(Study intervention = 'vaccine') Sure sounds like the 'vaccine' itself is contagious via inhalation or skin contact. https://media.tghn.org/medialibrary/2020/11/C4591001_Clinical_Protocol_Nov2020_Pfizer_BioNTech.pdf
Posted on 05/22/2021 12:05:25 AM PDT by definitelynotaliberal
Two of the three COVID-19 vaccines that have been authorized so far in the United States use synthetic messenger RNA, or mRNA, to protect against the coronavirus. Though these vaccines — developed by Pfizer and Moderna, respectively — are the first of their kind to be used at this scale, this historic moment would not be possible without the decades of research that came before it.
There are lots of different ways to make a vaccine, but the ultimate goal of any shot is to introduce the body to the biological equivalent of a “most wanted” poster so that if the real enemy ever shows up, our immune systems know how to fight it off.
For some vaccines, that poster is a version of a pathogen that’s been weakened — like the chickenpox shot — or inactivated — like most flu shots — so that it can’t actually cause infection. For others, including the HPV and shingles vaccines, it’s a piece of that pathogen, like the specific protein it uses to infect cells in the first place.
But mRNA vaccines take a different approach. Rather than tinkering with the virus or its parts, this platform harnesses the “beauty of our biology” to deliver protection, said RNA virologist Paul Duprex, who directs the University of Pittsburgh Center for Vaccine Research. These vaccines teach the body to remember one of the coronavirus’ defining features — its spike protein — and prompt the creation of antibodies that can prevent it from infecting cells.
Our DNA resides inside the nucleus of our cells. Every day, mRNA molecules constantly carry genetic information coded in that DNA from the nucleus to the parts of the cells, called ribosomes, that can interpret those messages and then make the proteins that carry out essential biological processes. Without it, life would be impossible.
“Pretty much every single cell in my body at this particular moment is producing billions and billions and billions of messenger RNAs,” Duprex said.
Vaccines that use synthetic mRNA add one more type of mRNA to the legion of other molecules “doing their daily business” within our bodies, and use it “to make a protein which the immune system will see and make antibodies against and protect us from a disease,” Duprex added.
Around 20 years ago, the work of two researchers — Drew Weissman and Katalin Karikó — helped overcome two primary barriers that had been standing in the way of utilizing mRNA technology: an inflammatory effect on the body that made test animals ill, and the fragile nature of the molecule itself, both of which hindered its utility.
Despite those advancements, and the wealth of research that’s been carried out since, the fact remains that the two mRNA vaccines in use today are the first of their kind. That may be in part because it’s difficult to generate interest and funding to support pursuing “non-mainstream” science outside of a crisis, Duprex said — what he characterized as “a shortsighted way to think about biology.”
Only now, amid a devastating pandemic, has this technology reached mainstream prominence. “Given the choice, I would have rather avoided this past year,” Weissman said. “But we didn’t, and now RNA is going to be our future.”
Here’s a look at how, exactly, these vaccines manage to pull off this feat and some of the key research breakthroughs that made this moment possible. How messenger RNA vaccines work
In order to develop these vaccines, researchers took the RNA-based genetic sequence of the coronavirus and turned it into DNA. This crucial step allowed them to identify the “instructions” necessary to create the spike protein, engineer corresponding synthetic mRNA and package that into their vaccines.
mRNA, as its moniker implies, is a messenger. This particular type of RNA is tasked with delivering messages to microscopic cellular machines called ribosomes, located in the cytoplasm of our cells, which are responsible for synthesizing proteins. Those ribosomes then interpret that message to make proteins and start executing its instructions, explained Phillip Sharp, a molecular biologist and MIT professor who shared the 1993 Nobel Prize in physiology or medicine for his contribution to our understanding of RNA.
Dendritic cells, the watchdogs of the immune system, play an essential role in responding to pathogens. They patrol the body in search of foreign invaders and, when they find one, start stimulating an immune response. When these cells encounter mRNA that’s been injected via vaccination, their ribosomes decode the message and allow the cells to temporarily display spike proteins identical to the ones found on the coronavirus’s exterior, Weissman said.
“Dendritic cells make the spike protein and then they present it to other immune cells and activate them to start the immune response,” he added.
The proteins allow the dendritic cells to alert two more key players in the immune system — T cells and B cells — that if they see those same spikes on any other cell, they should recognize them as a foreign invaders and either destroy them or generate antibodies to neutralize them immediately.
“There’s a memory component of those cell populations, and that stays in your body over a long period of time,” Sharp said. “If a similar virus infects you, those memory cells are ready to go. They are all perfected to go out and kill that virus.”
mRNA naturally degrades rapidly over time, so once it has served its purpose, it simply breaks down. The dendritic cells that expressed the spike protein eventually die and are replaced by new ones that continue to pick up that vaccine-delivered mRNA and repeat the process all over again in the course of about two weeks following immunization.
Some members of the public have expressed concern over unfounded speculation that these vaccines could negatively affect the body. But it is impossible for an mRNA vaccine to alter your DNA because synthetic mRNA operates only in the cytoplasm and is incapable of entering any other parts of our cells, such as the nucleus.
Like virtually all vaccines, those that use mRNA can trigger temporary symptoms like a fever, fatigue and soreness at the injection site that dissipate within a few days. But clinical trials that took place before the vaccines were authorized, as well as those that have followed, all suggest that these vaccines are both safe and effective at preventing serious illness and death.
“It’s always, always much more risky to get the disease than it is to get the vaccine,” Duprex said.
How did we get here?
mRNA was first injected into the muscles of mice in 1990 with the intention to deliver therapeutic proteins. But that effort “didn’t go very far,” according to Weissman, in large part due to the strong inflammatory response it induced, which severely sickened the animals involved.
That’s because in both animals and humans, cells feature a number of different receptors that can recognize mRNA as a foreign substance that must be destroyed. Those receptors help these cells distinguish their fellow cells from invaders like viruses, bacteria or even tumor cells.
Both RNA and DNA are composed of four nucleotides. More than a decade after that first injection in mice, Weissman and Karikó, who now serves as senior vice president at BioNTech, which partnered with Pfizer to manufacture their joint vaccine, figured out a way to insert an modified nucleotide that allows the synthetic mRNA to masquerade as a normal cell and circumvent those receptors, no longer triggering extreme inflammation. It also made the mRNA-spurred protein production more efficient.
“Our big discovery was that we could modify the RNA to make it non-inflammatory. And that had a couple of important features to it, but the first was that it greatly increased the amount of protein made off of the RNA,” which increased potency, Weissman said.
With the inflammation problem solved, Weissman and Karikó then turned to tweaking how mRNA is delivered so it could actually do its job once injected into the body. mRNA is an inherently “labile,” or unstable, material that can degrade rapidly to the point of being rendered ineffective.
After testing around 40 different types of delivery systems, the researchers found their golden ticket: lipid nanoparticles. These “droplets of fat” coat the mRNA and allow it to successfully enter our cells, which are also encapsulated in an oily substance.
Traditional vaccines are typically formulated with adjuvants that are designed to stimulate the immune response in their recipients. In what Weissman described as a lucky development, lipid nanoparticles happened to act as an adjuvant that stimulated a specific type of “helper cell” that promotes antibody responses.
“We use the lipid nanoparticles to get over a lot of the fragility [problems] because that protected the [mRNA] after you injected it into people, and it promoted these cells to take up the [mRNA] and start the vaccine process,” Weissman said.
Where mRNA stands today
In the years since Weissman and Karikó made these breakthroughs, mRNA research has continued to march on. Weissman and his current colleagues have worked on a variety of mRNA vaccines, including a “universal” flu shot that could cover a majority of influenza viruses and has so far proven to be effective in animal trials.
Compared to traditional vaccine platforms that require a series of complex steps, like growing mammalian cells in massive quantities and a viral purification process that looks different depending on the pathogen you’re working with, mRNA is now easy to manufacture at a fairly large scale.
Instead of needing “to reinvent the wheel every time you make a new vaccine,” Weissman said, “with [mRNA,] it’s the same reaction, and the only thing you have to do is plug in the new sequence for any virus, so that makes it very easy to produce a new vaccine.”
Both Moderna and Pfizer’s vaccines generated above 90 percent protection after two doses during clinical trials that played out before new variants of the virus marginally reduced their efficacy. Even so, the two give recipients remarkably high levels of protection, particularly against severe disease and death.
The CDC recently released new research that found these vaccines reduce a fully vaccinated person’s chance of getting infected with the coronavirus by 90 percent in “real-world” settings like the workplace.
Given that no vaccines have ever been approved to immunize people against any kind of coronavirus, and that the FDA’s original hope was to secure one with at least 50 percent efficacy to curb the pandemic, these results represent yet another significant milestone in annals of RNA technology.
Much more research lies ahead for these vaccines, both of which have been rolled out in the United States and in some other countries over the past few months. In addition to continuing to track safety and efficacy data, researchers need to know how well these vaccines prevent recipients from transmitting COVID-19 and how long the protection they offer lasts. Until we know the answers to those questions, recipients should keep following pandemic precautions like wearing a mask, even after they’ve gotten their two doses, experts say.
Johnson & Johnson’s vaccine, a one dose shot that uses a different yet similarly innovative platform to deliver immunity compared to mRNA, has also been authorized for use in the United States. Its strong efficacy and ability to be stored at a less strict temperature range makes experts hopeful that the rollout of this vaccine will help close some gaps in vaccine access both in this country and abroad.
In tackling COVID-19, Pfizer and Moderna’s vaccines have “paved the way,” Duprex said, when it comes to illustrating the utility of synthetic mRNA. And yet, while he anticipates that researchers will “only get better” at making tweaks that allow for better delivery and stability of this technology, he notes that we’re still in the early days of harnessing its utility — we also can’t assume that mRNA is “the next big panacea” that will solve all of our problems.
But, Duprex said, “the beautiful thing about this is this just gives us another brush for the palette of novel therapeutics [and] novel ideas that somebody in the next generation of scientists are going to be able to [use to] paint.”
So from the article, now these maniacs intend to make ALL future vaccines mRNA types.
No thanks.
I can’t read this I’m not a biologist.
It may very well be a modern day miracle.
Trump deserves the credit for getting them out this fast.
But it likely isn’t a one size fits all solution and may come with severe pitfalls should we continue treating it as such. Everyone’s needs are different. I am praying for the many who are still undecided about it.
Indeed but at what cost to the rest of a person’s health? Especially a young person? The immune system may be over activated and there may be side effects that are counter productive.
The jury is still out on long term effects...even if it’s impacting a few, and not ALL vaccinated people — some things are concerning. Like the vastly disrupted menstrual cycles many women (who normally have regular cycles) are experiencing.
So yes preventing COVID is something important — esp elderly and those most vulnerable — but there are other other things that we need to care about too and not sacrifice all at the altar of a single virus.
I’m worried that this approach to treating the virus is a sort of Maginot Line. It efficiently targets the spike protein — and what else? It seems very limited and rigid. I’m not hearing about any studies of people who recover from the virus naturally with their own immune systems.
I don’t know anyone who hasn’t had terrible side effects from these shots. That a pass for me
And everyone needs to remember, side effects are potentially not only in the week or two after. The side effect may be when you are triggered into a cytokine storm by another coronavirus 3 years from now. Or maybe you develop a cancer 12 years out and nobody will associate it. Or maybe you get Lupus or other inflammatory diseases 8 years from now.
This slap-dash rush job, with fraudulent emergency use authorization (Fraudulent, because not allowed if a therapy exists. So HCQ, Invermectin, etc were suppressed) under massive political pressure, and under massive biotech industry desperation to market their first product is not how we roll out viruses for such a 99.7% survival disease.
There is a growing body of knowledge these injections are immuno-contraceptives making young females PERMANENTLY unable to become pregnant and/or carry a baby to term. There is also evidence these dangerous side effects are able to be transmitted to those NOT injected via skin contact.
Family members NOT injected are developing blood clots through apparent contact transmission of the side effects through secretions of those injected.
In fact, in one published study of rats, a similar kind of experiment proved such secreted transmissions intentionally made ALL females in the study unable to reproduce without having to inject ALL of them.
This was intentional DEPOPULATION via transmitted infertility throughout the entire population.
Posted on 5/22/2021, 2:26:11 AM by ransomnote
Amazing results from nutrients and vitamins
ALTERNATIVE WAYS TO KEEP YOUR RESISTANCE UP & FIGHT COVID -19.
THIS REGIME WILL “NOT” PREVENT YOU FROM CATCHING THIS CRAZY VIRUS BUT IF YOU DO, IT WILL HELP TO SHAKE IT OFF FAIRLY QUICK. NOT ONLY THAT, BUT WILL BENEFITS YOUR HEALTH AS WELL, IF YOU CATCH THIS VIRUS OR NOT. EITHER WAY YOU WIN. ALONG WITH IT YOU WILL HAVE AQUIRED NATURAL IMMUNITY WITOUT ANY SHORT OR LONG TERM ADVERSE SIDE EFFECTS.
There are other ways and means to enhance your resistance against viruses including that by now infamous covid-19 virus aside from taking any of these “Quick” developed vaccines utilizing a messenger RNA. So far science has not evolved far enough yet to be certain how the human body will react many month or years down the road once we start tinkering around with our RNA and how our bodies will react should we encounter mutated strains of similar viruses.
Below is a list of vitamins as well as nutrients suggested by a physician to enhance your resistance, they are harmless and even beneficial to your body unless someone goes crazy and over doing it. Even so they will NOT protect you from getting any specific viruses; neither will any of those new “QUICK” developed vaccines. But not only will they make you more resistant but also help you to overcome the effects of such a virus more quickly, should you have bad luck getting it. And once you are over it, your natural immune system will take over and protect you considerably better than any vaccination, this according to a statement by Merck. The CATCH is to have these vitamins/nutrients in your system BEFORE you think you have caught this virus, as time is of essence so your system starts fighting the virus BEFORE it gets a chance to do any damage.
A suggestion to the wise, take some time and read up on each of these suggested components which is freely available on the internet.
Vitamin D — Vitamin D supplements are readily available and one of the least expensive supplements on the market. All things considered, vitamin D optimization is likely the easiest and most beneficial strategy that anyone can do to minimize their risk of COVID-19 and other infections, and can strengthen your immune system in a matter of a few weeks.
N-acetylcysteine (NAC) — NAC is a precursor to reduced glutathione, which appears to play a crucial role in COVID-19. According to one literature analysis,7 glutathione deficiency may actually be associated with COVID-19 severity, leading the author to conclude that NAC may be useful both for its prevention and treatment. For best results should always be taken with two to three times the amount of vitamin C.
Zinc — Zinc plays a very important role in your immune system’s ability to ward off viral infections.
Like vitamin D, zinc helps regulate your immune function8 — and a combination of zinc with a zinc ionophore, like hydroxychloroquine or quercetin, was in 2010 shown to inhibit SARS coronavirus in vitro. In cell culture, it also blocked viral replication within minutes.9 Importantly, zinc deficiency has been shown to impair immune function.
Melatonin — Boosts immune function in a variety of ways and helps quell inflammation. Melatonin may also prevent SARS-CoV-2 infection by recharging glutathione11 and enhancing vitamin D synthesis, among other things.
Vitamin C — A number of studies have shown vitamin C can be very helpful in the treatment of viral illnesses, sepsis and ARDS,12 all of which are applicable to COVID-19. Its basic properties include anti-inflammatory, immunomodulatory, antioxidant, antithrombotic and antiviral activities. At high doses, it actually acts as an antiviral drug, actively inactivating viruses. Vitamin C also works synergistically with quercetin.
Quercetin — A powerful immune booster and broad-spectrum antiviral, quercetin was initially found to provide broad-spectrum protection against SARS coronavirus in the aftermath of the 2003 SARS epidemic,14,15,16 and evidence suggests it may be useful for the prevention and treatment of SARS-CoV-2 as well. Not only that but quercetin also acts as an ionophore for zinc similar to hydroxychloroquine, in a matter of speaking it will unlock the cells to let the zinc in where it can attack the virus . It is also a good pain killer and better for the human body than Aspirin, what helps to subdue arthritis pain. I is good for sinus infection, in other words if you happen to have a runny nose.
B vitamins — B vitamins can also influence several COVID-19-specific disease processes, including17 viral replication and invasion, cytokine storm induction, adaptive immunity and hypercoagulability.
SUGGESTED DOSAGE
All components as suggested are individually obtained and freely available and if used with some common sense are not harmful and if anything beneficial to your health. However it is a good idea and highly recommended to read up on each component, as there is plenty of information available on the internet. You may be surprised to find out and learn about the many benefits they provide to your health.
Here is a suggested approximate dosage for each.
Vitamin D 1500 IU
Malatonine 3mg to 6mg suggested about one hour before you go to sleep.
QUERCETIN 500 mg to 1000 mg
NAC 500 mg to 1000 mg
Zinc 50 mg
Vitamin C 1500 mg or MORE !! but always should be to two three times as much as NAC
NAC 500 mg to 1000 mg
Vitamin B complex
So far whoever has been taking this regime of supplements and may have had a brush with this virus, shook it off fairly easily and quickly and the most important thing was that in the process such a person also acquired natural immunity. Not only that but at the same time this regime also helps to ease the effects of the regular flu.
Some of user’s comments:
Latest J&J Vaccine Info: Alex Berenson
4/15/2021, 10:49:29 AM • 27 of 28
Chauncey Gardiner to saintgermaine
Good post.
I have been on that same vitamin regimen since April 2020 along with approx 25 friends/family members. All of us socially active...restaurants, church, weddings, travel, etc. In other words, we’ve not changed our lives the past year. Not a one of us has tested positive and not a one has even had a cold. I’ve added hydroxychloroquine 200mg each Sunday starting about 6 mos ago.
Mississippi man partially paralyzed, unable to talk after J&J vaccine
4/16/2021, 6:48:45 PM • 37 of 39
upchuck to saintgermaine
Excellent regimen. Pretty much what I’ve been doing. I have been taking 5000 iu of Vit D3 per day for years and have never been sick (thank you Lord). With the China Virus, I upped it to 10,000 iu. I think zinc and quercetin are the most important.
10,570 DEAD 405,259 Injuries: European Database of Adverse Drug Reactions for COVID-19 “Vaccines”
5/21/2021, 7:41:23 AM • 52 of 52
jimjohn to saintgermaine
Been on similar regimens since August of 2020. Attended parties public events even a professional football game. Oh, and I fall in the high-risk category.
Also posted recently about hearing friends and associates who’ve taken the jab complain about the after effects.
Also note that my position would not recommend that I take this experimental vaccine.
Though these vaccines — developed by Pfizer and Moderna, respectively — are the first of their kind to be used on humans, this historic moment would not be possible without the decades of dead animals that came before it.
(Study intervention = 'vaccine') Sure sounds like the 'vaccine' itself is contagious via inhalation or skin contact. https://media.tghn.org/medialibrary/2020/11/C4591001_Clinical_Protocol_Nov2020_Pfizer_BioNTech.pdf
My brother is normally very intelligent and not an easy mark. But I cannot convince him of many plain facts; such that this is not a vaccine, that it is not officially listed as tested and that the death rates of Covid are only 6% of what they said. He took it right away and convinced others in the family to.
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