Covid-19: Single dose of Pfizer or AstraZeneca vaccine produces strong antibody response in over 80s

BMJ ^ | April 15, 2021 | BMJ

[Cathi]

A small number of people (eight) had signs of previous natural covid-19 infection. Compared with those without previous infection, their antibody and T cell responses after the first vaccine dose were significantly higher (691-fold and fourfold, respectively). The study also found stronger T cell responses in people who had received the AstraZeneca vaccine, with 31% of this group producing detectable T cell responses compared with 12% of the Pfizer-BioNTech vaccine group.

The researchers said that the clinical importance of the difference in T cell response was not yet clear, but it could be important when dealing with variants of covid-19. Paul Moss, co-author, principal investigator of the UK Coronavirus Immunology Consortium, and haematology professor at the University of Birmingham, said, “[T cells] can help to recognise different viral variants, they are somewhat less susceptible to loss of immune recognition against viral variants than antibody responses.

“The difference between antibodies and T cells is that antibodies are seeing shapes, like a lock and a key, and therefore a single amino acid can make a big change in the structure, and that means a lot of antibodies can’t bind. Whereas T cells see little peptide fragments, the virus is stripped into fragments and therefore the T cell response is not so badly lost against single amino acid changes.”

[deweyfrank]

So, if T-Cell response is significantly higher in previously infected after one vaccine dose, how high is it in those with no vaccine? And how long does T-Cell memory last in the unvaccinated?

[FreeReign]

So, if T-Cell response is significantly higher in previously infected after one vaccine dose, how high is it in those with no vaccine? And how long does T-Cell memory last in the unvaccinated?

Those are questions Fauci, in a million years, will never want to answer.

[deweyfrank]

Yep, It is becoming quite obvious that none of them want to answer. It’s always just “here, take this jab, you’ll like it”.

[Teacher317]

Has ANYONE asked how much these companies are being paid for the doses? Then finding a per-dose cost? Then comparing that to what other nations are paying? Is none of this important to know?

[Paradox]

The Adenovirus based vaccines, it has been said, might provide a _broader_ immunity than the MRNA vaccines. This study seems to show some evidence of that, with the 31 vs 12% Tcell activation in the Adeno ones vs mrna. I lean towards the J&J vaccine in this case.

[Cathi]

I think the interesting data in this study are:

(1) Having been previously infected with covid provides antibodies and T cell response magnitudes higher than one dose of the vax provides.

(2) The Pfizer vax produced weak T cell response at least after one dose.

(3) And most interesting T cells can help to recognise different viral variants, they are somewhat less susceptible to loss of immune recognition against viral variants than antibody responses.

A single amino acid can make a big change in the structure, and that means a lot of antibodies can’t bind. Whereas T cells see little peptide fragments, the virus is stripped into fragments and therefore the T cell response is not so badly lost against single amino acid changes.”

[walkingdead]

If I recall correctly, most of these new vaccines created antibodies ect very well. As early as the 60’s they thought they had hit the jackpot. Then came challenging the vaccinated with the wild virus. This is the point in time that everything went wrong. Seems that tricking the immune system into creating antibodies is easy, but dealing with the wild virus is another story.

I have yet to see anything explaining how they overcame these problems, problems that existed as late as a 2012 trial that did not make it past the animal stage.

One would have thought, that the first thing they would need to prove, and show the world, was the science behind how they overcame these deficiencies.

[ETCM]

Has ANYONE asked how much these companies are being paid for the doses? Then finding a per-dose cost? Then comparing that to what other nations are paying? Is none of this important to know?

You have spammed this "question" repeatedly, and must know that this is public information. If you are really a teacher, no wonder our kids are not learning...