Posted on 06/05/2021 7:47:10 AM PDT by ConservativeMind
Enhancing autophagy—the cellular process that breaks down and removes unneeded components—in fat tissue could help treat diabetes, according to a Northwestern Medicine study published in Cell Reports.
Beclin 1/Becn1, an autophagy-promoting protein, sensitized cells to insulin through a pathway involving the hormone adiponectin. Congcong He, Ph.D., assistant professor of Cell and Developmental Biology and senior author of the study, said that while certain aspects of the process require further study, this mechanism could be exploited to treat insulin resistance in diabetes.
"If there's something that mimics or enhances the function of adiponectin, that might be therapeutically effective against diabetes," said He, who is also a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
Autophagy plays a key role in a number of processes: removing long-lived and misfolded proteins, clearing damaged organelles, and regulating growth and metabolism. A major regulator of autophagy is a specific protein, Beclin 1.
In normal organisms, Beclin 1 is only activated under certain stress conditions, such as a lack of nutrients or oxygen. Activation of Beclin 1 triggers autophagy, recycling dysfunctional cellular structures and hopefully ameliorating the stressors that triggered the process in the first place.
"Metabolic tissues such as fat are likely to be more sensitive to autophagy than insulin-storing B cells, so the idea is that if you intermittently fast or exercise, it can activate autophagy in fat earlier than other parts of the body and be metabolically beneficial," He said.
(Excerpt) Read more at medicalxpress.com ...
It has been thought that misfolded proteins typically cannot be properly eliminated as we get older. They make up ever increasing proportions of our body.
so fasting is key?
Intermittent fasting and a Ketogenic diet.
Agree.
Intermittent fasting or eating a whole foods, plant based diet.
If diet caused an issue, diet can change the issue.
Roughly 80% of hospitalizations are due to what we put in our mouths.
I’ve just started back on 18/6 eating window and I’m working on less junk, more nutrient-dense plant based eating. Every weekday, I only eat from 1:00p through 7:00p, and always have a soup, a salad (huge with lots of veggies) and a smoothie so that I’m getting at least 10 different fruits and vegetables a day. Saturday I give myself some leeway so it’s maintanable and I don’t feel deprived.
It is NOT restricted to a vegan diet. Meats can be consumed as well!
How could a type 1 benefit from this?
Please, ENJOY your animals.
No one stopping you. :)
Good question.
Type 1 diabetics don’t have the same root cause route to diabetes. However, they are on a much more delicate routine to keep their bodies healthy.
Understand that I am not a doctor, but from what I have read, it would seem plausible that Type 1 diabetics would tend to not have nearly the issue Type 2 diabetic patients would have. Type 2 typically equates to quite a bit of weight gain, for instance, likely due to ignoring blood sugar/insulin levels/triglyceride levels versus that of Type 1 diabetics.
Intermittent fasting is something possible with both Type 1 and Type 2 diabetics, but Type 1 is even more in need of carefully approaching any sort of fasting. These approaches, with anyone with diabetes, must be done with your doctor’s help.
I will say that even Type 1 diabetics have been able to benefit from intermittent fasting. A number of resources describing how to approach this are here:
https://duckduckgo.com/?q=intermittent+fasting+type+1+diabetic
Hey... that is fantastic.
I am also on an intermittent schedule, from 10:00AM to 4PM, being my eating window, with a sort of brunch and an early dinner. This works perfect for me. :)
So says Congcong He, PHD.
It’s actually better than treating it, Diabetes can be reversed, is my understanding. Type II anyway. This is important, even if one is not Diabetic.
Intermittent Fasting, aka “time restricted” eating, isn’t necessarily “key”, what is important is simply burning off the excess fat and returning the body to balance. That’s what Autophagy is. One thing (fasting) does is reduce insulin levels, in a “normal” diet eventually the body becomes insulin resistant, aka metabolic syndrome and all those health problems it entails. Fasting also increases “opposite” hormones to insulin, and returns blood lipid parameters to normal ranges.
Intermittent fasting is probably the simplest (maybe even “easiest” if definitely not easy) to safely and rapidly lose the pounds, and shed fat. Nobody can out exercise their diet, the only way that works is to consume a lot less calories than required. The beauty of it for many people, you can eat what you want, instead of oak sawdust toast and brussel sprout smoothies. Exercise is a red-herring in my opinion, the key is calorie reduction. It’s beneficial in losing the fat, but the fact is it takes hours of activity to burn off trivial amounts of excess calories.
Of course run this by your Doctor first.
Bkmk
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