Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

Science Direct ^ | May 2020 | Richard Horowitz, Phyllis Freeman, James Bruzzese

[edwinland]

Purpose

Infection with COVID-19 potentially can result in severe outcomes and death from “cytokine storm syndrome”, resulting in novel coronavirus pneumonia (NCP) with severe dyspnea, acute respiratory distress syndrome (ARDS), fulminant myocarditis and multiorgan dysfunction with or without disseminated intravascular coagulation. No published treatment to date has been shown to adequately control the inflammation and respiratory symptoms associated with COVID-19, apart from oxygen therapy and assisted ventilation. We evaluated the effects of using high dose oral and/or IV glutathione in the treatment of 2 patients with dyspnea secondary to COVID-19 pneumonia.

Methods

Two patients living in New York City (NYC) with a history of Lyme and tick-borne co-infections experienced a cough and dyspnea and demonstrated radiological findings consistent with novel coronavirus pneumonia (NCP). A trial of 2 g of PO or IV glutathione was used in both patients and improved their dyspnea within 1 h of use. Repeated use of both 2000 mg of PO and IV glutathione was effective in further relieving respiratory symptoms.

Conclusion

Oral and IV glutathione, glutathione precursors (N-acetyl-cysteine) and alpha lipoic acid may represent a novel treatment approach for blocking NF-κB and addressing “cytokine storm syndrome” and respiratory distress in patients with COVID-19 pneumonia.

[absalom01]

Same. Low risk, maybe helps. What have you got to lose?

[gattaca]

bmp

[LucyT]

.

PING

[matthew fuller]

I’m taking 1000 mg in the AM and 600 mg PM.

[PA Engineer]

Thanks for the post and happy you are back.

The Russian study is very important. The ROS/GSH ratio is an interesting tool, especially for other areas of neurodegeneration. This is an important target to explore with say Parkinson's and Alzheimer's. Observationally these patients always have worsening of symptoms during viral infection. Many times the changes are permanent after discharge.

Glutathione and iron handling changes are consistent in these groups. In our special patients there has been a mystery as to why they are stable during long periods and then suddenly deteriorate and do not return to baseline. Viral infection and peroxidation is a logical hypothesis to explore.

P.S. Doing better myself. It is going to be a long drawn out process, but with expected good outcomes.

[bitt]

p

[Freedom56v2]

Any danger in taking too much?

[Faith65]

bkmk

[Carriage Hill]

BKMK.