From same source as referenced above:
” Mice injected with the neutralizing antibodies, but not isotype control, were 100% protected from death during TNF-α and IFN-γ shock (Figure 7A), indicating that these antibodies efficiently neutralized TNF-α and IFN-γ in vivo. “
Continuing:
” Next we investigated the therapeutic potential of these neutralizing antibodies in a murine sepsis model. Injection of a lethal dose of LPS induced mortality in 90% of mice by 48 h. Neutralization of TNF-α alone or IFN-γ alone provided some protection, but combined neutralization of TNF-α and IFN-γ provided 94% protection against LPS-induced lethality (Figure 7D). These in vivo models suggest that TNF-α and IFN-γ–mediated inflammatory cell death, PANoptosis, drives pathology in not only COVID-19, but also other diseases and syndromes associated with cytokine storm, including cytokine shock, sepsis, and HLH. “