staff for such a small population was staggering.β
Exactly, the viral spike proteins cross the blood/brain harrier in addition they are found in the circulation of every organ of the body.
The m-RNA injections are wreaking havoc!
I had a guy who had a pneumothorax 30 years ago in his right lung. After 2 vaccinations, his right lung has been destroyed. He now has an emphysema-like condition in that lung, but has never smoked nor lived with anyone who smoked. Essentially, those spike proteins coded for by viral m-RNA found a home in a previously damaged area and took it out! He was fully recovered and even was a runner. Now heβs on O2.
To: allendale
We’ve been lied to this entire time. This virus was foisted upon us intentionally with evil intent. Why would you listen to anything they tell you to do? One would have to be devoid of all intelligent thought to even consider it, or so stricken by fear that they lost their ability to reason.
20
posted on
06/09/2021 5:05:57 AM PDT
by
Bulwyf
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