Ivermectin for COVID-19 in Peru: 14-fold reduction in nationwide excess deaths, p=.002 for effect by state, then 13-fold increase after ivermectin use restricted

On May 8, 2020, Peru’s Ministry of Health approved ivermectin (IVM), a drug of Nobel Prize-honored distinction, for inpatient and outpatient treatment of COVID-19. As IVM treatments proceeded in that nation of 33 million residents, excess deaths decreased 14-fold over four months through December 1, 2020, consistent with clinical benefits of IVM for COVID-19 found in several RCTs. But after IVM use was sharply restricted under a new president, excess deaths then increased 13-fold.

To evaluate possible IVM treatment effects suggested by these aggregate trends, excess deaths were analyzed by state for ages ≥ 60 in each of Peru’s 25 states. To identify potential confounding factors, Google mobility data, population densities, SARS-CoV-2 genetic variations and seropositivity rates were also examined.

The 25 states of Peru were grouped by extent of IVM distributions: maximal (mass IVM distributions through operation MOT, a broadside effort led by the army); medium (locally managed IVM distributions); and minimal (restrictive policies in one state, Lima). The mean reduction in excess deaths 30 days after peak deaths was 74% for the maximal IVM distribution group, 53% for the medium group and 25% for Lima. Reduction of excess deaths is correlated with extent of IVM distribution by state with a p value of 0.002 using the Kendall τb test, well below the confidence threshold of 0.05 for an established clinical effect.

Mass treatments with IVM, a drug safely used in 3.7 billion doses worldwide, most likely caused the 14-fold reductions in excess deaths in Peru, prior to their 13-fold increase under reversed IVM policy. This strongly suggests that IVM treatments can likewise effectively complement immunizations to help eradicate COVID-19. The indicated biological mechanism of IVM, competitive binding with SARS-CoV-2 spike protein, is likely non-epitope specific, possibly yielding full efficacy against emerging viral mutant strains.

SSRN

Here are some details of the Peruvian study:

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3794909

Date Written: March 1, 2021

ABSTRACT:

Introduction. On May 8, 2020, Peru’s Ministry of Health approved ivermectin (IVM), a drug of Nobel Prize-honored distinction, for inpatient and outpatient treatment of COVID-19. As IVM treatments proceeded in that nation of 33 million residents, excess deaths decreased 14-fold over four months through December 1, 2020, consistent with clinical benefits of IVM for COVID-19 found in several RCTs. But after IVM use was sharply restricted under a new president, excess deaths then increased 13-fold.

Methods. To evaluate possible IVM treatment effects suggested by these aggregate trends, excess deaths were analyzed by state for ages ≥ 60 in each of Peru’s 25 states. To identify potential confounding factors, Google mobility data, population densities, SARS-CoV-2 genetic variations and seropositivity rates were also examined.

Results. The 25 states of Peru were grouped by extent of IVM distributions: maximal (mass IVM distributions through operation MOT, a broadside effort led by the army); medium (locally managed IVM distributions); and minimal (restrictive policies in one state, Lima). The mean reduction in excess deaths 30 days after peak deaths was 74% for the maximal IVM distribution group, 53% for the medium group and 25% for Lima. Reduction of excess deaths is correlated with extent of IVM distribution by state with a p value of 0.002 using the Kendall τb test, well below the confidence threshold of 0.05 for an established clinical effect.

Conclusion. Mass treatments with IVM, a drug safely used in 3.7 billion doses worldwide, most likely caused the 14-fold reductions in excess deaths in Peru, prior to their 13-fold increase under reversed IVM policy. This strongly suggests that IVM treatments can likewise effectively complement immunizations to help eradicate COVID-19. The indicated biological mechanism of IVM, competitive binding with SARS-CoV-2 spike protein, is likely non-epitope specific, possibly yielding full efficacy against emerging viral mutant strains.
Note: Funding Statement: Juan J. Chamie was funded by the Front Line COVID-19 Critical Care Alliance.

Declaration of Interests: The authors declare no conflict of interest .

Keywords: ivermectin, COVID-19, SARS-CoV-2, spike protein, Peru

CITATION:

Chamie-Quintero, Juan and Hibberd, Jennifer and Scheim, David, Ivermectin for COVID-19 in Peru: 14-fold reduction in nationwide excess deaths, p=.002 for effect by state, then 13-fold increase after ivermectin use restricted (March 1, 2021). Available at SSRN: https://ssrn.com/abstract=3794909

Download the PDF file of the study here:

https://papers.ssrn.com/sol3/Delivery.cfm/SSRN_ID3794909_code4200291.pdf?abstractid=3794909&mirid=1

It is most interesting and horribly true that our Biden-Harris led government is intent on reducing the power and numbers of our currently generally white population. Their reactions to USA Senate/Hourse of Reps, etc., governmental rules and laws based on that Constitution mean nothing to them.

In order to promote and then maintain the authoritarian socialist/communist government they are designing, they must reduce the white population by a significant amount, the cities under their control must be protected and all others outside the zones must die. Period. The world by the UN and WHO will feed and house us, the outsiders, and provide us succor.

What better way to reduce a population than let a powerless population (no guns or other means of self protection) whither away by reducing numbers (Covid and its minions of stupidity) and governance capability while others determine the rules?

It is most interesting and horribly true that our Biden-Harris led government is intent on reducing the power and numbers of our currently generally white population. Their reactions to USA Senate/House of Reps, etc., governmental rules and laws based on that Constitution mean nothing to them.

In order to promote and then maintain the authoritarian socialist/communist government they are designing, they must reduce the white population by a significant amount...being forced to not have drugs that will save their lives (i.e. Ivermicton), the cities under their control must be protected and all others outside the zones must die. Period. The world by the UN and WHO will feed and house us, the outsiders, and provide us succor.

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