Posted on 06/17/2020 12:03:38 AM PDT by Grandpa Drudge
Seems that the Chinese labs were striving for human-to-human transmission of the bat sourced viruses. The Covid-19 virus looks to be the successful result.
Using the SARS-CoV infectious clone as a template (7), we designed and synthesized a full-length infectious clone of WIV1-CoV consisting of six plasmids that could be enzymatically cut, ligated together, and electroporated into cells to rescue replication competent progeny virions (Fig. S1A). In addition to the full-length clone, we also produced WIV1-CoV chimeric virus that replaced the SARS spike with the WIV1 spike within the mouse-adapted backbone (WIV1-MA15, Fig. S1B). WIV1-MA15 incorporates the original binding and entry capabilities of WIV1-CoV, but maintains the backbone changes to mouse-adapted SARS-CoV. Importantly, WIV1-MA15 does not incorporate the Y436H mutation in spike that is required for SARS-MA15 pathogenesis (8). Following electroporation into Vero cells, robust stock titers were recovered from both chimeric WIV1-MA15 and WIV1-CoV.
Your comment accurately highlights the origin of SARS-CoV, as described in this article. The specific point of this article is that they used SARS-CoV as well as WIV1-CoV (from Wuhan Institute of Virology) to produce the man made Chimera viruses.
Therefore, my assessment is that SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus
No. There’s not. That’s why I asked.
What my post presents is an article dated March 15, 2016 from the National Academy of Sciences that describes precisely HOW NIAID and Wuhan Institute of Virology accomplished creating a man made chimeric virus using SARS-CoV as well as WIV1-CoV as a base starting point.
I concluded from that article that SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus.
And I now defend and stand firmly behind that conclusion.
Thanks for the advice, I think I’ll just ignore it.
The specific point of this article is that NIAID and Wuhan Institute of Virology used SARS-CoV as well as WIV1-CoV (from Wuhan Institute of Virology) to produce man made Chimeric viruses, prior to March 15, 2016.
“Thanks for the advice, I think I’ll just ignore it.”
You say you’ll ignore the advice but the fake headline you posted is suddenly changed. Words don’t mean anything to you do they?
I’m addressing this:
“I concluded from that article that SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus.”
This article in no way provides evidence, pro or con, that the current Covid-19 virus is a chimera.
The SARS-CoV-2 virus sequence is completely known. It is not a chimera of WIV1 and any other viruses or any known Coronaviruses of this class.
What are you considering to be evidence that the SARS-CoV-2 is a chimera?
“Therefore, my assessment is that SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus”
And you are mistaken. No one in American virus research is making that claim. They would have spotted a WIV1-CoV connection to SARS-CoV-2 immediately. They all know about the WIV1-CoV research.
"SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus" was the opening line of my first post in this thread. At the time of this post, I expected that to be the thread headline, but was not aware of the requirement that the headline must come from the posted article. My first post also includes the "thread headline" ("SARS-like WIV1-CoV poised for human emergence") of the referenced article.
Since you seen determined to twist and suggest the intent and motives of my post are somehow "fake" I submit this reply for the edifice of other readers of this thread.
It looks the same now, because admins changed it from a false headline.
Note: the following four paragraphs are copied directly from the article this thread is based on, with bold italic emphasis added by me.
This manuscript describes efforts to extend surveillance beyond sequence analysis, constructing chimeric and full-length zoonotic coronaviruses to evaluate emergence potential.
Focusing on SARS-like virus sequences isolated from Chinese horseshoe bats, the results indicate a significant threat posed by WIV1-CoV. Both full-length and chimeric WIV1-CoV readily replicated efficiently in human airway cultures and in vivo, suggesting capability of direct transmission to humans.
Using the SARS-CoV infectious clone as a template (7), we designed and synthesized a full-length infectious clone of WIV1-CoV consisting of six plasmids that could be enzymatically cut, ligated together, and electroporated into cells to rescue replication competent progeny virions (Fig. S1A).
In addition to the full-length clone, we also produced WIV1-CoV chimeric virus that replaced the SARS spike with the WIV1 spike within the mouse-adapted backbone
Let me tell you what they mean to me:
Prior to March 15, 2016, according to this report, NIAID and Wuhan Institute of Virology constructed chimeric and full-length zoonotic coronaviruses
Using the SARS-CoV infectious clone as a template (7), THEY designed and synthesized a full-length infectious clone of WIV1-CoV consisting of six plasmids that could be enzymatically cut, ligated together, and electroporated into cells to rescue replication competent progeny virions (Fig. S1A).
In addition to the full-length clone, THEY also produced WIV1-CoV chimeric virus that replaced the SARS spike with the WIV1 spike within the mouse-adapted backbone
Note carefully, that I did NOT say they made the Covid-19 virus.
What I DID say was "Here is the blueprint for Modifying (man made) SARS-Cov based Virus"
What I am now saying is that they documented the methods they used and results achieved in creating a full-length efficiently human infectious clone of WIV1-CoV virus.
And now I say that what we currently know about SARS-CoV-2 (Covid-19) appears to many scientists to possibly be similar to what might have been accomplished by the above documented process, as published by NIAID in March, 2016.
And it's rather hard for me to believe that is just coincidental.
“Note carefully, that I did NOT say they made the Covid-19 virus.”
That is certainly what you did say.
I take your word for it that you didn’t mean to say it, or that’s not what you meant.
It’s truly hard to know what you do mean.
I’m a molecular biologist. Feel free to ask me questions. Keep them simple.
And you are mistaken. No one in American virus research is making that claim. They would have spotted a WIV1-CoV connection to SARS-CoV-2 immediately. They all know about the WIV1-CoV research."
My response:
As a well documented matter of fact "they" (NIH, NIAID) DID spot the unquestionable connection between SARS-CoV and SARS-CoV-2 immediately (in 2019, 2020).
And other "scientists" have made similar claims starting in March, 2020. Other "scientists" have "refuted" those claims, for whatever that is worth. It remains to be proven.
I do not claim to be a "scientist". Consider me to be a detective following the breadcrumbs to discover the truth in a powerfully complex and potentially politically charged mystery.
The TRUTH is yet to be discovered
Searching through this thread, here is a copy of words I did say:
SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus
Here is the blueprint for Modifying (man made) SARS-Cov based Virus
My assessment is that the PNAS article indicates strongly that NIH National Institute of Allergy and Infectious Disease, managed br Dr. Anthony Fauci, and the Wuhan Institute of Virology, managed by Dr. Zhengli-Li Shi cooperated to create what ultimately became the chimeric virus SARS-CoV-2 (Covid-19) pandemic.
Your comment accurately highlights the origin of SARS-CoV, as described in this article. The specific point of this article is that they used SARS-CoV as well as WIV1-CoV (from Wuhan Institute of Virology) to produce the man made Chimera viruses.
Therefore, my assessment is that SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus
So, one more time: I did NOT say they (NIAID) made the Covid-19 virus in this March 2016 project.
The closest I came to that was "My assessment is that the PNAS article indicates strongly that NIH National Institute of Allergy and Infectious Disease, managed br Dr. Anthony Fauci, and the Wuhan Institute of Virology, managed by Dr. Zhengli-Li Shi cooperated to create what ultimately became the chimeric virus SARS-CoV-2 (Covid-19) pandemic.
And I still say that and it should be clear enough today that that is what I mean to say.
I’m not putting words in your mouth. In 22 you wrote:
“Therefore, my assessment is that SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus “
That 2016 PNAS article provided no evidence this is the case nor does any sequence information on SARS-CoV-2 provide evidence it is a “man-made chimeric virus”.
What evidence do you think there is that it is “a man made chimeric virus”?
Suppressed Science Indicates Covid-19 Is Man Made
https://www.linkedin.com/pulse/suppressed-science-indicates-covid-19-man-made-jenna-luche-thayer/
And this PDF Check especially page 4 of the PDF
I'm hoping that Dr. Fauci's influence leaves room for serious consideration of these ideas.
The title also announces to Freepers what the authors of the linked article believed to be an accurate short summary of the article's contents. In this case, since the article was a product of the National Academy of Sciences, that title carried a lot of weight -- much more than if the title was just the opinion of some Freeper named "Grandpa Drudge."
The title you used, "SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus" is not the title of the linked article. It makes a claim that is not supported by the National Academy of Sciences, or even supported by the contents of the article. It is, therefore, a lie. This is obvious without even reading the article, since it was written in 2016, and COVID-19 was named in December, 2019.
That has nothing to do with whether or not COVID-19 was made in a Wuhan lab. For the record, I think it probably was.
Welcome to FR.
The title was corrected properly by FR admin to"SARS-like WIV1-CoV poised for human emergence" within hours of my opening the thread (and I thanked admin for the correction). I also point out that the "short summary" under the title is an accurate excerpt copied directly from the article, and not in need of any correction.
I accept criticism for my administrative error.
However, I maintain and defend my "assessment" that SARS-CoV-2 (Covid-19) appears to be a man made chimeric virus.
And one more time: I did NOT say Covid-19 was created in the actions in this report. I DID say this report was a "blueprint" for Modifying (man made) SARS-Cov based Virus.
The obvious question still open for challenge is whether this "blueprint" was followed by anyone (after March, 2016) to perfect SARS-CoV into SARS-Cov-2 before it appeared as Covid-19 in China. There remains significant suspicion that is the case.
Re: Title
Thanks for the update.
I’m surprised the mods did not yank the entire post.
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