I grew up 20 miles North of Plymouth and the family/families go back to since the Mayflower or shortly after. My sister did our genealogy. I helped a little and traced the paternal/surname back to 1630 to what would become Boston. We have 12 lines via multiple marriages into the Pilgrim lines going back to the Mayflower.
There are many millions of mayflower descendants.
One of the genealogy sites say over 35 millon people.