Posted on 05/04/2021 2:18:13 PM PDT by ransomnote
German scientists have found the exact 2 step process how the AstraZeneca COVID-19 vaccine causes blood clots in recipients. They describe a series of events that has to happen in the body before the vaccines create these large clots.
Scientists in Germany say they’ve worked out the two-step mechanism by which the AstraZeneca vaccine causes rare but devastating blood clots that gobble up the body’s supply of platelets.
“This is, in my opinion, rock-solid evidence,” said Andreas Greinacher, MD, head of the Institute of Immunology and Transfusion Medicine, University Hospital Greifswald, Germany, who was among the first scientists in the world to link the rare clots to antibodies against a key protein in platelets.
“This is what scientists usually think is confirmatory evidence,” he said in a call with reporters hours after publishing his study (read below) as a preprint ahead of peer review on the Research Square server.
Greinacher said that he believes the mechanism linking the vaccine with the rare clotting reactions is likely to apply to other vaccines that also use adenoviruses to ferry instructions for making the virus’s spike protein into cells.
In his new study, Greinacher and colleagues describe a series of events that has to happen in the body before the vaccines create these large clots.
He explained that while everyone has the basic immune machinery that leads to the unusual clots, it is almost always kept in balance. The body uses a series of checks to prevent any step in the process from getting out of control.
In the first step, the adenovirus shell in the vaccine, along with proteins from the cells where the vaccine is grown, come into contact with platelets from the blood.
Platelets are best known as colorless cell fragments that rush to the site of an infection or injury, helping the blood congeal to stop bleeding; they also play a key role in the body’s immune response.
When activated, they surround invaders like bacteria and change shape to release chemical signals they store in granules.
When platelets are activated en masse, as can happen rarely after a person takes the blood thinner heparin or gets the AstraZenecaAstraZeneca vaccine, they release a flood of these signals, Greinacher explained.
These blaring signals recruit an ancient and hard-to-control branch of the immune response.
“Imagine this is like a dragon in the cave who was sleeping for a long time [but] which now got alerted by someone’s throwing a stone on it,” he said.
The chemical signals awaken B-cells that then produce massive amounts of antibodies against the platelet factor 4 protein, which helps coordinate blood clotting.
The body erroneously thinks it is reacting to massive amounts of pathogens in the body, so the immune system overshoots.
The antibodies bind the platelets, the platelets recruit white blood cells, and “then the whole thing is exploding,” he said.
The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine.
EDTA opens junctions between cells that form the walls of blood vessels, causing them to become leaky. This allows the giant complexes formed by proteins and platelets to enter the blood circulation, where they — on very rare occasions — trigger that body-wide alarm.
Asked if he thought there was anything that could be done to make the vaccine safer, Greinacher said his first thought would be to try to get rid of the EDTA, which causes the second step in the process.
But he said he was not a vaccine developer and didn’t know how important it might be to its formulation.
Meanwhile, a new biased study falsely accuses GreatGameIndia of spreading misinformation for tweeting on the AstraZeneca controversy. The study found that the spread of our tweets after the controversy began increased significantly.
The only thing that the study looked into was an increase in the number of retweets in a specified duration. The tweets analysed include those from the period before the blood clot reports, and after.
It is ridiculous and malicious to brand any news organization as spreading incorrect information based on an increased number of retweets in a specific duration.
On the contrary, why this very crucial information of public health and safety did not spread through traditional mainstream media the way it should like all other information does?
Why was this very important aspect of the study ignored by the researchers?
Meanwhile, the US CDC and FDA have lifted their recommended pause on use of Johnson & Johnson’s coronavirus vaccine with a condition that it will now include a safety label warning that its vaccine comes with blood clot risks.
All of these serums are FDA “Authorized for use” but not “Approved”.
I totally agree a huge problem with the vaccines and just one more reason why I will never get shot up with this crap.
dude stfu
Yup, you get blood clots 1/1,000,000 times. Of course the incidence of DVT on long plane rides is 4% - 6%
Postoperative patients 5.6/10,000
So we know that the J&J is safer by an exponential factor than an 8 hour plane ride or elective surgery.
Pretty good odds
Next question?
It is not gene therapy, this statement demonstrated a certain special lack of biological understanding.
This is description of “HIT.” Heparin induced thrombocytopenia. Heparin can do this in statistically significant percentages of patients. This does not mean heparin is bad nor the covid vaccine shot (it is not a vaccine) is bad. Both have risks.
What we really have is risk benefit analysis. The old such as I have more risk from covid than thrombocytopenia and clots. We should take the shot as should anyone with comorbities. The young should not take the shot but just catch the disease at little risk and thus we achieve herd immunity.
Protect those at risk and do not worry about the others.
Dr. Fauci is a liar of great lies on top of lies and falsehoods. He is responsible for many deaths. He denigrated proven therapy for this disease due to political forces. He should be prosecuted for manslaughter.
Pull your head out of your nether regions. Moderna themselves state that mRNA is a gene therapy as per the FDA. Currently, mRNA is considered a gene therapy product by the FDA.
This is description of “HIT.” Heparin induced thrombocytopenia. Heparin can do this in statistically significant percentages of patients. This does not mean heparin is bad nor the covid vaccine shot (it is not a vaccine) is bad. Both have risks.
What we really have is risk benefit analysis. The old such as I have more risk from covid than thrombocytopenia and clots. We should take the shot as should anyone with comorbities. The young should not take the shot but just catch the disease at little risk and thus we achieve herd immunity.
Protect those at risk and do not worry about the others.
Dr. Fauci is a liar of great lies on top of lies and falsehoods. He is responsible for many deaths. He denigrated proven therapy for this disease due to political forces. He should be prosecuted for manslaughter.
~~~~~~~~~~~~~~~~~
It's not just throbmocytopenia. It's strokes, heart attacks, cardiac events, anaphylaxis, paralysis - and more. And that's just in the first few months before ADE begins to surface.
A doctor vaccinated 900 patients and has been witnessing 'evolving neurological problems' they are having. They're not even thinking about reporting it - he sees them later and they'll say something like, "Yeah. My arm went back to the way it was before the vaccine..."
I don't consider it to be the gene therapy, the FDA does, and Moderna even recognizes that stance. So you claiming otherwise wouldn't seem to demonstrate a certain special lack in your ability to research a subject. Currently, mRNA is considered a gene therapy product by the FDA.
ZING!!!
Gotcha, doc.
Let's go ahead and stick to gas doctoring. I don't think vaccines are your thing.
Tsk, tsk. Is that any way for an EMT who is also an expert in immunology to behave?
54-90 times, not 50-600 times.
awesome
It’s a vaccine and you people are effing idiots.
Long term trials most likely would have listed “clotting problems” as a side-effect and the vaccine would have been approved. 16 cases in 8 million is rare. But this is a public trial we are having and so the general public has a vote. that and one of the political parties appears to enjoy the control that fomenting a panic affords them.
“Yup, you get blood clots 1/1,000,000 times. Of course the incidence of DVT on long plane rides is 4% - 6%”
Both of those made up statements are false. Blood clots are happening far more than one in a million and 5% of people do not get DVT on long plane rides. I am an aviation expert and know this to be a false statement on your part.
So we should all just listen to you when the FDA, who is supposed to be the authority, labels it a gene therapy? So is it a vaccine, is it a gene-therapy, or maybe even both. Regardless of what it actually is, I'm pretty sure the decision doesn't rest with you. So you can get bent out of shape all you want. I say let's have an honest discussion and have all the information in play.
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