Biotin, mitochondria, and dementia: Research reveals a connection (Biotin reverses aspects of Alzheimer’s/dementia)

Proceedings of the National Academy of Sciences ^ | January 7, 2021 | John Hewitt / Kelly M. Lohr, Bess Frost, Clemens Scherzer, and Mel B.

[ConservativeMind]

Biotin is also known as vitamin H, named for the German words "Haar" and "Haut," which mean hair and skin. This was due to the fact that even slight deficiencies cause hair thinning, skin rash or brittle fingernails. New research, just published in PNAS, now shows that some forms of severe neurodegeneration, like the frontotemporal dementia seen in Alzheimer's and Parkinson's, can directly result from lack of sufficient biotin.

The authors discovered this by looking at fruit flies with dementia. Now, before anyone chuckles, fruit flies actually make a nice model of Alzheimer's or other diseases when they are given the right genes. Human versions of defective MAPT (tau) genes cause these flies to develop tauopathies that resemble those that occur in our own brains. To delve deeper into the neurotoxicity of tau, they looked at over 7,000 fly genes in a forward genetic screen before zeroing in on one significantly modified toxicity of the tauR406W mutant. This gene, Btnd, encodes the biotinidase enzyme that extracts biotin from food sources or recycles it from used enzymes.

Biotin comes to us in the form of biocytin, which is simply a biotin linked to a lysine. Btnd cleaves off the biotin from biocytin, or from its attachment to lysine in carboxylases. When Btnd was also crippled in the flies, their dementia got worse. Furthermore, their mitochondria also became deformed and elongated. The researchers were able to remedy all of these effects by simply giving supplementary biotin, suggesting that some humans with dementia could similarly benefit.

[ConservativeMind]

A study on flies discovers biotin directly rescues dysfunctional mitochondria (the energy producers) in our cells responsible for dementia and Alzheimer’s Disease, reversing tau accumulation in the brain.

[linMcHlp]

bttt

[dadfly]

bookmark

[amorphous]

Someone needs to inform President Biden!

[GOP Poet]

biotinmark ;D

[Beowulf9]

https://www.healthline.com/nutrition/biotin-rich-foods#1.-Egg-yolks-

[BunnySlippers]

Save

[The Fop]

Biotin and Bitcoin used together is a miracle cure for dementia

[Vendome]

Paging Dr Jill bidden...

[ProtectOurFreedom]

LOL...I read "Bitcoin, mitochondria, and dementia" and just KNEW this would be an interesting thread. Imagine my dismay!

[Organic Panic]

WHOA WHOA WHOA!!! Hold on here. What does Fauci the Magnificent Keeper of All Knowledge say???

[Magic Fingers]

bkmk

[CondoleezzaProtege]

Wow

[faucetman]

H

[alexander_busek]

A study on flies discovers biotin directly rescues dysfunctional mitochondria [...]

I've been on a strict regimen of high-in-biotin foodstuffs for about a year now.

No sign of dementia yet - but every once in a while, I get these crazy cravings for spoilt vegetables and rotten fruits.

Regards,

[Prince of Space]

Thank God I’ve been chewing hair, skin & nail gummies for a couple of years, lol.

[SuperLuminal]

Someone better rush a couple of gallons of this vitamin to Joepedo before Harris gets off her knees and finds out about it...

[null and void]

Someone needs to inform President Biotin!

There.

Fixed.

[KneelBeforeZod]

And they all laughed at my peanut butter and liver sandwiches

[melsec]

Is there a supplement one can take. Asking for ....oh I forget.