[RummyChick]

Farid Jalali @farid__jalali My thoughts on #COVID19 Lung Injury, centered around 1) ACUTE thrombotic vascular injury phase due to unopposed ACE, followed by 2) SUBACUTE remodeling due to unopposed ACE2 with progressive DILATATION of pulm capillaries, accounting for prone benefit via perfusion improvement.

[RummyChick]

Farid Jalali
@farid__jalali
·
34m
@cameronks

@srrezaie
I should clarify ACE expression is reduced in LUNG biopsy tissue of chronic asthmatic “human” subjects. Reduces the injurious initial unopposed surge of Ang II. https://jacionline.org/article/S0091-6749(99)70385-4/pdf