Posted on 07/20/2020 8:04:17 AM PDT by SeekAndFind
A vaccine being developed by AstraZeneca and the U.K.’s Oxford University appears to be safe, early-stage clinical trials have shown, marking a promising breakthrough in the race to develop a coronavirus vaccine, although it is yet to be seen whether it protects people against the virus.
KEY FACTS
* Trials of the vaccine involving some 1,077 healthy adult volunteers between April and May, showed the injection triggered the creation of antibodies and white blood cells to fight coronavirus.
* The study published in medical journal The Lancet, shows the vaccine also didn’t have any serious or dangerous side effects, although headaches and fever experienced by participants were treated with paracetamol.
* However, the vaccine, called AZD1222, requires larger trials to test whether it can offer protection against coronavirus.
* Britain has already secured a supply of 100 million doses of the vaccine, which is being developed at an unprecedented speed.
* Phase 2 and 3 trials for the Oxford project kicked off last May.
ADDITIONAL INFO
The vaccine is made from a genetically engineered virus and has been modified, meaning it looks like coronavirus, but cannot trigger the infection in people. Instead, it trains the immune system to attack the virus.
CRUCIAL QUOTE
Oxford’s Andrew Pollard, who is lead author on the study, said: “We hope this means the immune system will remember the virus, so that our vaccine will protect people for an extended period.”
He added: “However, we need more research before we can confirm the vaccine effectively protects against SARS-CoV-2 (COVID-19) infection, and for how long any protection lasts.”
(Excerpt) Read more at forbes.com ...
let’s see.
a dual use Virus Atrocity is released
where the patent application also includes
a vaccine if/when it is released.
dual use <=== kill by SARS and kill by Vaccine
oh, this will make Gates very happy,
and make WHO happy happy,
and make Soros and PeloXi an Xi very happy happy.
THIS IS AN ATROCITY
RE: dual use <=== kill by SARS and kill by Vaccine
By Dual Use, I think they mean these...
1. The vaccine produces Covid-19 antibodies and
2. The vaccine also produces virus-killing T cells.
Are you saying that the article’s report that the vaccine appears to be safe is false?
that is not what it means.
dual use <=== patent application for novel virus
and vaccine needed to help after the atrocity
of its release.
dual use is an ATROCITY against the human race.
I think what diogenesis is saying is that the creation of a patent for the virus (create the problem), and then creation of a vaccine for it (provide the solution), is an evil dual use/dual ploy.
And in the meantime, many tens of thousands of people died worldwide...
I want a date when, if this vaccine passes all tests, we can all be vaccinated.
After the election.
They’re manufacturing the vaccine in parallel with phase 3 trials. President Trump has pushed for them to do so and it’s happening. All the red tape is out of the way. All the normal bureaucracy is out of the way. They put the vaccine candidates through the exact same phase 1, phase 2, and phase 3 trials as every other vaccine candidate goes through and they only get approvals when they prove they’re safe and effective.
When President Trump signs off on them, they’re good to go. And it sounds like the trials could wrap up in October. Best October surprise every! Who do you want to vote for? President Trump, the hero who ended the COVID-19 mess? Or Joe Biden, who doesn’t know where he is or what he’s doing half the time?
We don't even know where he is, and the media could care less.
I know there are many on this board who have bought into the idea that vaccines are bad and, while I completely disagree with their opinions, I respect their opinions and decision not to take the vaccine.
Having said all that, I am really happy that at least one vaccine seems to be making headway, including going through the proper scientific protocols, and I am looking forward to taking it.
This news along with the report I saw today on FR showing many of us already have T cells to fight of Covid-19 gives me something positive to look forward too.
Well, Oxford’s vaccine is leading the pack (in the western world) in the race to be the first to develop an effective vaccine. It’s already in phase three of trials; the leading U.S. competitor, Moderna’s mRNA vaccine, is entering phase three now.
If Oxford were to stumble, the wait for a vaccine would get longer. According to today’s preliminary results in the The Lancet, they have not stumbled.
Also, Two: Scientists are increasingly focused on the fact that T-cells, not just antibodies, may be key in putting out the fire when someone’s infected with coronavirus. T-cells target and destroy cells in the body that are infected. “Evaluating an immune response without accounting for T cells is like inventorying a national air force but leaving out the bomber jets,” writes Derek Thompson this morning in the Atlantic.
In fact, some evidence points to the possibility that T-cells provide more robust and more durable immunity to COVID-19 than antibodies, with one French study having uncovered cases of people recovering from the disease without any antibodies at all. Needless to say, a vaccine that boosts antibodies and T-cells is a choice vaccine.
The Oxford vaccine boosts both, per the early data published today from phase one/two trials. “We’re getting both sides of the immune system stimulated and that is fairly unusual for vaccines,” said the director of the Oxford project to NBC. Their product works by teaching the body to recognize the “spike protein” that SARS-CoV-2 uses to bind to cells and to neutralize it more efficiently. Then, if/when you’re infected with the virus itself, antibodies and T-cells are ready to pounce and squash it before it has time to replicate.
MORE ENCOURAGING NEWS:
Oxford isn’t the only vaccine-maker to show a “dual immunity” response from its product: “In a paper also released Monday, [German firm] BioNTech and Pfizer said their vaccine also induced T-cell responses.” As far as I’m aware, every vaccine that’s made it through phase one trials thus far has induced mild side effects in recipients, although nothing serious. Oxford’s vaccine is no exception, generating “fever, headaches, muscle aches, and injection site reactions, in about 60% of patients.”
The Oxford shot elicited neutralizing antibodies after a single dose. That may be an important advantage in quickly raising immunity.
I don’t read that clearly in the Moderna data, I think they need two doses to see plausibly protective neutralizing antibodies.
As I say, they’re in phase three trials now. That’s the acid test, when they inject people with the vaccine and send them out into the population to see if anyone gets infected. It’s one thing to produce antibodies and T-cells, it’s another to actually prevent infection by SARS-CoV-2. If all goes well, some doses of the vaccine could be available in limited situations by September. Oxford and its partner, AstraZeneca, are still aiming to make the vaccine widely available by the end of 2020 although that remains an absolute best-case scenario.
What do we do until then? We cross our fingers and hope for effective stopgap treatments that make the disease less deadly in severe cases than it is now. Like … this:
The treatment from [British]-based biotech Synairgen uses a protein called interferon beta which the body produces when it gets a viral infection.
The protein is inhaled directly into the lungs of patients with coronavirus, using a nebuliser, in the hope that it will stimulate an immune response.
The initial findings suggest the treatment cut the odds of a Covid-19 patient in hospital developing severe disease – such as requiring ventilation – by 79%.
Patients were two to three times more likely to recover to the point where everyday activities were not compromised by their illness, Synairgen claims.
All wonderful news! With the combination of improved treatments and a safe and effective vaccine on the horizon, I’m more hopeful than ever we’ll be through this soon.
And I can’t wait to see the first round of polling after President Trump stands up and tells the world we have a working vaccine ready to go. NOBODY thought we’d have a vaccine in less than a year. Some people thought we’d never have one. Oxford may be ahead of Moderna, but I think our real best case scenario is that all 5 of the leading candidates (as chosen by the Trump administration) make it through phase 3 trials and we have 5 different options - all manufactured in parallel - to choose from. That would mean having a massive quantity of safe and effective vaccines available quickly, rather than relying on one company to mass produce enough for the whole world.
RE: I think our real best case scenario is that all 5 of the leading candidates (as chosen by the Trump administration) make it through phase 3 trials and we have 5 different options - all manufactured in parallel - to choose from.
COMPETITION IS GOOD! THE MORE, THE BETTER.
1. It encourages the competing companies to make sure that they produce a safe, effective product (vaccine) so that they will profit ( I know, the AOC’s and Bernie Sanders of this world hate the word, but who cares ).
2. Competition DRIVES PRICES DOWN.
3. It discourages monopolies.
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