The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses

MedRxiv ^ | May 6, 2021 | F. Konstantin Föhse, View ORCID ProfileBüsranur Geckin, View ORCID ProfileGijs J. Overheul, View

[Cathi]

Little is known about the broad effects of the new class of mRNA vaccines, especially whether they have combined effects on innate and adaptive immune responses. Here we confirmed that BNT162b2 vaccination of healthy individuals induced effective humoral and cellular immunity against several SARS-CoV-2 variants. Interestingly, however, the BNT162b2 vaccine also modulated the production of inflammatory cytokines by innate immune cells upon stimulation with both specific (SARS-CoV-2) and non-specific (viral, fungal and bacterial) stimuli. The response of innate immune cells to TLR4 and TLR7/8 ligands was lower after BNT162b2 vaccination, while fungi-induced cytokine responses were stronger. In conclusion, the mRNA BNT162b2 vaccine induces complex functional reprogramming of innate immune responses, which should be considered in the development and use of this new class of vaccines.

In conclusion, our data show that the BNT162b2 vaccine induces effects on both the adaptive and the innate branch of immunity and that these effects are different for various SARS-CoV-2 strains. Intriguingly, the BNT162b2 vaccine induces reprogramming of innate immune responses as well, and this needs to be taken into account: in combination with strong adaptive immune responses, this could contribute to a more balanced inflammatory reaction during COVID-19 infection, or it may contribute to a diminished innate immune response towards the virus. BNT162b2 vaccine is clearly protective against COVID-19, but the duration of this protection is not yet known, and one could envisage future generations of the vaccine incorporating this knowledge to improve the range and duration of the protection.

[Paladin2]

“The human Body” [and all of the individual variants therein ] and the proclivity of virii to mutate quickly make for a very complex, dynamic system.

The CDC is NOT up to the task of being able to predict responses [as has been shown to date].

The “Experts” are not.

[metmom]

Thanks for posting this.

Ping

[nagant]

The leftist leaders’ big problems with these mRNA vaccines are that they: 1) are far more effective than past vaccines, 2) are far more effective against future variants, and 3) last longer, than older types of vaccines.

[Rurudyne]

Those things have certainly been asserted.

Try to find a successful long term trial with proper controls though.

[LesbianThespianGymnasticMidget]

1) are far more effective than past vaccines, 2) are far more effective against future variants, and 3) last longer, than older types of vaccines.

---

8 players on a MLB team have a teensy weensy tiny little issue with these statements. (New York Yankees)

https://www.nbcnews.com/news/sports/eight-yankees-test-positive-covid-post-vaccine-breakthrough-cases-n1267332

I had no idea you were such a good ventriloquist, nagant. I could swear you were talking out your ass.

[PGalt]

Thanks Cathi. How much do they know and when did they know it?

R.I.P. DG (horrific way to die 2 days after 2nd modeRNA vaccine shot)

[PGalt]

: ) thanks. I’ve got the documentation of the death of DG. this one hits very close to home.

[Cathi]

“How much do they know and when did they know it?”

__________________________________________________________________
https://www.fda.gov/media/143557/download

October 22, 2020

FDA Safety Surveillance of COVID-19 Vaccines : DRAFT Working list of possible adverse event outcomes ***Subject to change***

Guillain-Barré syndrome 

Acute disseminated encephalomyelitis 

Transverse myelitis 

Encephalitis/myelitis/encephalomyelitis/ meningoencephalitis/meningitis/ encepholapathy 

Convulsions/seizures 

Stroke 

Narcolepsy and cataplexy 

Anaphylaxis 

Acute myocardial infarction 

Myocarditis/pericarditis 

Autoimmune disease 

Deaths 

Pregnancy and birth outcomes 

Other acute demyelinating diseases 

Non-anaphylactic allergic reactions 

Thrombocytopenia 

Disseminated intravascular coagulation 

Venous thromboembolism 

Arthritis and arthralgia/joint pain 

Kawasaki disease 

Multisystem Inflammatory Syndrome in Children 
Vaccine enhanced disease

[wjcsux]

In before the pro-vaxx trolls.

[PGalt]

!

[bobcat62]

The Janssen (J&J) treatment operates differently than Fauci’s mRNA poison.

[upchuck]

I don’t care much about analysis from either direction.

My body, my choice. No “vaccine” for me. Quotes because it’s not a traditional vaccine. Rather it’s an unproven, experimental drug that messes with your mRNA and DNA.

I doubt that God would approve.

[thecodont]

Thanks for this article.

[Organic Panic]

Read the first sentence several times.

Then ask yourself why there is a world wide propaganda campaign to get healthy peopl, or people who have naturally recovered get the shot,

[Jane Long]

Thanks for the ping.....to read after dinner :-)

[Steve Van Doorn]

This sums up all the interim reports.

Peer-reviewed research from @TheLancet
shows that the experimental vaccines reduce your chance of catching COVID-19 by:
Pfizer: 0.8%
Johnson & J: 1.2%
Moderna: 1.2%
AstraZeneca: 1.3%
So, basically NO prevention
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057721/

[Rurudyne]

I view them as easily weaponizable gene therapy sold as vaccines.

This is probably rooted in population control or transhumanism or both.

[jonrick46]

This vaccine advance is great news. That ol’ pesky virus is getting the vaccine one-two punch. Add that to the use of Ivermectin and we will kick that dog when it is on the ground.

[JamesP81]

Who is DG?