Monulparivir, the drug that "completely" stops the spread of coronavirus in 24 hours: This antiviral drug could prevent virus carriers from developing severe symptoms and transmitting the disease in a single day, according to studies.

The COVID-19 vaccine may spell the end of the pandemic, but while mass vaccination is not available it is vital to stop community transmission. The new antiviral drug MK-4482 / EIDD-2801 or Molnupiravir, has managed to suppress "completely" the transmission of the coronavirus in just 24 hours , according to studies by the Institute of Biomedical Sciences of Georgia State University.

"This is the first demonstration of an orally available drug that quickly blocks the transmission of SARS-CoV-2 , so it could be a game changer," the researchers explained in the work published in the journal Nature Microbiology .

The antiviral drug was developed at Emory University in Atlanta by the drug innovation company Drug Innovation Ventures at Emory (DRIVE), which was licensed by Ridgeback Biotherapeutics, which partnered with Merck & Co. Molnupiravir was originally designed to treat the flu and prevent the virus from making copies of itself, creating errors during viral RNA replication.

The experts detail that tests were carried out on ferrets and it was observed that they presented a reduction in the amount of viral particles. Then those ferrets were put with others that had not been treated. None of the ferrets in the second group became infected with COVID-19.

"We believe that ferrets are a relevant transmission model because they easily spread SARS-CoV-2, but for the most part they do not develop a serious disease, which is very similar to the spread of SARS-CoV-2 in young adults," he said. Dr. Robert Cox, a postdoctoral fellow in the Plemper group and co-lead author of the study.

“We observed early on that MK-4482 / EIDD-2801 has broad spectrum activity against respiratory RNA viruses and that oral treatment of infected animals with the drug reduces the amount of viral particles spread by several orders of magnitude, drastically reducing transmission. These properties made MK-4482 / EIDD / 2801 a powerful candidate for the pharmacological control of Covid-19 ”, the report adds.

If this ferret-based data is translated into humans, Covid-19 patients treated with the drug could become non-infectious within 24 hours of starting treatment.

The drug can be taken orally, and treatment can be started early for a triple potential benefit: inhibiting patients' progress to severe disease, shortening the infectious phase to alleviate the emotional and socioeconomic cost of prolonged patient isolation, and containing quickly local outbreaks.

Molnupiravir is currently in advanced phase II / III clinical trials. It is being tested in three different doses every 12 hours for five days in patients with SARS-CoV-2.

I am not clinging to HCQ and Azithromycin. I am clinging to the 3 part concept—Ionophore, in-cell Virus Killer, lung protection. Ivermectin may be a better ionophore than HCQ and probably safer for a few with certain heart issues. Doxycycline may be a better for some patients than Azithromycin because of certain health issues. This is why all 4 drugs are prescription items so doctors can rule out the possible side effects. Are simvastatin and Pepcid ionophores, virus killers, or lung protectors? What is their mechanism of action? If they cannot get into infected cells where Covid is reproducing, how are they effective? If they are virus killers, do they need help getting into infected cells?

Zinc has specific problems getting into cells in large quantities which was the usefulness of HCQ. Apparently Ivermectin has similar utility but I have not seen scientific articles explaining its mechanism of action. Apparently the Koreans tested a number of existing drugs and Kaletra and zinc were 2 virus stoppers that were chosen to use with HCQ. I welcome other possibilities, but have not had time to find the scientific back-up for some of them. So I tend to stick with the ones I have already examined in detail. I welcome new information and scientific links for specific items. I think that for early treatment increases in nutrients like Vitamin C nd D3 may be enough lung protection. Dr. Zelenko has added Quercetin as an over-the-counter substitute for HCQ. You can see his series of links and modifications, and doses below, as well as much information on the fight against efforts to suppress low cost early treatment, and censorship of same.

https://faculty.utrgv.edu/eleftherios.gkioulekas/zelenko/index.html

gleeaikin :" I don’t know if this was censorship or if they felt the headline did not match the data."

You checked it through giggle ?
They are notorious for censoring anything that doesn't agree with their political bias.
Any search through giggle is censored ; giggle, on any issue involving covid on Giggle has less reliability than on "The Onion".

gleeaikin :" However, I would not have used the word “completely” stopped the virus without saying in ONE experiment using FERRETS."

Maybe so.
At least the experiment is 'promising'.
Yes, testing at this time is limited to ferrets.
Next stage is to see what inter-reaction with human blood, and then later, potentially to human patients.

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