Posted on 06/16/2020 12:33:05 PM PDT by ConservativeMind
There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may be useful in increasing the healthy period of life known as healthspan.
What is Fisetin?
Fisetin is a part of the flavonoid family of polyphenols. Fisetin acts as a pigment and influences the color of various fruits and vegetables.
Senescent cells and senolytics
As we grow older, we accumulate more and more damaged cells which cease dividing and enter a state known as senescence. Once they enter this state, they begin to secrete a cocktail of inflammatory signals known as cytokines, which summon the immune system to remove them.
When we are young, this system works perfectly, and the damaged cells are promptly removed; however, as we grow older, our immune systems slow down and senescent cell clearance begins to falter. Eventually, clearance slows down to the point that senescent cells begin to build up in the tissues contributing to the chronic inflammation known as inflammaging, harming nearby healthy cells and making them also senescent, preventing tissue repair, and facilitating the development of various age-related diseases.
It was proposed that finding ways to help the body clear away senescent cells may be the key to delaying or preventing various age-related diseases, and indeed in 2011, that idea was put to the test and seemed to bear fruit. Jan van Deursen and his team at Mayo Clinic engineered a mouse that was able to destroy its senescent cells when given a certain chemical.
Fisetin appears to be a senolytic
A number of plant flavonoids, such as quercetin, apigenin, luteolin, and curcumin, have been examined recently for their senolytic activity, and fisetin is the latest of these to enter the spotlight.
(Excerpt) Read more at lifespan.io ...
A Fisetin-Berberine-Rutin combo, when used during a fast can be very strong. It’s very potent and with exaggerated results, so truthfully it needs to be studied, lest it be too potent.
The anecdotal results are dramatic changes in blood chemistry, including slamming down blood sugar, cholesterol *below* normal, low blood pressure, low blood sodium, etc. Too much, too fast for a casual user, so experiments need to be conducted to insure safety.
It almost enters the realm of an “emergent” treatment, for someone with imminent, life threatening conditions, so once again, NOT for casual use.
the big question is as to whether the Fisetin-Berberine-Rutin combo promotes autophagy and increase ketones. do you know?
I’ve been fasting for a many years. If it’s between 11:00 PM and 6:30 AM then I’m not eating. It’s great
Thank you for the insight. I will look further into that.
An interesting thread of fisetin testers (in the comments below):
It would have to be used longer than it was, but the effects elsewhere were so great that it would be unwise to do so out of a controlled situation.
Foods rich in fisetin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/
“One such flavonoid, fisetin, is found in various fruits and vegetables, such as strawberry, apple, persimmon, grape, onion, and cucumber”
Make sure you have fresh fruits in your diet. Have an apple today. Put some cucumber in your salad.
https://www.allrecipes.com/recipe/237984/marinated-cucumber-onion-and-tomato-salad/
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